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An interdisciplinary approach to one of the hottest topics in nanotechnology and nanoscience Biosensing Using Nanomaterials introduces novel concepts in the area of bioanalysis based on nanomaterials, opening new opportunities for basic research and new tools for real bioanalytical applications. In fifteen chapters, readers are introduced to the most successful nanomaterials used so far in biosensing, including carbon nanotubes, nanoparticles, and nanochannels. Each chapter provides a theoretical overview of the topic, a discussion of the published data relating to the bioanalytical system,…mehr
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An interdisciplinary approach to one of the hottest topics in nanotechnology and nanoscience Biosensing Using Nanomaterials introduces novel concepts in the area of bioanalysis based on nanomaterials, opening new opportunities for basic research and new tools for real bioanalytical applications. In fifteen chapters, readers are introduced to the most successful nanomaterials used so far in biosensing, including carbon nanotubes, nanoparticles, and nanochannels. Each chapter provides a theoretical overview of the topic, a discussion of the published data relating to the bioanalytical system, and a selected list of references for further investigation. The result is a book that provides a comprehensive forum of interest to scientists, engineers, researchers, manufacturers, teachers, and students. Biosensing Using Nanomaterials is an important resource for a broad audience involved in the research, teaching, learning, and practice of integrating nanomaterials into biosensing systems for clinical, environmental, and industrial applications.
Produktdetails
- Produktdetails
- Verlag: John Wiley & Sons
- Seitenzahl: 520
- Erscheinungstermin: 31. März 2009
- Englisch
- ISBN-13: 9780470447727
- Artikelnr.: 37292355
- Verlag: John Wiley & Sons
- Seitenzahl: 520
- Erscheinungstermin: 31. März 2009
- Englisch
- ISBN-13: 9780470447727
- Artikelnr.: 37292355
Arben Merkoçi, PhD, is ICREA Research Professor and Group Leader of Nanobioelectronics & Biosensors Group at Institut Català de Nanotecnologia in Spain.?His research is aimed at the integration of biological molecules into micro- and nanostructures, with state-of-the-art bioelectronic read-out systems, extracting useful analytical signals with interest for various fields. Professor Merkoçi is the author of more than 200 refereed journal or conference papers, two books, five book chapters, and the editor of special international journal issues on nanomaterials. He has one patent in the field of nanomaterials-based biosensing systems.
CONTRIBUTORS. SERIES PREFACE. PREFACE. PART I CARBON NANOTUBES. 1. Carbon
Nanotube-Based Sensors and Biosensors (Richard G. Compton, Gregory G.
Wildgoose, and Elicia L. S. Wong). 1.1. Introduction to the Structure of
Carbon Nanotubes. 1.2. Electroanalysis Using CNT-Modified Electrodes. 1.3.
Advantageous Application of CNTs in Sensors: pH Sensing. 1.4. Carbon
Nanotube-Based Biosensors. 1.5. Using CNTs in Biosensor Production for
Medical Diagnostics and Environmental Applications. References. 2.
Isotropic Display of Biomolecules on CNT-Arrayed Nanostructures (Mark R.
Contarino, Gary Withey, and Irwin Chaiken). 2.1. Introduction: CNT Arrays
for Biosensing. 2.2. Functionalization of CNTs: Controlling Display Through
Covalent Attachment. 2.3. Self-Assembling Interfaces: Anchor-Probe
Approach. 2.4. Molecular Wiring of Redox Enzymes. 2.5. Multiplexing
Biomolecules on Nanoscale CNT Arrays. 2.6. Conclusions. References. 3.
Interaction of DNA with CNTs: Properties and Prospects for Electronic
Sequencing (Sheng Meng and Efthimios Kaxiras). 3.1. Introduction. 3.2.
Structural Properties of Combined DNA-CNT Systems. 3.3. Electronic
Structure. 3.4. Optical Properties. 3.5. Biosensing and Sequencing of DNA
Using CNTs. 3.6. Summary. References. PART II NANOPARTICLES. 4. Improved
Electrochemistry of Biomolecules Using Nanomaterials (Jianxiu Wang, Andrew
J. Wain, Xu Zhu, and Feimeng Zhou). 4.1. Introduction. 4.2. CNT-Based
Electrochemical Biosensors. 4.3. Nanoparticle-Based Electrochemical
Biosensors. 4.4. Quantum Dot-Based Electrochemical Biosensors. 4.5.
