Basic Clinical Radiobiology (eBook, PDF)

Redaktion: Joiner, Michael C.; Kogel, Albert J. van der

• Format: PDF

Produktbeschreibung

This textbook sets out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics, and radiation technology.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 360
• Erscheinungstermin: 28. August 2018
• Englisch
• ISBN-13: 9780429955402
• Artikelnr.: 55276296

Inhaltsangabe

Introduction: The significance of radiobiology and radiotherapy for cancer
treatment. Irradiation-induced damage and the DNA damage response. Cell
death after irradiation: How, when and why cells die. Quantifying cell kill
and cell survival. Radiation dose-response relationships. Linear energy
transfer and relative biological effectiveness. Physics of radiation
therapy for the radiobiologist. Tumour growth and response to radiation.
Fractionation: The linear-quadratic approach. The linear-quadratic approach
in clinical practice. Modified fractionation. Time factors in normal tissue
responses to irradiation. The dose-rate effect. Pathogenesis of normal
tissue side effects. Stem cells in radiotherapy. Normal tissue tolerance
and the effect of dose inhomogeneities. The oxygen effect and therapeutic
approaches to tumour hypoxia. The tumour microenvironment and cellular
hypoxia responses. Combined radiotherapy and chemotherapy. Molecular
targeted agents for enhancing tumour response. Biological individualisation
of radiotherapy. Molecular image guided radiotherapy. Retreatment tolerance
of normal tissues. Biological response modification of normal tissue
reactions: Basic principles and pitfalls. Hadron therapy: The clinical
aspects. Tissue response models. Second cancers after radiotherapy.