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Discover a comprehensive and current overview of microbial bioprospecting written by leading voices in the field In Bioprospecting of Microorganism-Based Industrial Molecules, distinguished researchers and authors Sudhir P. Singh and Santosh Kumar Upadhyay deliver global perspectives of bioprospecting of biodiversity. The book covers diverse aspects of bioprospecting of microorganisms demonstrating biomass value of nutraceutical, pharmaceutical, biomedical, and bioenergetic importance. The authors present an amalgamation of translational research on bioresource utilization and ecological…mehr
Discover a comprehensive and current overview of microbial bioprospecting written by leading voices in the field In Bioprospecting of Microorganism-Based Industrial Molecules, distinguished researchers and authors Sudhir P. Singh and Santosh Kumar Upadhyay deliver global perspectives of bioprospecting of biodiversity. The book covers diverse aspects of bioprospecting of microorganisms demonstrating biomass value of nutraceutical, pharmaceutical, biomedical, and bioenergetic importance. The authors present an amalgamation of translational research on bioresource utilization and ecological sustainability that will further the reader's knowledge of the applications of different microbial diversity and reveal new avenues of research investigation. Readers will also benefit from: * A thorough introduction to microbial biodiversity and bioprospecting * An exploration of anti-ageing and skin lightening microbial products and microbial production of anti-cancerous biomolecules * A treatment of UV protective compounds from algal biodiversity and polysaccharides from marine microalgal sources * Discussions of microbial sources of insect toxic proteins and the role of microbes in bio-surfactants production Perfect for academics, scientists, researchers, graduate and post-graduate students working and studying in the areas of microbiology, food biotechnology, industrial microbiology, plant biotechnology, and microbial biotechnology, Bioprospecting of Microorganism-Based Industrial Molecules is an indispensable guide for anyone looking for a comprehensive overview of the subject.
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Autorenporträt
Sudhir P. Singh, Scientist-D, Biotechnology & Synthetic Biology, Center of Innovative and Applied Bioprocessing, Mohali, India. He has been working in the field of molecular biology and biotechnology for more than a decade. His current research is focused on gene mining and biocatalyst engineering for the development of approaches for transformation of agro-industrial residues and under- or un-utilized side-stream biomass into value-added bio-products. Santosh Kumar Upadhyay, Assistant Professor, Department of Botany, Panjab University, Chandigarh, India. He has been working in the field of plant biotechnology for more than 14 years. His current research focuses on functional genomics.
Inhaltsangabe
About the Editors xvi
List of Contributors xviii
Preface xxiii
Acknowledgments xxiv
1 An Introduction to Microbial Biodiversity and Bioprospection 1 Tomoya Shintani, Santosh Kumar Upadhyay, and Sudhir P. Singh
1.1 Introduction 1
1.2 Conclusions and Perspectives 3
Acknowledgment 4
References 4
2 Application of Microorganisms in Biosurfactant Production 6 Lorena Pedraza-Segura, Luis V. Rodríguez-Durán, Gerardo Saucedo- Castañeda, and José de Jesús Cázares-Marinero
2.1 Biosurfactants Nature and Classification 6
2.2 Biosynthesis of BS by Archaea and Bacteria 12
2.3 Biosynthesis of BS by Yeasts and Molds 14
2.4 Screening for BS Producers 15
2.5 A Case Study: SL by Solid-State Fermentation (SSF), Kinetics, and Reactor Size Estimation 16
2.6 Conclusions and Perspectives 23
References 24
3 Microbial Gums: Current Trends and Applications 31 Rwivoo Baruah and Prakash M. Halami
3.1 Introduction 31
3.2 Biosynthesis of Microbial Gums 32
3.3 Production of Microbial Gums 33
3.4 Structure and Properties of Microbial Gums 34
3.5 Types of Microbial Gums 34
3.6 Applications of Microbial Gums 39
3.7 Conclusions and Perspectives 42
Acknowledgments 43
References 43
4 Antiaging and Skin Lightening Microbial Products 47 Prabuddha Gupta, Ujwalkumar Trivedi, Mahendrapalsingh Rajput,Tejas Oza, Jasmita Chauhan, and Gaurav Sanghvi
4.1 Introduction 47
4.2 Aging 48
4.3 Extrinsic Skin Aging Factors 52
4.4 Why Microbes 53
4.5 Conclusions and Perspectives 67
References 68
5 Application of Microorganisms in Bioremediation 77 Himani Thakkar and Vinnyfred Vincent
5.1 Introduction 77
5.2 Microbial Bioremediation 78
5.3 Microbial Bioremediation of Organic Pollutants 79
5.4 Microbial Degradation of Heavy Metals 87
5.5 Factors Affecting Bioremediation 89
5.6 Advances in Bioremediation 91
5.7 Conclusions and Perspectives 94
References 95
6 Microbial Applications in Organic Acid Production 104 Jyoti Singh Jadaun, Amit K. Rai, and Sudhir P. Singh
6.1 Introduction 104
6.2 Glycolic acid (2C) 105
6.3 Acetic Acid (2C) 108
6.4 Pyruvic Acid (3C) 108
6.5 Lactic Acid (3C) 109
6.6 Succinic Acid (4C) 109
6.7 Fumaric Acid (4C) 110
6.8 Malic Acid (4C) 111
6.9 Itaconic Acid (5C) 112
6.10 Gluconic Acid (6C) 113
6.11 Citric Acid (6C) 114
6.12 Kojic Acid (6C) 114
6.13 Muconic and Adipic Acid (C6) 115
6.14 Conclusions and Perspectives 117
Acknowledgments 117
References 117
7 Production of Bioactive Compounds vs. Recombinant Proteins 125 Maria F. Salazar Affonso, Débora Bublitz Anton, Daniel Kuhn, Bruno Dahmer, Camile Wünsch, Verônica Contini, Luís F. Saraiva Macedo Timmers, Claucia F. Volken de Souza, Márcia I. Goettert, and Rodrigo G. Ducati
7.1 Introduction 125
7.2 In vitro Cell-Based Assays 126
7.3 Cell Viability Assays 127
7.4 Cell Metabolic Assays 127
7.5 Cell Survival Assays 128
7.6 Cell Transformation Assays 129
7.7 Cell Irritation Assays 129
7.8 Heterologous Expression of Recombinant Proteins of Biomedical Relevance 130
7.9 Lactic Acid Bacteria and the Production of Metabolites with Therapeutic Roles 132
1 An Introduction to Microbial Biodiversity and Bioprospection 1 Tomoya Shintani, Santosh Kumar Upadhyay, and Sudhir P. Singh
1.1 Introduction 1
1.2 Conclusions and Perspectives 3
Acknowledgment 4
References 4
2 Application of Microorganisms in Biosurfactant Production 6 Lorena Pedraza-Segura, Luis V. Rodríguez-Durán, Gerardo Saucedo- Castañeda, and José de Jesús Cázares-Marinero
2.1 Biosurfactants Nature and Classification 6
2.2 Biosynthesis of BS by Archaea and Bacteria 12
2.3 Biosynthesis of BS by Yeasts and Molds 14
2.4 Screening for BS Producers 15
2.5 A Case Study: SL by Solid-State Fermentation (SSF), Kinetics, and Reactor Size Estimation 16
2.6 Conclusions and Perspectives 23
References 24
3 Microbial Gums: Current Trends and Applications 31 Rwivoo Baruah and Prakash M. Halami
3.1 Introduction 31
3.2 Biosynthesis of Microbial Gums 32
3.3 Production of Microbial Gums 33
3.4 Structure and Properties of Microbial Gums 34
3.5 Types of Microbial Gums 34
3.6 Applications of Microbial Gums 39
3.7 Conclusions and Perspectives 42
Acknowledgments 43
References 43
4 Antiaging and Skin Lightening Microbial Products 47 Prabuddha Gupta, Ujwalkumar Trivedi, Mahendrapalsingh Rajput,Tejas Oza, Jasmita Chauhan, and Gaurav Sanghvi
4.1 Introduction 47
4.2 Aging 48
4.3 Extrinsic Skin Aging Factors 52
4.4 Why Microbes 53
4.5 Conclusions and Perspectives 67
References 68
5 Application of Microorganisms in Bioremediation 77 Himani Thakkar and Vinnyfred Vincent
5.1 Introduction 77
5.2 Microbial Bioremediation 78
5.3 Microbial Bioremediation of Organic Pollutants 79
5.4 Microbial Degradation of Heavy Metals 87
5.5 Factors Affecting Bioremediation 89
5.6 Advances in Bioremediation 91
5.7 Conclusions and Perspectives 94
References 95
6 Microbial Applications in Organic Acid Production 104 Jyoti Singh Jadaun, Amit K. Rai, and Sudhir P. Singh
6.1 Introduction 104
6.2 Glycolic acid (2C) 105
6.3 Acetic Acid (2C) 108
6.4 Pyruvic Acid (3C) 108
6.5 Lactic Acid (3C) 109
6.6 Succinic Acid (4C) 109
6.7 Fumaric Acid (4C) 110
6.8 Malic Acid (4C) 111
6.9 Itaconic Acid (5C) 112
6.10 Gluconic Acid (6C) 113
6.11 Citric Acid (6C) 114
6.12 Kojic Acid (6C) 114
6.13 Muconic and Adipic Acid (C6) 115
6.14 Conclusions and Perspectives 117
Acknowledgments 117
References 117
7 Production of Bioactive Compounds vs. Recombinant Proteins 125 Maria F. Salazar Affonso, Débora Bublitz Anton, Daniel Kuhn, Bruno Dahmer, Camile Wünsch, Verônica Contini, Luís F. Saraiva Macedo Timmers, Claucia F. Volken de Souza, Márcia I. Goettert, and Rodrigo G. Ducati
7.1 Introduction 125
7.2 In vitro Cell-Based Assays 126
7.3 Cell Viability Assays 127
7.4 Cell Metabolic Assays 127
7.5 Cell Survival Assays 128
7.6 Cell Transformation Assays 129
7.7 Cell Irritation Assays 129
7.8 Heterologous Expression of Recombinant Proteins of Biomedical Relevance 130
7.9 Lactic Acid Bacteria and the Production of Metabolites with Therapeutic Roles 132
7.10 Preclinical Studies 134
7.11 Computer- aided
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