Conclusions and Outlook. References. 5. The Metal Nanoparticle Plasmon Band
as a Powerful Tool for Chemo- and Biosensing (Audrey Moores and Pascal Le
Floch). 5.1. Introduction. 5.2. The SPB: An Optical Property of Metal NPs.
5.3. Plasmon Band Variation Upon Aggregation of Nanoparticles. 5.4. Plasmon
Band Variation on the Environment or Ligand Alteration. 5.5. Metal
Nanoparticles as Labels. 5.6. Conclusions. References. 6. Gold
Nanoparticles: A Versatile Label for Affinity Electrochemical Biosensors
(Adriano Ambrosi, Alfredo de la Escosura-MunÜ iz, Maria Teresa Castaneda,
and Arben Merkoci). 6.1. Introduction. 6.2. Synthesis of AuNPs. 6.3.
Characterization of AuNPs. 6.4. AuNPs as Detecting Labels for Affinity
Biosensors. 6.5. Conclusions. References. 7. Quantum Dots for the
Development of Optical Biosensors Based on Fluorescence (W. Russ Algar and
Ulrich J. Krull). 7.1. Introduction. 7.2. Quantum Dots. 7.3. Basic
Photophysics and Quantum Confinement. 7.4. Quantum Dot Surface Chemistry
and Bioconjugation. 7.5. Bioanalytical Applications of Quantum Dots as
Fluorescent Labels. 7.6. Fluorescence Resonance Energy Transfer and Quantum
Dot Biosensing. 7.7. Summary. References. 8. Nanoparticle-Based Delivery
and Biosensing Systems: An Example (Almudena MunÜoz Javier, Pablo del Pino,
Stefan Kudera, and Wolfgang J. Parak). 8.1. Introduction. 8.2. Functional
Colloidal Nanoparticles. 8.3. Polyelectrolyte Capsules as a Functional
Carrier System. 8.4. Uptake of Capsules by Cells. 8.5. Delivery and Sensing
with Polyelectrolyte Capsules. 8.6. Conclusions. References. 9. Luminescent
Quantum Dot FRET-Based Probes in Cellular and Biological Assays (Lifang
Shi, Nitsa Rosenzweig, and Zeev Rosenzweig). 9.1. Introduction. 9.2.
Luminescent Quantum Dots. 9.3. Fluorescence Resonance Energy Transfer. 9.4.
Quantum Dot FRET-Based Protease Probes. 9.5. Summary and Conclusions.
References. 10. Quantum Dot-Polymer Bead Composites for Biological Sensing
Applications (Jonathan M. Behrendt and Andrew J. Sutherland). 10.1.
Introduction. 10.2. Quantum Dot-Composite Construction. 10.3. Applications
of QD Composites. 10.4. Future Directions. References. 11. Quantum Dot
Applications in Biomolecule Assays (Ying Xu, Pingang He, and Yuzhi Fang).
11.1. Introduction to QDs and Their Applications. 11.2. Preparation of QDs
for Conjugation with Biomolecules and Cells. 11.3. Special Optoelectronic
Properties in the Bioemployment of QDs. 11.4. Employment of QDs as
Biosensing Indicators. References. 12. Nanoparticles and Inductively
Coupled Plasma Mass Spectroscopy-Based Biosensing (Arben Merkoc¿i, Roza
Allabashi, and Alfredo de la Escosura-Muniz). 12.1. ICP-MS and Application
Possibilities. 12.2. Detection of Metal Ions. 12.3. Detection of
Nanoparticles. 12.4. Analysis of Metal-Containing Biomolecules. 12.5.
Bioanalysis Based on Labeling with Metal Nanoparticles. 12.6. Conclusions.
References. PART III NANOSTRUCTURED SURFACES. 13. Integration Between
Template-Based Nanostructured Surfaces and Biosensors (Walter Vastarella,
Jan Maly, Mihaela Ilie, and Roberto Pilloton). 13.1. Introduction. 13.2.
