Biomedical Application of Nanoparticles (eBook, ePUB)

Redaktion: Rihn, Bertrand Henri

• Format: ePub

Produktbeschreibung

This book explores nanoparticles, their chemical and physicals properties, and how they interact in biological systems with proteins, immune systems and targeted cells. Risk assessment of nanoparticles for human use is described, including: cellular paradigms, transcriptomics and toxicogenomics.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 348
• Erscheinungstermin: 5. September 2017
• Englisch
• ISBN-13: 9781351648417
• Artikelnr.: 49261085

Autorenporträt

Bertrand Henri Rihn, MD, DSc, professor of biochemistry and molecular biol-ogy at Lorraine University, France, is a leading expert in the field of particulate toxicology, with research topics including safety toxicology, immunotoxicology, and investigating the transcriptomic changes in macrophages following nanopar-ticle exposure. In addition to his research, Professor Rihn has also worked as a clinical toxicologist, and was awarded the Baratz Award (2004) and the E. Taub Award (2011) from the National Academy of Medicine (France). He also served as the president of the French Society of Toxicology from 2007 to 2009, and was a EUROTOX Registered Toxicologist.

Inhaltsangabe

Variety of nanoparticle their synthesis and physicochemical determination.
Nanoparticle world: history and introduction to their diversity.
Manufacturing nanoparticles: a chemist approach. Manufacturing
nanoparticles: a pharmacist approach. Methods for physico-chemical
composition determination. Metrology of nanoparticles. Interaction with
biological systems. Nanoparticle interaction with proteins: corona
formation. Nanoparticle interaction with immune system. Cell uptake and
internalization. Response of living systems to nanoparticles. Tools and
methods for living system response investigation. Determination of effect
biomarkers in cell, e.g. of NCF1 gene. Oxidative stress pathways involved
following nanoparticle uptake. Involvement of necrosis, apoptosis or
autophagy pathways. Nanoparticle and cell differentiation. Safety
assessment of nanoparticle human use. Rodent inhalation studies for
nanoparticles. The problem of barrier crossing: skin, placenta and brain
barrier. Cell and coculture paradigms in safety assessment. Screening for
genotoxicity using toxicogenomics. Nanoparticle and mitochondrion
interaction. Medical use of nanoparticles. Nanoparticles and drug delivery:
past present and future. Nanoparticles as vehicle of antioxidants.
Nanoparticles in imaging for cancer early diagnosis. Phototherapy using
drug encapsulated agents in cancer. Nanoparticle therapeutic in
degenerative diseases. Nanoparticle in cosmetics. Current use of
nanoparticle in the 3 Pharmacopeia.