Jonathan Pevsner

Bioinformatics and Functional Genomics (eBook, PDF)

• Format: PDF

Produktbeschreibung

Wiley is proud to announce the publication of the first ever broad-based textbook introduction to Bioinformatics and Functional Genomics by a trained biologist, experienced researcher, and award-winning instructor. In this new text, author Jonathan Pevsner, winner of the 2001 Johns Hopkins University "Teacher of the Year" award, explains problem-solving using bioinformatic approaches using real examples such as breast cancer, HIV-1, and retinal-binding protein throughout. His book includes 375 figures and over 170 tables. Each chapter includes: Problems, discussion of Pitfalls, Boxes explaining key techniques and math/stats principles, Summary, Recommended Reading list, and URLs for freely available software. The text is suitable for professionals and students at every level, including those with little to no background in computer science.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 792
• Erscheinungstermin: 18. Februar 2005
• Englisch
• ISBN-13: 9780471459170
• Artikelnr.: 37301473

Autorenporträt

Jonathan Pevsner received his Ph.D. in Pharmacology and Molecular Sciences at the Johns Hopkins School of Medicine (1989). There, he identified an odorant-binding protein in nasal secretions. He completed postdoctoral training as a Helen Hay Whitney fellow in the Department of Molecular Physiology at the Stanford University Medical Center. At Stanford he identified proteins that function in neurotransmitter release at nerve terminals. In 1995 he joined the faculty in the Department of Neurology at the Kennedy Krieger Institute and the Department of Neuroscience at the Johns Hopkins School of Medicine. He began teaching bioinformatics in 1996, and introduced a ten-week course in 2000. In 2001 the graduate students voted him Teacher of the Year, and in 2003 the Johns Hopkins faculty gave him the Professor's Award for Excellence in Teaching. His lab studies the molecular basis of childhood neurological disorders including autism and Down Syndrome, and develops bioinformatics software.

Inhaltsangabe

Part I Analyzing DNA, RNA, and Protein Sequences
1 Introduction 3
2 Access to Sequence Data and Related Information 19
3 Pairwise Sequence Alignment 69
4 Basic Local Alignment Search Tool (BLAST) 121
5 Advanced Database Searching 167
6 Multiple Sequence Alignment 205
7 Molecular Phylogeny and Evolution 245
Part II Genomewide Analysis of DNA, RNA, and Protein
8 DNA: The Eukaryotic Chromosome 307
9 Analysis of Next-Generation Sequence Data 377
10 Bioinformatic Approaches to Ribonucleic Acid (RNA) 433
11 Gene Expression: Microarray and RNA-seq Data Analysis 479
12 Protein Analysis and Proteomics 539
13 Protein Structure 589
14 Functional Genomics 635
Part III Genome Analysis
15 Genomes Across the Tree of Life 699
16 Completed Genomes: Viruses 755
17 Completed Genomes: Bacteria and Archaea 797
18 Eukaryotic Genomes: Fungi 847
19 Eukaryotic Genomes: From Parasites to Primates 887
20 Human Genome 957
21 Human Disease 1011
Glossary 1075
Self-Test Quiz: Solutions 1103
Author Index 1105
Subject Index 1109