Nanosphere Lithography. 13.3. Nanoelectrodes Ensemble for Biosensing
Devices. 13.4. Concluding Remarks. References. 14. Nanostructured Affinity
Surfaces for MALDI-TOF-MS-Based Protein Profiling and Biomarker Discovery
(R. M. Vallant, M. Rainer, M. Najam-Ul-Haq, R. Bakry, C. Petter, N. Heigl,
G. K. Bonn, and C. W. Huck). 14.1. Proteomics and Biomarkers. 14.2. MALDI
in Theory and Practice. 14.3. Carbon Nanomaterials. 14.4. Near-Infrared
Diffuse Reflection Spectroscopy of Carbon Nanomaterials. References. PART
IV NANOPORES. 15. Biosensing with Nanopores (Ivan Vlassiouk and Sergei
Smirnov). 15.1. Nanoporous Materials in Sensing. 15.2. Nanochannel and
Nanopore Fabrication. 15.3. Surface Modification Chemistry 15.4.
Nonelectrical Nanoporous Biosensors. 15.5. Electrical Nanoporous
Biosensors. 15.6. Summary. References. INDEX.
Nanotube-Based Sensors and Biosensors (Richard G. Compton, Gregory G.
Wildgoose, and Elicia L. S. Wong). 1.1. Introduction to the Structure of
Carbon Nanotubes. 1.2. Electroanalysis Using CNT-Modified Electrodes. 1.3.
Advantageous Application of CNTs in Sensors: pH Sensing. 1.4. Carbon
Nanotube-Based Biosensors. 1.5. Using CNTs in Biosensor Production for
Medical Diagnostics and Environmental Applications. References. 2.
Isotropic Display of Biomolecules on CNT-Arrayed Nanostructures (Mark R.
Contarino, Gary Withey, and Irwin Chaiken). 2.1. Introduction: CNT Arrays
for Biosensing. 2.2. Functionalization of CNTs: Controlling Display Through
Covalent Attachment. 2.3. Self-Assembling Interfaces: Anchor-Probe
Approach. 2.4. Molecular Wiring of Redox Enzymes. 2.5. Multiplexing
Biomolecules on Nanoscale CNT Arrays. 2.6. Conclusions. References. 3.
Interaction of DNA with CNTs: Properties and Prospects for Electronic
Sequencing (Sheng Meng and Efthimios Kaxiras). 3.1. Introduction. 3.2.
Structural Properties of Combined DNA-CNT Systems. 3.3. Electronic
Structure. 3.4. Optical Properties. 3.5. Biosensing and Sequencing of DNA
Using CNTs. 3.6. Summary. References. PART II NANOPARTICLES. 4. Improved
Electrochemistry of Biomolecules Using Nanomaterials (Jianxiu Wang, Andrew
J. Wain, Xu Zhu, and Feimeng Zhou). 4.1. Introduction. 4.2. CNT-Based
Electrochemical Biosensors. 4.3. Nanoparticle-Based Electrochemical
Biosensors. 4.4. Quantum Dot-Based Electrochemical Biosensors. 4.5.
Conclusions and Outlook. References. 5. The Metal Nanoparticle Plasmon Band
as a Powerful Tool for Chemo- and Biosensing (Audrey Moores and Pascal Le
Floch). 5.1. Introduction. 5.2. The SPB: An Optical Property of Metal NPs.
5.3. Plasmon Band Variation Upon Aggregation of Nanoparticles. 5.4. Plasmon
Band Variation on the Environment or Ligand Alteration. 5.5. Metal
Nanoparticles as Labels. 5.6. Conclusions. References. 6. Gold
Nanoparticles: A Versatile Label for Affinity Electrochemical Biosensors
(Adriano Ambrosi, Alfredo de la Escosura-MunÜ iz, Maria Teresa Castaneda,
and Arben Merkoci). 6.1. Introduction. 6.2. Synthesis of AuNPs. 6.3.
Characterization of AuNPs. 6.4. AuNPs as Detecting Labels for Affinity
Biosensors. 6.5. Conclusions. References. 7. Quantum Dots for the
Development of Optical Biosensors Based on Fluorescence (W. Russ Algar and
Ulrich J. Krull). 7.1. Introduction. 7.2. Quantum Dots. 7.3. Basic
Photophysics and Quantum Confinement. 7.4. Quantum Dot Surface Chemistry
and Bioconjugation. 7.5. Bioanalytical Applications of Quantum Dots as
Fluorescent Labels. 7.6. Fluorescence Resonance Energy Transfer and Quantum
Dot Biosensing. 7.7. Summary. References. 8. Nanoparticle-Based Delivery
and Biosensing Systems: An Example (Almudena MunÜoz Javier, Pablo del Pino,
Stefan Kudera, and Wolfgang J. Parak). 8.1. Introduction. 8.2. Functional
Colloidal Nanoparticles. 8.3. Polyelectrolyte Capsules as a Functional
Carrier System. 8.4. Uptake of Capsules by Cells. 8.5. Delivery and Sensing
with Polyelectrolyte Capsules. 8.6. Conclusions. References. 9. Luminescent
Quantum Dot FRET-Based Probes in Cellular and Biological Assays (Lifang
Shi, Nitsa Rosenzweig, and Zeev Rosenzweig). 9.1. Introduction. 9.2.
