Bioactive Heterocyclic Compound Classes (eBook, PDF)
Agrochemicals
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Bioactive Heterocyclic Compound Classes (eBook, PDF)
Agrochemicals
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The chemistry of heterocycles is an important branch of organic chemistry. This is due to the fact that a large number of natural products, e. g. hormones, antibiotics, vitamins, etc. are composed of heterocyclic structures. Often, these compounds show beneficial properties and are therefore applied as pharmaceuticals to treat diseases or as insecticides, herbicides or fungicides in crop protection. This volume presents important agrochemicals. Each of the 21 chapters covers in a concise manner one class of heterocycles, clearly structured as follows: * Structural formulas of most important…mehr
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The chemistry of heterocycles is an important branch of organic chemistry. This is due to the fact that a large number of natural products, e. g. hormones, antibiotics, vitamins, etc. are composed of heterocyclic structures. Often, these compounds show beneficial properties and are therefore applied as pharmaceuticals to treat diseases or as insecticides, herbicides or fungicides in crop protection. This volume presents important agrochemicals. Each of the 21 chapters covers in a concise manner one class of heterocycles, clearly structured as follows: * Structural formulas of most important examples (market products) *Short background of history or discovery * Typical syntheses of important examples * Mode of action * Characteristic biological activity * Structure-activity relationship * Additional chemistry information (e.g. further transformations, alternative syntheses, metabolic pathways, etc.) * References A valuable one-stop reference source for researchers in academia and industry as well as for graduate students with career aspirations in the agrochemical chemistry.
Produktdetails
- Produktdetails
- Verlag: Wiley-VCH
- Seitenzahl: 302
- Erscheinungstermin: 9. August 2012
- Englisch
- ISBN-13: 9783527664443
- Artikelnr.: 37361913
- Verlag: Wiley-VCH
- Seitenzahl: 302
- Erscheinungstermin: 9. August 2012
- Englisch
- ISBN-13: 9783527664443
- Artikelnr.: 37361913
Clemens Lamberth is a senior team leader in the crop protection research department of Syngenta AG, Switzerland. He studied chemistry at the Technical University of Darmstadt, Germany, where he obtained his Ph.D. under the supervision of Prof. Bernd Giese in 1990. Subsequently, he spent one and a half years as a postdoctoral fellow in the group of Prof. Mark Bednarski at the University of California at Berkeley, U.S.A. In 1992 Clemens Lamberth joined the agrochemical research department of Sandoz Agro AG, Switzerland, which is today, after two mergers, part of Syngenta Crop Protection AG. Since 20 years he is specialized in fungicide discovery. He was the organizer of the two-day session 'New Trends for Agrochemicals' at the 2nd EUCHEMS congress in Torino 2008. He is the author of 46 publications and 56 patents and the inventor of Syngenta's fungicide mandipropamid (Revus®, Pergado®). Jürgen Dinges obtained his M.S. degree in organic chemistry at the Technical University in Darmstadt, Germany in 1988. He then joined the group of Prof. Frieder W. Lichtenthaler at the same University, where he received his Ph.D. degree in organic chemistry and chemical engineering in 1991. After being awarded a Feodor-Lynen scholarship from the Humboldt foundation, he spent 18 months as a postdoctoral fellow in the group of Prof. William G. Dauben at the University of California at Berkeley, U.S.A. In 1993, Jurgen Dinges joined the department for biochemistry at Syntex, U.S.A. and since 1995 he is working in the pharmaceutical research department at Abbott Laboratories, U.S.A. In 2009, he was a guest editor for Current Topics in Medicinal Chemistry for a special issue on Parkinson?s disease. He is an author of 17 publications and 23 patents and a co-inventor of more than 10 clinical drug development candidates.
