Biomotors and their Nanobiotechnology Applications (eBook, ePUB)

Redaktion: Guo, Peixuan; Wang, Aibing

• Format: ePub

Produktbeschreibung

From top academics at First Conference on Biomotors, Virus Assembly, and Nanobiotechnology Applications, this book reviews the mechanistic detail of motor proteins and structural DNA and RNA species, and demonstrates how researchers are beginning to utilize this in-depth knowledge to produce new and exciting advances in nanotechnology.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 436
• Erscheinungstermin: 31. Juli 2023
• Englisch
• ISBN-13: 9780429515378
• Artikelnr.: 68421969

Autorenporträt

Peixuan Guo is the Director of the NIH Nanomedicine Development Center at the University of Cincinnati, Ohio and the Director of the NIH/NCI Cancer Nanotechnology Platform Partnership Program: RNA Nanotechnology for Cancer Therapy at Purdue University, Indiana. He is also a Fellow of the National Academy of Inventors. Aibing Wang is a Molecular Biologist in Department of Oncology, Lombardi Comprehensive cancer center, Georgetown University Medical Center and a chemist in SynerGene Therapeutics, Inc. (SGT).

Inhaltsangabe

1. Biological nanomotors with linear, rotation, or revolution motion
mechanism. 2. Classifications and typical examples of Biomotors. 3.
Structure of revolving biomotors. 4. Structure of rotation motors. 5.
Structure of linear motors. 6. Mechanical Properties of Molecular Motors
and the Relevance to Their Biological Function. 7. Molecular Mechanism of
AAA-ATPase Motor in the 26S Proteasome. 8. General mechanism of biomotors.
9. Mechanism of revolving motors. 10. Mechanism of rotary motors. 11.
Mechanism of linear motors. 12. Finding of widespread viral and bacterial
revolution dsDNA translocation motors distinct from rotation motors by
channel chirality and size. 13. The ATPase of the phi29 DNA packaging motor
is a member of the hexameric AAA+ superfamily. 14. Arginine Finger Serving
as the Starter of Viral DNA Packaging Motors. 15. Three-step channel
conformational changes common to DNA packaging motors of bacterial viruses
T3, T4, SPP1, and Phi29. 16. Sequence Dependence of Reversible CENP-A
Nucleosome Translocation 17. Same function from different structures among
pac site bacteriophage (TerS) terminase small subunits. 18. Kinetic study
of the fidelity of DNA replication with higher-order terminal effects. 19.
Multilevel Control of the Activity of p97/Cdc48, A Versatile Protein
Segregase. 20. High resolution structure of hexameric herpesvirus
DNA-packaging motor elucidates revolving mechanism and ends 20-year fervent
debate. 21. Methods for Single-Molecule Sensing and Detection Using
Bacteriophage Phi29 DNA Packaging Motor. 22. Instrumental design of
five-dimensional single particle tracking. 23. The appropriate ratio of
retroviral structural proteins is activated by the spleen necrosis virus
post-transcriptional control element. 24. Translation of the long-term
fundamental studies on viral DNA packaging motors into nanotechnology and
nanomedicine. 25.Translocation of Peptides through Membrane-Embedded SPP1
Motor Protein Nanopores 26. Insertion of channel of phi29 DNA packaging
motor into polymer membrane for high-throughput sensing. 27.Engineering of
protein nanopores for sequencing, chemical or protein sensing and disease
diagnosis 28. Phage Portal Channels as Nanopore Sensors. 29. Controlled
Co-assembly of Viral Nanoparticles of Simian Virus 40 with Inorganic
Nanoparticles: Strategies and Applications 30. Potential of 3Dpol As An
Enzymatic Reader for Direct RNA Sequencing. 31. Channel from bacterial
virus T7 DNA packaging motor for the differentiation of peptides composed
of a mixture of acidic and basic amino acids. 32. Nano-channel of viral DNA
packaging motor as single pore to differentiate peptides with single amino
acid difference.