Luminescent Quantum Dots. 9.3. Fluorescence Resonance Energy Transfer. 9.4.
Quantum Dot FRET-Based Protease Probes. 9.5. Summary and Conclusions.
References. 10. Quantum Dot-Polymer Bead Composites for Biological Sensing
Applications (Jonathan M. Behrendt and Andrew J. Sutherland). 10.1.
Introduction. 10.2. Quantum Dot-Composite Construction. 10.3. Applications
of QD Composites. 10.4. Future Directions. References. 11. Quantum Dot
Applications in Biomolecule Assays (Ying Xu, Pingang He, and Yuzhi Fang).
11.1. Introduction to QDs and Their Applications. 11.2. Preparation of QDs
for Conjugation with Biomolecules and Cells. 11.3. Special Optoelectronic
Properties in the Bioemployment of QDs. 11.4. Employment of QDs as
Biosensing Indicators. References. 12. Nanoparticles and Inductively
Coupled Plasma Mass Spectroscopy-Based Biosensing (Arben Merkoc¿i, Roza
Allabashi, and Alfredo de la Escosura-Muniz). 12.1. ICP-MS and Application
Possibilities. 12.2. Detection of Metal Ions. 12.3. Detection of
Nanoparticles. 12.4. Analysis of Metal-Containing Biomolecules. 12.5.
Bioanalysis Based on Labeling with Metal Nanoparticles. 12.6. Conclusions.
References. PART III NANOSTRUCTURED SURFACES. 13. Integration Between
Template-Based Nanostructured Surfaces and Biosensors (Walter Vastarella,
Jan Maly, Mihaela Ilie, and Roberto Pilloton). 13.1. Introduction. 13.2.
Nanosphere Lithography. 13.3. Nanoelectrodes Ensemble for Biosensing
Devices. 13.4. Concluding Remarks. References. 14. Nanostructured Affinity
Surfaces for MALDI-TOF-MS-Based Protein Profiling and Biomarker Discovery
(R. M. Vallant, M. Rainer, M. Najam-Ul-Haq, R. Bakry, C. Petter, N. Heigl,
G. K. Bonn, and C. W. Huck). 14.1. Proteomics and Biomarkers. 14.2. MALDI
in Theory and Practice. 14.3. Carbon Nanomaterials. 14.4. Near-Infrared
Diffuse Reflection Spectroscopy of Carbon Nanomaterials. References. PART
IV NANOPORES. 15. Biosensing with Nanopores (Ivan Vlassiouk and Sergei
Smirnov). 15.1. Nanoporous Materials in Sensing. 15.2. Nanochannel and
Nanopore Fabrication. 15.3. Surface Modification Chemistry 15.4.
Nonelectrical Nanoporous Biosensors. 15.5. Electrical Nanoporous
Biosensors. 15.6. Summary. References. INDEX.
CONTRIBUTORS. SERIES PREFACE. PREFACE. PART I CARBON NANOTUBES. 1. Carbon
Nanotube-Based Sensors and Biosensors (Richard G. Compton, Gregory G.
Wildgoose, and Elicia L. S. Wong). 1.1. Introduction to the Structure of
Carbon Nanotubes. 1.2. Electroanalysis Using CNT-Modified Electrodes. 1.3.
Advantageous Application of CNTs in Sensors: pH Sensing. 1.4. Carbon
Nanotube-Based Biosensors. 1.5. Using CNTs in Biosensor Production for
Medical Diagnostics and Environmental Applications. References. 2.
Isotropic Display of Biomolecules on CNT-Arrayed Nanostructures (Mark R.
Contarino, Gary Withey, and Irwin Chaiken). 2.1. Introduction: CNT Arrays
for Biosensing. 2.2. Functionalization of CNTs: Controlling Display Through
Covalent Attachment. 2.3. Self-Assembling Interfaces: Anchor-Probe
Approach. 2.4. Molecular Wiring of Redox Enzymes. 2.5. Multiplexing
Biomolecules on Nanoscale CNT Arrays. 2.6. Conclusions. References. 3.
