Brain Norepinephrine (eBook, PDF)

Neurobiology and Therapeutics
Redaktion: Ordway, Gregory A.

• Format: PDF

Produktbeschreibung

Norepinephrine is a chemical neurotransmitter. Drugs that directly manipulate central nervous system (CNS) norepinephrine are being developed targeting noradrenergic neurons to deliver therapeutic effects. Noradrenergic drugs have been proven effective for depression and ADHD, and new disease indications are being identified. A team of experts provides the reader with a thorough understanding of the anatomy, physiology, molecular biology, pharmacology and therapeutics of norepinephrine in the brain, including an extensive review of the role of norepinephrine in brain diseases. The book is divided into four sections: the basic biology of norepinephrine; the role that norepinephrine plays in behavior; evidence of norepinephrine's role in CNS diseases, and the pharmacology and therapeutics of noradrenergic drugs in the treatment of psychiatric and neurological disorders.

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Produktdetails

• Verlag: Cambridge University Press
• Erscheinungstermin: 15. Februar 2007
• Englisch
• ISBN-13: 9780511271120
• Artikelnr.: 38216057

Autorenporträt

Dr Ordway is Chair of the Department of Pharmacology at the James H. Quillen College of Medicine at East Tennessee State University.
Dr Schwartz is Clinical Professor of Psychiatry at the University of Hawaii. He is also Adjunct Professor of Philosophy and Adjunct Professor of Psychiatry at the University of Louisville in Louisville, Kentucky, and serves as Medical Director of the Irwin Foundation in Austin, Texas.
Dr Alan Frazer is Chair of the Department of Pharmacology at The University of Texas Health Science Center at San Antonio. He is also a Professor in the Department of Psychiatry at UTHSCSA and is an adjunct Professor in pharmacology departments at the College of Pharmacy of the University of Texas in Austin, and the School of Medicine of the University of Pennsylvania.

Inhaltsangabe

Introduction: revision of an old transmitter Gregory A. Ordway; Part I. The
Neurobiology of Norepinephrine: 1. Neuroanatomical and chemical
organization of the locus coeruleus Kimberly L. Simpson and Rick C. S. Lin;
2. Interactions of norepinephrine with other neurotransmitter systems:
anatomical basis and pharmacology Craig A. Stockmeier and Gregory A.
Ordway; 3. Receptors for norepinephrine and signal transduction pathways
David B. Bylund; 4. Regulation of gene transcription in the central nervous
system by norepinephrine Ronald S. Duman and Samuel S. Newton; 5. The
norepinephrine transporter and regulation of synaptic transmission Subbu
Apparsundaram; Part II. Norepinephrine and Behavior: 6. Role of the locus
coeruleus-norepinephrine system in arousal and circadian regulation of the
sleep wake cycle Gary S. Aston-Jones, Monica Gonzalez and Scott Doran; 7.
Locus coeruleus and regulation of behavioral flexibility and attention:
clinical implications Gary S. Aston-Jones, Michiyo Iba, Edwin Clayton,
Janusz Rajkowski and Jonathan Cohen; 8. Norepinephrine and long-term memory
function Benno Roozendaal; 9. Norepinephrine and stress David A. Morilak;
Part III. The Biology of Norepinephrine in CNS Pathology: 10. Animal models
of psychopathology: focus on norepinephrine Leonie A. M. Welberg and Paul
Plotsky; 11. Neuropathology of central norepinephrine in psychiatric
disorders: postmortem research Gregory A. Ordway; 12. Norepinephrine in
mood disorders Pedro L. Delgado and Cristinel Coconcea; 13. Noradrenergic
pathology and pain Antti Pertovaara; 14. Norepinephrine in cognitive
disorders Amy F. T. Arnsten; 15. Norepinephrine in neurological disorders
Francesco Fornai; 16. Genetics of noradrenergic neurobiology Inna Belfer
and David Goldman; Part IV. Psychopharmacology of Norepinephrine: 17.
Actions of antidepressant and other drugs on norepinephrine systems Elliott
Richelson; 18. The clinical role of norepinephrine antidepressants in
depression and anxiety disorders J. Craig Nelson; 19. Norepinephrine in
attention deficit hyperactivity disorder Fred W. Riemherr, Michael A.
Schwartz, B. K. Marchant and E. Higgins; 20. Psychopharmacology of
norepinephrine in eating disorders Katherine A. Halmi and Sun Young Yum;
21. Role of norepinephrine in substance abuse Susan L. Broom and Bryan K.
Yamamoto.