Biophysical Techniques in Drug Discovery (eBook, PDF)

Redaktion: Canales, Angeles

• Format: PDF

Produktbeschreibung

Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays.
This book provides an overview of the biophysical methods applied in drug discovery today, including traditional techniques and newer developments. Perspectives from academia and industry across a spectrum of techniques are brought together in a single volume. Small and biotherapeutic approaches are covered and strengths and limitations of each technique are presented. Case studies illustrate the application of each technique in real applied examples. Finally, the book covers recent developments in areas such as electron microscopy with discussions of their possible impact on future drug discovery.
This is a go-to volume for biophysicists, analytical chemists and medicinal chemists providing a broad overview of techniques of contemporary interest in drug discovery.

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Produktdetails

• Verlag: Royal Society of Chemistry
• Seitenzahl: 320
• Erscheinungstermin: 14. November 2017
• Englisch
• ISBN-13: 9781788010016
• Artikelnr.: 50463395

Inhaltsangabe

Impact and Evolution of Biophysics in Medicinal Chemistry
Ligand-Detected NMR Methods in Drug Discovery
Receptor based NMR techniques in Drug Discovery
Molecular Mechanisms of Drug Action: X-ray Crystallography at the Basis of Structure-based and Ligand-based Drug Design
Mass Spectrometry in Biophysics: from High Throughput Screening to Structural Biology
Characterization of Pharmaceutical Solids Combining NMR, X-ray Diffraction and Computer Modelling
Surface Plasmon Resonance for Identifying and Characterising Small Molecule Ligands
Fluorescent Thermal Shift Assays for Identifying Small Molecule Ligands
Fluorescent Probes in Medicinal Chemistry
Transmission Cryo-Electron Microscopy in Drug Discovery
Molecular Imaging
Subject Index