Biology of Oligodendrocytes (eBook, PDF)

Redaktion: Armati, Patricia

• Format: PDF

Produktbeschreibung

Traditionally, oligodendrocytes have been assumed to play a minor supporting role in the central nervous system and their importance has generally been overlooked. For the first time, this book provides a dedicated review of all of the major aspects of oligodendrocyte biology, including development, organization, genetics, and immunobiology. Later chapters emphasize the importance of this underestimated cell to the mammalian central nervous system by exploring the role of myelin synthesis and maintenance in neural disease and repair. Particular attention is paid to multiple sclerosis (MS), arguably the prime example of an acquired demyelinating disease, with detailed examinations of the current concepts regarding demyelination, oligodendroglial damage, and remyelination in MS lesions.

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Produktdetails

• Verlag: Cambridge University Press
• Erscheinungstermin: 21. Oktober 2010
• Englisch
• ISBN-13: 9780511796197
• Artikelnr.: 38191582

Inhaltsangabe

List of contributors; Preface; 1. CNS oligarchs. The rise of the
oligodendrocyte in a neuron-centric culture Emily Mathey, Ariel Arthur and
Patricia Armati; 2. Comparative biology of Schwann cells and
oligodendrocytes Rudolf Martini, Janos Groh and Udo Bartsch; 3. Control of
oligodendrocyte development and myelination in the vertebrate CNS Robert H.
Miller; 4. Molecular organization of the oligodendrocyte and myelin Grahame
Kidd and Bruce D. Trapp; 5. The genetics of oligodendrocytes Joseph A.
Nielsen, Pierre Lau and Lynn D. Hudson; 6. Immunobiology of the
oligodendrocyte David Kremer, Orhan Aktas, Hans-Peter Hartung and Patrick
Küry; 7. Oligodendrocytes and disease: repair, remyelination and stem cells
Neil Scolding; 8. Glial progenitor cells and the dynamics of the
oligodendrocyte and its myelin in the aged and injured CNS Jurate Lasiene
and Philip J. Horner; 9. Oligodendroglial pathology in MS Tanja Kuhlmann
and Wolfgang Brück; 10. Glutamate receptors, transporters, and
periventricular leukomalacia Tara M. Desilva and Paul A. Rosenberg;
References; Index.