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This sequal to the "Pocket Guide to Biotechnology and Genetic Engineering", now in a large format, is ideal for exam preparations as well as serving as a handy reference for professionals, offering a concise and readily understandable overview of all important topics in modern biotechnology and genetic engineering. The content has been completely updated and restructured to reflect recent trends and developments and to follow the teaching curricula of most academic courses. New entries include glycobiology, algae, epigenetics, pre- and probiotics as well as C-sources and synthetic biology. The…mehr
This sequal to the "Pocket Guide to Biotechnology and Genetic Engineering", now in a large format, is ideal for exam preparations as well as serving as a handy reference for professionals, offering a concise and readily understandable overview of all important topics in modern biotechnology and genetic engineering. The content has been completely updated and restructured to reflect recent trends and developments and to follow the teaching curricula of most academic courses. New entries include glycobiology, algae, epigenetics, pre- and probiotics as well as C-sources and synthetic biology. The textbook still contains entries on the key topics in fermentation, bioprocess engineering and enzyme technology, along with industrial applications of biotechnology, focusing on the fields of food and medicine. The basic terms of microbiology, biochemistry, genetic engineering and cell biology are explained via an attractive layout including full color plates and the corresponding explanatory text. The whole is rounded off by a section on agricultural and environmental topics, as well as safety and ethical aspects. The result is the number-one primer in biotechnology.
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Autorenporträt
Rolf Schmid studied chemistry, biochemistry and microbiology in Munich and Freiburg (Germany). After postdoctoral training in Gif-sur-Yvette (France) and Austin (USA), he joined Henkel KGaA in Dusseldorf (Germany) where he worked for 15 years, eventually as Director R&D Biotechnology. In 1987, he was invited to direct the Institute for Enzyme Technology at Braunschweig Technical University and the Division of Enzyme Technology and Chemistry of Natural Products at the 'Gesellschaft für biotechnologische Forschung' (GBF) in Braunschweig (Germany). From 1993 to 2009, he was Director of the Institute for Enzyme Technology at Stuttgart University (Germany). After having obtained an MBA diploma from the University of Reutlingen in 2007, he founded the consulting agency www.bio4business.eu in Stuttgart, followed in 2015 by the Steinbeis Consulting Agency www.asia-tech.eu. Dr. Claudia Schmidt-Dannert is Distinguished McKnight Professor in the Department of Biochemistry, Molecular Biology and Biophysics, at the University of Minnesota (USA). She studied Biology and Biochemistry at the Carolo Wilhelmina University Braunschweig (Germany), where she received her Ph.D. in Biochemistry in 1994. Schmidt-Dannert held a Postdoc position in Molecular Biotechnology at the University of Stuttgart (Germany) and became Professor at the University of Minnesota in 2010. Her research focuses on exploring and utilizing the metabolic machineries of plants and microorganisms to enable the discovery and synthesis of valuable microbial or plant-derived compounds in engineered microbial cells.
Inhaltsangabe
INTRODUCTION Early developments Biotechnology today MICROBIOLOGICAL FUNDAMENTALS Viruses Bakteriophags Microorganisms Bacteria Bacteria: charakterization Fungi Yeasts Microorganisms: isolation, stem maintenance, safety Stem maintenance of microorganisms FUNDAMENTALS OF BIOPROCESS ENGINEERING Culture growth kinetics and product formation fed-batch and continuous fermentations Fermentation technique Fermentation technique: upscaling Cultivation of animal cells Cultivation of animal cells: technical concepts Enzyme and cell reactors Downstream processing of bioproducts Downstream processing of bioproducts: chromatography Industrial processes MOLECULAR GENETIC METHODS DNA: structure DNA: Function Gene technology: general working steps Preparation of DNA, restriction enzymes Enzymes fortreatment of DNA PCR - general method and applications PCR DNA: synthesis and size determination - application examples DNA: sequencing Introduction of DNA in living cells (transformation) Cloning and identificationof genes Gene expression Silencing of genes Protein design Gen banks and gene mapping Genomes of prokaryotes Genomes of eukaryotes Human