Interaction of DNA with CNTs: Properties and Prospects for Electronic
Sequencing (Sheng Meng and Efthimios Kaxiras). 3.1. Introduction. 3.2.
Structural Properties of Combined DNA-CNT Systems. 3.3. Electronic
Structure. 3.4. Optical Properties. 3.5. Biosensing and Sequencing of DNA
Using CNTs. 3.6. Summary. References. PART II NANOPARTICLES. 4. Improved
Electrochemistry of Biomolecules Using Nanomaterials (Jianxiu Wang, Andrew
J. Wain, Xu Zhu, and Feimeng Zhou). 4.1. Introduction. 4.2. CNT-Based
Electrochemical Biosensors. 4.3. Nanoparticle-Based Electrochemical
Biosensors. 4.4. Quantum Dot-Based Electrochemical Biosensors. 4.5.
Conclusions and Outlook. References. 5. The Metal Nanoparticle Plasmon Band
as a Powerful Tool for Chemo- and Biosensing (Audrey Moores and Pascal Le
Floch). 5.1. Introduction. 5.2. The SPB: An Optical Property of Metal NPs.
5.3. Plasmon Band Variation Upon Aggregation of Nanoparticles. 5.4. Plasmon
Band Variation on the Environment or Ligand Alteration. 5.5. Metal
Nanoparticles as Labels. 5.6. Conclusions. References. 6. Gold
Nanoparticles: A Versatile Label for Affinity Electrochemical Biosensors
(Adriano Ambrosi, Alfredo de la Escosura-MunÜ iz, Maria Teresa Castaneda,
and Arben Merkoci). 6.1. Introduction. 6.2. Synthesis of AuNPs. 6.3.
Characterization of AuNPs. 6.4. AuNPs as Detecting Labels for Affinity
Biosensors. 6.5. Conclusions. References. 7. Quantum Dots for the
Development of Optical Biosensors Based on Fluorescence (W. Russ Algar and
Ulrich J. Krull). 7.1. Introduction. 7.2. Quantum Dots. 7.3. Basic
Photophysics and Quantum Confinement. 7.4. Quantum Dot Surface Chemistry
and Bioconjugation. 7.5. Bioanalytical Applications of Quantum Dots as
Fluorescent Labels. 7.6. Fluorescence Resonance Energy Transfer and Quantum
Dot Biosensing. 7.7. Summary. References. 8. Nanoparticle-Based Delivery
and Biosensing Systems: An Example (Almudena MunÜoz Javier, Pablo del Pino,
Stefan Kudera, and Wolfgang J. Parak). 8.1. Introduction. 8.2. Functional
Colloidal Nanoparticles. 8.3. Polyelectrolyte Capsules as a Functional
Carrier System. 8.4. Uptake of Capsules by Cells. 8.5. Delivery and Sensing
with Polyelectrolyte Capsules. 8.6. Conclusions. References. 9. Luminescent
Quantum Dot FRET-Based Probes in Cellular and Biological Assays (Lifang
Shi, Nitsa Rosenzweig, and Zeev Rosenzweig). 9.1. Introduction. 9.2.
Luminescent Quantum Dots. 9.3. Fluorescence Resonance Energy Transfer. 9.4.
Quantum Dot FRET-Based Protease Probes. 9.5. Summary and Conclusions.
References. 10. Quantum Dot-Polymer Bead Composites for Biological Sensing
Applications (Jonathan M. Behrendt and Andrew J. Sutherland). 10.1.
Introduction. 10.2. Quantum Dot-Composite Construction. 10.3. Applications
of QD Composites. 10.4. Future Directions. References. 11. Quantum Dot
Applications in Biomolecule Assays (Ying Xu, Pingang He, and Yuzhi Fang).
11.1. Introduction to QDs and Their Applications. 11.2. Preparation of QDs
for Conjugation with Biomolecules and Cells. 11.3. Special Optoelectronic
Properties in the Bioemployment of QDs. 11.4. Employment of QDs as
Biosensing Indicators. References. 12. Nanoparticles and Inductively
Coupled Plasma Mass Spectroscopy-Based Biosensing (Arben Merkoc¿i, Roza
Allabashi, and Alfredo de la Escosura-Muniz). 12.1. ICP-MS and Application
Possibilities. 12.2. Detection of Metal Ions. 12.3. Detection of
Nanoparticles. 12.4. Analysis of Metal-Containing Biomolecules. 12.5.
