Biological Function of Gangliosides (eBook, PDF)

Redaktion: Svennerholm, L.; Suzuki, K.; Toffano, G.; Tettamanti, G.; Sandhoff, K.; Reisfeld, R. A.; Asbury, A. K.

• Format: PDF

Produktbeschreibung

This book focuses on the role of gangliosides in three areas of medicine in which rapid progress has been made in the last decade: cancer, peripheral neuropathies and Alzheimer's disease. The volume further reflects progress in the pathogenesis of peripheral neuropathies, and the controversial role of gangliosides, also in therapeutic administration. There is a section on the role of gangliosides in neuronal differentiation and development and their receptor functions and cell surface activities. This excellent addition to the renowned Progress in Brain Research series also contains an invaluable plenary lecture on molecular basis of cell adhesion by Nobel prizewinner Gerald Edelman.

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 416
• Erscheinungstermin: 1. Februar 1994
• Englisch
• ISBN-13: 9780080862262
• Artikelnr.: 38013881

Inhaltsangabe

List of contributors. Preface. Designation of schematic structure of
gangliosides and allied glycosphingolipids. 1. Molecular basis of cell
adhesion (Plenary lecture) (Gerald Edelman). Section I - Structure and
metabolism of gangliosides. 2. Ganglioside metabolism: enzymology, topology
and regulation. 3. Developmental regulation of ganglioside metabolism. 4.
New mass spectral approaches to ganglioside structure determinations. 5.
Principles of glycosphingolipid-oligosaccharide constitution. Section II -
Gangliosides in neuronal differentiation and development. 6. Ganglioside
turnover and neural cells function: a new perspective. 7. Gangliosides as
modulators of neuronal calcium. 8. Cell adhesion molecule (NCAM and
N-cadherin) dependent neurite outgrowth is modulated by gangliosides. 9.
Significance of ganglioside-mediated glycosignal transduction in neuronal
differentiation and development. 10. Ca2+-ganglioside-interactions in
neuronal differentiation and development. Section III - Receptor and cell
surface activities of gangliosides. 11. A GM1-ganglioside-binding protein
in rat brain. 12. Receptors for cholera toxin and Escherichia coli
heat-labile enterotoxin revisited. 13. Carbohydrate ligands of leukocyte
adhesion molecules and their therapeutic potential. 14. Receptors for
gangliosides and related glycosphingolipids on central and peripheral
nervous system cell membranes. Section IV - Gangliosides and cancer. 15.
Potential of genetically engineered anti-ganglioside GD2 antibodies for
cancer immunotherapy. 16. Ganglioside phenotype of human gliomas in vivo
and in vitro. 17. Gangliosides associated with primary brain tumors and
their expression in cell lines established from these tumors. 18. Role of
gangliosides in tumor progression. 19. Tumor gangliosides as targets for
active specific immunotherapy of melanoma in man. Section V - Gangliosides
and peripheral neuropathies. 20. Gangliosides and peripheral neuropathies:
an overview. 21. The structure of human anti-ganglioside antibodies. 22.
Antibodies to glycoconjugates in neuropathy and motor neuron disease. 23.
Gangliosides and related glycoconjugates in myelin: relationship to
peripheral neuropathies. 24. Antiglycolipid antibodies and peripheral
neuropathies: link to pathogenesis. Section VI - Gangliosides and
functional recovery of injured nervous system. 25. CNS pharmacology of
gangliosides. 26. Cooperative effects of gangliosides on trophic
factor-induced neuronal cell recovery and synaptogenesis. 27. Gangliosides
in the protection against glutamate excitotoxicity. 28. Clinical approaches
to dementia. 29. Neuropathological changes in Alzheimer disease. 30.
Ganglioside loss is a primary event in Alzheimer's disease Type 1. Subject
index.