Théophile Godfraind

Calcium Channel Blockers (eBook, PDF)

• Format: PDF

Produktbeschreibung

The main effect of calcium channel blockers is the blockade of calcium entry into cells through voltage operated calcium channels. This volume gives a comprehensive overview of the different classes of CCBs and their various effects. It covers historical development, pharmacology, clinical aspects, and perspectives. All chapters are written by Prof. T. Godfraind, a world leading expert in the field.

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Produktdetails

• Verlag: Springer Basel
• Seitenzahl: 262
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9783034878593
• Artikelnr.: 53205965

Inhaltsangabe

Historical perspective: from early steps on calcium research to the identification of calcium antagonist prototypes and of the signaling functions of Ca2+.- Calcium channel blockers and calcium channels.- The action of calcium antagonists on Ca2+ movements in isolated vessels.- The tissue selectivity of calcium antagonists.- Acute haemodynamic effects of calcium channel blockers.- Calcium channels and regulation of vascular tone in hypertension.- Long-term effects of calcium antagonists.- Blood pressure-independent effects of calcium antagonists.- From early clinical studies to randomized controlled clinical trials.- Beyond the cardiovascular system.