Bioanalysis Based on Labeling with Metal Nanoparticles. 12.6. Conclusions.
References. PART III NANOSTRUCTURED SURFACES. 13. Integration Between
Template-Based Nanostructured Surfaces and Biosensors (Walter Vastarella,
Jan Maly, Mihaela Ilie, and Roberto Pilloton). 13.1. Introduction. 13.2.
Nanosphere Lithography. 13.3. Nanoelectrodes Ensemble for Biosensing
Devices. 13.4. Concluding Remarks. References. 14. Nanostructured Affinity
Surfaces for MALDI-TOF-MS-Based Protein Profiling and Biomarker Discovery
(R. M. Vallant, M. Rainer, M. Najam-Ul-Haq, R. Bakry, C. Petter, N. Heigl,
G. K. Bonn, and C. W. Huck). 14.1. Proteomics and Biomarkers. 14.2. MALDI
in Theory and Practice. 14.3. Carbon Nanomaterials. 14.4. Near-Infrared
Diffuse Reflection Spectroscopy of Carbon Nanomaterials. References. PART
IV NANOPORES. 15. Biosensing with Nanopores (Ivan Vlassiouk and Sergei
Smirnov). 15.1. Nanoporous Materials in Sensing. 15.2. Nanochannel and
Nanopore Fabrication. 15.3. Surface Modification Chemistry 15.4.
Nonelectrical Nanoporous Biosensors. 15.5. Electrical Nanoporous
Biosensors. 15.6. Summary. References. INDEX.
Nanotube-Based Sensors and Biosensors (Richard G. Compton, Gregory G.
Wildgoose, and Elicia L. S. Wong). 1.1. Introduction to the Structure of
Carbon Nanotubes. 1.2. Electroanalysis Using CNT-Modified Electrodes. 1.3.
Advantageous Application of CNTs in Sensors: pH Sensing. 1.4. Carbon
Nanotube-Based Biosensors. 1.5. Using CNTs in Biosensor Production for
Medical Diagnostics and Environmental Applications. References. 2.
Isotropic Display of Biomolecules on CNT-Arrayed Nanostructures (Mark R.
Contarino, Gary Withey, and Irwin Chaiken). 2.1. Introduction: CNT Arrays
for Biosensing. 2.2. Functionalization of CNTs: Controlling Display Through
Covalent Attachment. 2.3. Self-Assembling Interfaces: Anchor-Probe
Approach. 2.4. Molecular Wiring of Redox Enzymes. 2.5. Multiplexing
Biomolecules on Nanoscale CNT Arrays. 2.6. Conclusions. References. 3.
Interaction of DNA with CNTs: Properties and Prospects for Electronic
Sequencing (Sheng Meng and Efthimios Kaxiras). 3.1. Introduction. 3.2.
Structural Properties of Combined DNA-CNT Systems. 3.3. Electronic
Structure. 3.4. Optical Properties. 3.5. Biosensing and Sequencing of DNA
Using CNTs. 3.6. Summary. References. PART II NANOPARTICLES. 4. Improved
Electrochemistry of Biomolecules Using Nanomaterials (Jianxiu Wang, Andrew
J. Wain, Xu Zhu, and Feimeng Zhou). 4.1. Introduction. 4.2. CNT-Based
Electrochemical Biosensors. 4.3. Nanoparticle-Based Electrochemical
Biosensors. 4.4. Quantum Dot-Based Electrochemical Biosensors. 4.5.
Conclusions and Outlook. References. 5. The Metal Nanoparticle Plasmon Band
as a Powerful Tool for Chemo- and Biosensing (Audrey Moores and Pascal Le
Floch). 5.1. Introduction. 5.2. The SPB: An Optical Property of Metal NPs.
5.3. Plasmon Band Variation Upon Aggregation of Nanoparticles. 5.4. Plasmon
Band Variation on the Environment or Ligand Alteration. 5.5. Metal
Nanoparticles as Labels. 5.6. Conclusions. References. 6. Gold
Nanoparticles: A Versatile Label for Affinity Electrochemical Biosensors
(Adriano Ambrosi, Alfredo de la Escosura-MunÜ iz, Maria Teresa Castaneda,
and Arben Merkoci). 6.1. Introduction. 6.2. Synthesis of AuNPs. 6.3.
