Brain Protection in Cardiac Surgery (eBook, PDF)

Redaktion: Bonser, Robert S.; Haverich, Axel; Pagano, Domenico

• Format: PDF

Produktbeschreibung

Brain injury remains one of the most dreaded complications of cardiac surgery. The range of injury is broad; while a stroke may be easily defined and diagnosed, more subtle injuries most definitely occur. There remains debate as to how these are diagnosed and there is a lack of standard definitions allowing inter-study comparison. If we are to have confidence in strategies that may reduce brain injury, we need to have confidence in the end-points used to define that injury. We need to better understand the phenomena associated with neuropsychometric testing; we need to fully elucidate the relationship between structural brain injury, embolism counting, and surrogate biomarkers; and we need an improved understanding of the clinical significance of abnormalities detected on postoperative magnetic resonance imaging. Brain Protection in Cardiac Surgery presents a detailed background of studies of neurological morbidity and neuroprotection from a range of experts in the field of neuroprotection, providing a detailed reference for clinicians in the field. The Editors have detailed connections between the different strands of injury - be it the pathology, the imaging, the clinical and cognitive examination, potential biomarkers - and have then provided summary reports of treatment strategies that may reduce such injury. As we look to the future, the design of studies attempting to reduce such injury becomes increasingly important and this book provides the fundamental background information to fuel interest, initiate novel prevention and therapeutic strategies, and inform the investigator how to develop and design their research study.

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Produktdetails

• Verlag: Springer London
• Seitenzahl: 246
• Erscheinungstermin: 15. Dezember 2010
• Englisch
• ISBN-13: 9781849962933
• Artikelnr.: 37351496

Inhaltsangabe

Brain injury of cardiac surgery.-Cerebral physiology & metabolism.-Molecular & biochemical basis.Future interventions.-Cardiopulmonary bypass circuit.-Neurological sequelae.-Incidence, pre-operative risk factors & long-term outcome.-Neuropathology.-Inflammatory response.-Post-surgical impact.-Assessment of brain injury.-Utility of neuropsychometric analysis.-Pitfalls of neuropsychometric assessment & alternative investigative approaches.-Imaging of the brain.-Current techniques of emboli detection.-Intra-operative brain monitoring.-Design of brain protection studies in the C21st.-Reducing brain injury in cardiac surgery.-Temperature & brain protection.-Studies of non-pharmacological interventions.-Pharmacological studies to reduce brain injury following cardiac surgery.-Off-pump & on-pump coronary artery surgery & the brain.-Experimental basis & clinical studies of brain protection in paediatric heart surgery.-Experimental basis & clinical studies of brain protection in aortic arch surgery.-The future.

Rezensionen

From the reviews:
"This book addresses the current understanding of the neurocognitive issues associated with the surgery. ... is directed at healthcare professionals specializing in cardiac surgery - practicing surgeons and anesthesiologists, residents and fellows, intensive care physicians, neurologists and neurointensivists, researchers and other practitioners. ... Select tables, graphs, illustrations, and imaging studies support the information. ... a unique synopsis of the state of knowledge on this subject. It is an invaluable educational resource for a wide range of professionals whose careers are related to cardiac surgery." (Zdravka Zafirova, Doody's Review Service, December, 2011)