Basic Clinical Radiobiology (eBook, PDF)

Redaktion: C. Joiner, Michael; KogeJ. l, Albert van der

• Format: PDF

Produktbeschreibung

The sixth edition of this internationally successful text includes the many positive advances in radiation oncology that have occurred over the past decade, and which continue to keep radiation at the cutting edge of cancer therapy.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 360
• Erscheinungstermin: 8. Januar 2025
• Englisch
• ISBN-13: 9781040194263
• Artikelnr.: 72301033

Autorenporträt

Michael C. Joiner, PhD, is a founding teacher and previous Course Director of the Basic Clinical Radiobiology Course at ESTRO, and Advisor and Teacher of Clinical Radiobiology at Wayne State University, Detroit, Michigan, USA. Albert J. van der Kogel, PhD, is a founding teacher and previous Course Director of the Basic Clinical Radiobiology Course at ESTRO, and Advisor and Teacher of Clinical Radiobiology at the University of Wisconsin, Madison, Wisconsin, USA.

Inhaltsangabe

Preface
About the editors
List of contributors
Glossary
1. Introduction: The significance of radiobiology and radiotherapy for
cancer treatment. 2. Irradiation-induced damage and the DNA damage
response. 3. Cell death after irradiation - how, when and why cells die.
4. Quantifying cell kill and cell survival. 5. Radiation dose-response
relationships. 6. Linear energy transfer and relative biological
effectiveness. 7. Physics of radiation therapy for the radiobiologist. 8.
Tumour growth and response to radiation. 9. Fractionation: The
Linear-Quadratic approach. 10. The linear-quadratic approach in clinical
practice. 11. Modified fractionation. 12. Early effects in epithelial
tissues, the role of stem cells and time factors. 13. The dose-rate effect.
14. Pathogenesis of late normal tissue effects. 15. Volume effects,
regional responses, and risk models. 16. Biological modifiers of normal
tissue effects. 17. The oxygen effect and therapeutic approaches to tumour
hypoxia. 18. The tumour microenvironment and cellular hypoxia responses.
19. Combined radiotherapy and chemotherapy from the perspective of the
Radiation Oncologist. 20. Molecular targeted agents for enhancing tumour
response. 21. Biological individualisation of radiotherapy. 22. Molecular
image guided radiotherapy. 23. Retreatment tolerance of normal tissues.
24. Cancer stem cells in radiotherapy. 25. Hadron therapy: The clinical
aspects. 26. Radiation and the immune system. 27. Second cancers after
radiotherapy.
Index