Alberto Espay, Benjamin Stecher

Brain Fables (eBook, PDF)

The Hidden History of Neurodegenerative Diseases and a Blueprint to Conquer Them

• Format: PDF

Produktbeschreibung

With no biological boundaries between neurodegenerative diseases as defined today, Brain Fables offers a blueprint for precision medicine.

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Produktdetails

• Verlag: Cambridge University Press
• Erscheinungstermin: 9. Juli 2020
• Englisch
• ISBN-13: 9781108899765
• Artikelnr.: 70908602

Autorenporträt

Alberto Espay is Professor of Neurology and Endowed Chair of the University of Cincinnati James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders. He has published extensively on Parkinson's disease and leads the first phenotype-agnostic biomarker development program for patients with neurodegenerative diseases (CCBP) designed to deploy bioassays aiming at matching available therapies with those most likely to benefit, regardless of their clinical diagnosis.

Inhaltsangabe

Preface
Acknowledgements
1. The shaky six and the 'second reality'
2. Pieces of a puzzle?
3. Disease 'redefinition': a tough pill to swallow
4. Disease subtypes: the promise and the fallacy
5. Protein paradox
6. The fault in our models
7. Biomarkers: the promise and the fallacy
8. Lessons from oncology
9. Symptomatic vs. disease-modifying therapies
10. The hypothesis that refuses to die
11. Our living dissonance
12. The scientific and lay narratives
13. Challenges viewed from afar
14. The moonshot: population-based studies of aging
15. Predictions for the 2020s and beyond
Epilogue. 'When will we have a cure for Parkinson's disease?"
Note added at press time
References
Index.