Characterization of AuNPs. 6.4. AuNPs as Detecting Labels for Affinity
Biosensors. 6.5. Conclusions. References. 7. Quantum Dots for the
Development of Optical Biosensors Based on Fluorescence (W. Russ Algar and
Ulrich J. Krull). 7.1. Introduction. 7.2. Quantum Dots. 7.3. Basic
Photophysics and Quantum Confinement. 7.4. Quantum Dot Surface Chemistry
and Bioconjugation. 7.5. Bioanalytical Applications of Quantum Dots as
Fluorescent Labels. 7.6. Fluorescence Resonance Energy Transfer and Quantum
Dot Biosensing. 7.7. Summary. References. 8. Nanoparticle-Based Delivery
and Biosensing Systems: An Example (Almudena MunÜoz Javier, Pablo del Pino,
Stefan Kudera, and Wolfgang J. Parak). 8.1. Introduction. 8.2. Functional
Colloidal Nanoparticles. 8.3. Polyelectrolyte Capsules as a Functional
Carrier System. 8.4. Uptake of Capsules by Cells. 8.5. Delivery and Sensing
with Polyelectrolyte Capsules. 8.6. Conclusions. References. 9. Luminescent
Quantum Dot FRET-Based Probes in Cellular and Biological Assays (Lifang
Shi, Nitsa Rosenzweig, and Zeev Rosenzweig). 9.1. Introduction. 9.2.
Luminescent Quantum Dots. 9.3. Fluorescence Resonance Energy Transfer. 9.4.
Quantum Dot FRET-Based Protease Probes. 9.5. Summary and Conclusions.
References. 10. Quantum Dot-Polymer Bead Composites for Biological Sensing
Applications (Jonathan M. Behrendt and Andrew J. Sutherland). 10.1.
Introduction. 10.2. Quantum Dot-Composite Construction. 10.3. Applications
of QD Composites. 10.4. Future Directions. References. 11. Quantum Dot
Applications in Biomolecule Assays (Ying Xu, Pingang He, and Yuzhi Fang).
11.1. Introduction to QDs and Their Applications. 11.2. Preparation of QDs
for Conjugation with Biomolecules and Cells. 11.3. Special Optoelectronic
Properties in the Bioemployment of QDs. 11.4. Employment of QDs as
Biosensing Indicators. References. 12. Nanoparticles and Inductively
Coupled Plasma Mass Spectroscopy-Based Biosensing (Arben Merkoc¿i, Roza
Allabashi, and Alfredo de la Escosura-Muniz). 12.1. ICP-MS and Application
Possibilities. 12.2. Detection of Metal Ions. 12.3. Detection of
Nanoparticles. 12.4. Analysis of Metal-Containing Biomolecules. 12.5.
Bioanalysis Based on Labeling with Metal Nanoparticles. 12.6. Conclusions.
References. PART III NANOSTRUCTURED SURFACES. 13. Integration Between
Template-Based Nanostructured Surfaces and Biosensors (Walter Vastarella,
Jan Maly, Mihaela Ilie, and Roberto Pilloton). 13.1. Introduction. 13.2.
Nanosphere Lithography. 13.3. Nanoelectrodes Ensemble for Biosensing
Devices. 13.4. Concluding Remarks. References. 14. Nanostructured Affinity
Surfaces for MALDI-TOF-MS-Based Protein Profiling and Biomarker Discovery
(R. M. Vallant, M. Rainer, M. Najam-Ul-Haq, R. Bakry, C. Petter, N. Heigl,
G. K. Bonn, and C. W. Huck). 14.1. Proteomics and Biomarkers. 14.2. MALDI
in Theory and Practice. 14.3. Carbon Nanomaterials. 14.4. Near-Infrared
Diffuse Reflection Spectroscopy of Carbon Nanomaterials. References. PART
IV NANOPORES. 15. Biosensing with Nanopores (Ivan Vlassiouk and Sergei
Smirnov). 15.1. Nanoporous Materials in Sensing. 15.2. Nanochannel and
Nanopore Fabrication. 15.3. Surface Modification Chemistry 15.4.
Nonelectrical Nanoporous Biosensors. 15.5. Electrical Nanoporous
Biosensors. 15.6. Summary. References. INDEX.