genome Functional analysis of the human genome DNA analytics DNA arrays Reporter groups Gene therapy High-throughput genome sequencing Comparative genomics Pharmacogenomics Metagenomics Metabolomics and metabonomics Glycobiology Structural biology Biorefineries RNA technology Stem cell technology Tissue Engineering ALCOHOLS, ACIDS AND AMINO ACIDS Ethanol 1-Butanol, acetone Acetic acid Citric acid Lactic acid and gluconic acid Amino acids L-Glutamic acid D,L-Methionine, L-lysine, L-threonine L-Phenylalanine and L-aspartic acid, Apartame? Amino acids by enzymatic transformation ANTIBIOTICS Antibiotics: abundance, applications and mechanisms of action Antibiotics: production and resistance Lactam antibiotics: structure, biosynthesis and mechanism of action Lactam antibiotics: production Amino acid and peptide antibiotics Glycopeptide, polyether and nucleoside antibiotics Amino glycoside antibiotics Chinones, chinolones and aromatic antibiotics Polyketide antibiotics New strategies for antibiotics SPECIALTIES Vitamins Nukleosides and nucleotides Biotensides and biocosmetics Polysaccharides (dextran, xanthan) Biomaterials Biotransformation Steroid-biotransformations ENZYMES Enzymes Enzyme catalysis Enzymes for analytics Enzyme analytics Enzymes in technical applications Detergent enzymes Enzymes für starch degradation Enzymatic starch hydrolysis Enzymes and sweetenting Cellulasens and hemicellulases Enzymes for pulp and paper production Pectinases Enzymes for milk treatment Enzymes for treatment of bakery goods and meet Enzymes for leather treatment New startegies for technical enzymes BIOTECHNOLOGY OF FOOD Alkoholic beverages Beer Fermentierted food Food and lactic acid fermentation BAKERS' YEAST AND FODDER YEASTS Bakers' yeast and fodder yeasts Proteins and oil from singel cell organisms BIOTECHNOLOGY AND ENVIRONMENTAL PROTECTION Aerobic wastewater treatment Anaerobic wastewater and slugde treatment Biological off-gas purification Biological soil remediation Microbial ore leaching and biocorrosion THERAPEUTIC AND DIAGNOSTIC BIOTECHNOLOGY Insulin Somatotropin and ohter hormones Hemoglobin, serum albumin, lactoferrin Clotting factors Anticoagulants and thrombolytics Enzyme inhibitors The immune system Stem cells Interferons Interleukins Erythropoietin and growth factors TNF and other pharma proteins Vaccines, recombinant vaccines Antibodies monoclonal antibodies recombinant antibodies Immune analytics Biosensors AGRICULTURAL BIOTECHNOLOGY Animal breeding Embryo transfer, cloned animals Gen mapping Transgenic animals Gene farming Plant breeding Plant cell cultures: surface cultures Plant cell cultures: suspension cultures Transgenic plants: methods Transgenic plants: resistance Transgenic plants as bioreactors CURRENT TRENDS Compund screening Proteomics Bioinformatics Metabolism Metabolic engineering SAFETY, ETHICS, ECONOMY Safety in gene technology Approval of bio- and gene technicologiocal products Ethics and acceptance Patents and biotechnology International comparison
INTRODUCTION Early developments Biotechnology today MICROBIOLOGICAL FUNDAMENTALS Viruses Bakteriophags Microorganisms Bacteria Bacteria: charakterization Fungi Yeasts Microorganisms: isolation, stem maintenance, safety Stem maintenance of microorganisms FUNDAMENTALS OF BIOPROCESS ENGINEERING Culture growth kinetics and product formation fed-batch and continuous fermentations Fermentation technique Fermentation technique: upscaling Cultivation of animal cells Cultivation of animal cells: technical concepts Enzyme and cell reactors Downstream processing of bioproducts Downstream processing of bioproducts: chromatography Industrial processes MOLECULAR GENETIC METHODS DNA: structure DNA: Function Gene technology: general working steps Preparation of DNA, restriction enzymes Enzymes fortreatment of DNA PCR - general method and applications PCR DNA: synthesis and size determination - application examples DNA: sequencing Introduction of DNA in living cells (transformation) Cloning and identificationof genes Gene expression Silencing of genes Protein design Gen banks and gene mapping Genomes of prokaryotes Genomes of eukaryotes Human genome Functional analysis of the human genome DNA analytics DNA arrays Reporter groups Gene therapy High-throughput genome sequencing Comparative genomics Pharmacogenomics Metagenomics Metabolomics and metabonomics Glycobiology Structural biology Biorefineries RNA technology Stem cell technology Tissue Engineering ALCOHOLS, ACIDS AND AMINO ACIDS Ethanol 1-Butanol, acetone Acetic acid Citric acid Lactic acid and gluconic acid Amino acids L-Glutamic acid D,L-Methionine, L-lysine, L-threonine