IINTRODUCTION THE SIGNIFICANCE OF HETEROCYCLES FOR PHARMACEUTICALS AND AGROCHEMICALS Introduction Heterocycles as Framework of Biologically Active Compounds Fine-Tuning the Physicochemical Properties with Heterocycles Heterocycles as Prodrugs Heterocycles as Peptidomimetics Heterocycles as Isosteric Replacement of Functional Groups Heterocycles as Isosteric Replacement of Alicyclic Rings Heterocycles as Isosteric Replacement of other Heterocyclic Rings PART I: Herbicides TRIAZINE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationships PYRIMIDINYL AND TRIAZINYLSULFONYLUREA HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship ACETOHYDROXYACID SYNTHASE INHIBITING TRIAZOLOPYRIMIDINE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship HPPD-INHIBITING BENZOYLPYRAZOLE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PYRIDYLOXYPHENOXYPROPIONATE HERBICIDES: INHIBITORS OF ACETYL-COA CARBOXYLASE Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationships IMIDAZOLINONE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PROTOPORPHYRINOGEN-IX-OXIDASE-INHIBITING URACIL HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship Part II: Fungicides BENZIMIDAZOLE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship MORPHOLINE FUNGICIDES FOR THE TREATMENT OF POWDERY MILDEW Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship STEROL BIOSYNTHESIS INHIBITING TRIAZOLE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship METHIONINE BIOSYNTHESIS-INHIBITING ANILINOPYRIMIDINE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PHENYLPYRROLE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship BROAD-SPECTRUM FUNGICIDALLY ACTIVE PYRIMIDINYLDIOXY STROBILURINS INHIBITING THE RESPIRATORY CHAIN Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PYRAZOLE CARBOXAMIDE FUNGICIDES INHIBITING SUCCINATE DEHYDROGENASE Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationships Part III: Insecticides AVERMECTIN INSECTICIDES AND ACARICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PYRIDINE AND THIAZOLE-CONTAINING INSECTICIDES AS POTENT AGONISTS ON INSECT NICOTINIC ACETYLCHOLINE RECEPTORS Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PYRAZOLE AND PYRIMIDINE ACARICIDES AND INSECTICIDES ACTING AS INHIBITORS OF MITOCHONDRIAL ELECTRON TRANSPORT AT COMPLEX I Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PHENYLPYRAZOLE-CONTAINING FIPROLE INSECTICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PYRAZOLYLPYRIDINE ACTIVATORS OF THE INSECT RYANODINE RECEPTOR Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationships TETRONIC ACID INSECTICIDES AND ACARICIDES INHIBITING ACETYL-COA CARBOXYLASE Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship
IINTRODUCTION THE SIGNIFICANCE OF HETEROCYCLES FOR PHARMACEUTICALS AND AGROCHEMICALS Introduction Heterocycles as Framework of Biologically Active Compounds Fine-Tuning the Physicochemical Properties with Heterocycles Heterocycles as Prodrugs Heterocycles as Peptidomimetics Heterocycles as Isosteric Replacement of Functional Groups Heterocycles as Isosteric Replacement of Alicyclic Rings Heterocycles as Isosteric Replacement of other Heterocyclic Rings PART I: Herbicides TRIAZINE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationships PYRIMIDINYL AND TRIAZINYLSULFONYLUREA HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship ACETOHYDROXYACID SYNTHASE INHIBITING TRIAZOLOPYRIMIDINE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship HPPD-INHIBITING BENZOYLPYRAZOLE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PYRIDYLOXYPHENOXYPROPIONATE HERBICIDES: INHIBITORS OF ACETYL-COA CARBOXYLASE Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationships IMIDAZOLINONE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PROTOPORPHYRINOGEN-IX-OXIDASE-INHIBITING URACIL HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship Part II: Fungicides BENZIMIDAZOLE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship MORPHOLINE FUNGICIDES FOR THE TREATMENT OF POWDERY MILDEW Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship STEROL BIOSYNTHESIS INHIBITING TRIAZOLE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship METHIONINE BIOSYNTHESIS-INHIBITING ANILINOPYRIMIDINE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PHENYLPYRROLE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship BROAD-SPECTRUM FUNGICIDALLY ACTIVE PYRIMIDINYLDIOXY STROBILURINS INHIBITING THE RESPIRATORY CHAIN Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PYRAZOLE CARBOXAMIDE FUNGICIDES INHIBITING SUCCINATE DEHYDROGENASE Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationships Part III: Insecticides AVERMECTIN INSECTICIDES AND ACARICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PYRIDINE AND THIAZOLE-CONTAINING INSECTICIDES AS POTENT AGONISTS ON INSECT NICOTINIC ACETYLCHOLINE RECEPTORS Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PYRAZOLE AND PYRIMIDINE ACARICIDES AND INSECTICIDES ACTING AS INHIBITORS OF MITOCHONDRIAL ELECTRON TRANSPORT AT COMPLEX I Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PHENYLPYRAZOLE-CONTAINING FIPROLE INSECTICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PYRAZOLYLPYRIDINE ACTIVATORS OF THE INSECT RYANODINE RECEPTOR Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationships TETRONIC ACID INSECTICIDES AND ACARICIDES INHIBITING ACETYL-COA CARBOXYLASE Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship