Bioreactors for Stem Cell Expansion and Differentiation (eBook, PDF)

Redaktion: Cabral, Joaquim M. S.; Lobato Da Silva, Claudia

• Format: PDF

Produktbeschreibung

The authors offer novel insights into bioreactor-based culture systems specific for tissue engineering, including sophisticated and cost-effective manufacturing strategies geared to overcome technological shortcomings that currently preclude advances towards product commercialization.

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 356
• Erscheinungstermin: 3. September 2018
• Englisch
• ISBN-13: 9780429841828
• Artikelnr.: 54274130

Autorenporträt

Joaquim M.S. Cabral is a Professor of Biological Engineering, in the Department of Bioengineering at Instituto Superior Técnico (IST), University of Lisbon, Portugal. He is the founding head of department and director of the Institute for Bioengineering and Biosciences. Joaquim Cabral's research focuses on novel developments in bioprocess engineering and stem cell bioengineering. His research includes stem cell bioprocessing and manufacturing, addressing the ex-vivo expansion, controlled differentiation and purification of hematopoietic stem cells, mesenchymal stem cells, and pluripotent stem cells (both ESC and iPSC). Claudia Lobato da Silva is an Assistant Professor in the Department of Bioengineering, Instituto Superior Técnico, University of Lisbon, Portugal. Her research interests involve the development of novel methods to isolate and purify stem cells, and establish optimal conditions for the maximization of expansion of umbilical cord blood-derived hematopoietic stem/progenitor cells, as well as developing bioreactor strategies for the clinical-scale production of mesenchymal stem/stromal cells from different human sources.

Inhaltsangabe

Expansion of human pluripotent stem cells in microcarrier-based culture
systems. Large-scale culture of 3D aggregates of pluripotent stem cells.
Cardiac differentiation of human pluripotent stem cells in scalable
suspension culture. Integrated processes for expansion and differentiation
of human pluripotent stem cells into neural progenitor cells. Bioreactor
protocols for human neural precursor cell expansion. Expansion of human
cardiac progenitor cells in using microcarriers. Differentiation of
embryonic stem cells towards red blood cell production. Expansion of
hematopoietic progenitor cells in a hollow fiber bioreactor system.
Engineering the bone marrow niche for platelet generation ex vivo and
modeling of megakaryopoiesis. Packed Bed Bioreactor for the Isolation and
Expansion of Human Mesenchymal Stem/Stromal Cells. Expansion of human
mesenchymal stem/stromal cells in microcarrier-based culture systems.
Scaffold-based perfusion bioreactors for Cell Therapies and Tissue
Engineering. Vascular Tissue Engineering. Bioreactor design for bone and
cartilage tissue engineering. Engineering cardiac tissue in bioreactors.
Organ-level tissue engineering using bioreactor systems and stem cells.
Kidney Tissue Engineering. Liver Tissue Engineering. Bioprocess monitoring
in tissue engineering perfusion bioreactors. Bioprocessing of human stem
cells for therapeutic use through single-use bioreactors.