L-Phenylalanine and L-aspartic acid, Apartame? Amino acids by enzymatic transformation ANTIBIOTICS Antibiotics: abundance, applications and mechanisms of action Antibiotics: production and resistance Lactam antibiotics: structure, biosynthesis and mechanism of action Lactam antibiotics: production Amino acid and peptide antibiotics Glycopeptide, polyether and nucleoside antibiotics Amino glycoside antibiotics Chinones, chinolones and aromatic antibiotics Polyketide antibiotics New strategies for antibiotics SPECIALTIES Vitamins Nukleosides and nucleotides Biotensides and biocosmetics Polysaccharides (dextran, xanthan) Biomaterials Biotransformation Steroid-biotransformations ENZYMES Enzymes Enzyme catalysis Enzymes for analytics Enzyme analytics Enzymes in technical applications Detergent enzymes Enzymes für starch degradation Enzymatic starch hydrolysis Enzymes and sweetenting Cellulasens and hemicellulases Enzymes for pulp and paper production Pectinases Enzymes for milk treatment Enzymes for treatment of bakery goods and meet Enzymes for leather treatment New startegies for technical enzymes BIOTECHNOLOGY OF FOOD Alkoholic beverages Beer Fermentierted food Food and lactic acid fermentation BAKERS' YEAST AND FODDER YEASTS Bakers' yeast and fodder yeasts Proteins and oil from singel cell organisms BIOTECHNOLOGY AND ENVIRONMENTAL PROTECTION Aerobic wastewater treatment Anaerobic wastewater and slugde treatment Biological off-gas purification Biological soil remediation Microbial ore leaching and biocorrosion THERAPEUTIC AND DIAGNOSTIC BIOTECHNOLOGY Insulin Somatotropin and ohter hormones Hemoglobin, serum albumin, lactoferrin Clotting factors Anticoagulants and thrombolytics Enzyme inhibitors The immune system Stem cells Interferons Interleukins Erythropoietin and growth factors TNF and other pharma proteins Vaccines, recombinant vaccines Antibodies monoclonal antibodies recombinant antibodies Immune analytics Biosensors AGRICULTURAL BIOTECHNOLOGY Animal breeding Embryo transfer, cloned animals Gen mapping Transgenic animals Gene farming Plant breeding Plant cell cultures: surface cultures Plant cell cultures: suspension cultures Transgenic plants: methods Transgenic plants: resistance Transgenic plants as bioreactors CURRENT TRENDS Compund screening Proteomics Bioinformatics Metabolism Metabolic engineering SAFETY, ETHICS, ECONOMY Safety in gene technology Approval of bio- and gene technicologiocal products Ethics and acceptance Patents and biotechnology International comparison
Rezensionen
"...you should have it close at hand on your desktop as you read new articles. I would recommend this reference book...not only to clinical chemists, pathalogists, and medical technologists, but to anyone in medicine who wants to know how all the new therapeutic agents are made and appriciates the impact of biotechnology an medicine and society." Clinical Chemistry
"...this book is a useful, interesting and colourful guide to modern biotechnology and genetic engineering. It will achieve its objective of providing students with an overview of the field presented in manageable portions and a clear and accessible manner, but it will also be a source of information, a useful reference and an interesting read for any researcher who is working across the traditional boundaries of chemistry, biology or biochemistry." ChemBioChem
"This pocket guide can be recommended unreservedly for all students and researchers in natural and engineering sciences and medicine, but is also useful to readers with a general interest in biotechnology and genetic engineering. I can certainly agree with the final sentence of the book cover: A perfect introduction to the field - for professionals and students." Angewandte Chemie IE
Erwähnung in: Process "...provides a broad coverage of the relevant facts on products, methods and applications in biotechnology and genetic engineering...Instructive yet attractive color illustrations and a didactic approach throughout the book..." Process worldwide
"Beginners and experts will like this wonderfully composed book." Journal of Statistical Computation & Simulation
"In the wilderness of biotechnology, Schmid's "Pocket Guide to Biotechnology and Genetic Engineering" is a welcome addition that with all likelihood will find many friends. During the review process it has definitely found one! The book is excellently produced. The figures are as sharp as tacks and as informative as the text...The overall verdict is: useful and recommendable to students and biotechnologists alike." Engineering in Life Sciences…mehr
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