Calcium: The molecular basis of calcium action in biology and medicine (eBook, PDF)

Redaktion: Pochet, R.; Gerke, Volker; Heizmann, Claus W.; Haiech, J.; Donato, Rosario

• Format: PDF

Produktbeschreibung

The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world. The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era. The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets. In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches. Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists. The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.

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Produktdetails

• Verlag: Springer Netherlands
• Seitenzahl: 732
• Erscheinungstermin: 28. Juni 2011
• Englisch
• ISBN-13: 9789401006880
• Artikelnr.: 43983770

Inhaltsangabe

From Genes to Drugs.- Ca2+ Release in Muscle Cells.- Calcium Signalling in Neurons Exemplified by Rat Sympathetic Ganglion Cells.- Calcium and Platelets.- Calcium Signalling in Liver Cells.- Intercellular Calcium Signalling in "Non-Excitable" Cells.- The Ca2+-Mobilizing Second Messenger Cyclic ADP-Ribose.- Visinin-Like Proteins (VILIPs) - Emerging Role in Cross-Talk between Cellular Signaling Pathways.- Calcium Binding to Extracellular Matrix Proteins, Functional and Pathological Effects.- The Extracellular Calcium-Sensing Receptor: Molecular Features, Distribution and Its Roles in Physiology and Disease.- Regulation of Inositol 1,4,5-Triphosphate-Induced Ca2+ Release by Ca2+.- Calreticulin and Dynamics of the Endoplasmic Reticulum Lumenal Environment.- Ryanodine-Sensitive Calcium Release Channels.- Calcium Inhibition of Cytoplasmic Streaming.- Penta-EF-Hand (PEF) Proteins and Calsenilin/DREAM: Involvement of the New EF-Hand Calcium-Binding Proteins in Apoptosis and Signal Transduction.- Activation of Programmed Cell Death by Calcium: Protection against Cell Death by the Calcium Binding Protein, Calbindin-D28k.- Calcium and Cellular Ageing.- The Epidermal Growth Factor Receptor and the Calcium Signal.- Annexinopathies.- Autoimmune Disease and Calcium Binding Proteins.- Calcium Antagonists and Calcium Sensitizers.- Calcium-Binding Proteins in Type I Allergy: Elicitors and Vaccines.- Calcium Channelopathies in Nervous System.- Calcium and Diabetes.- Inherited and Acquired Disorders of Extracellular Calcium (Ca02+)-Sensing.- Calcium and Muscle Disease: Pathophysiology of Calpains and Limb-Girdle Muscular Distrophy Type 2a (LGMD2A).- Role of Calcium Channels in Drug Dependence.- S100 Proteins and Fatty Acid Transport Are Altered in Skin Diseases.- Calcium-BindingProteins in Degenerative and Cancer-Related Diseases of the Eye.- Calcium ATPases Genes and Cell Transformation.- Interaction of Dimeric S100B (??) with the Tumor Suppressor Protein p53: A Model for Ca2+-Dependent S100-Target Protein Interactions.- The Interaction of Calmodulin with Novel Target Proteins.- Type II Citrullinemia (Citrin Deficiency): A Mysterious Disease Caused by a Defect of Calcium-Binding Mitochondrial Carrier Protein.- High Calcium Concentrations, Calpain Activation and Cytoskeleton Remodeling in Neuronal Regeneration after Axotomy.- Genetic Factors and the Role of Calcium in Alzheimer's Disease Pathogenesis.- The Role of Intracellular Calcium Signaling in Motoneuron Function and Disease.- Pharmaceutical Chemistry and Drug Screening.- Calcium in Drug Screening.- Imaging Intracellular Calcium in Living Tissue by Laser-Scanning Confocal Microscopy.- Immature Mouse Oocyte as a Model for Imaging Nuclear Calcium Dynamics.- Single Cell Fluorescence Imaging to Investigate Signaling in Primary Cultured Neurones.- Calcium Complexities: New Fluorescence Techniques for Probing Mitochondria and Other Subcellular Compartments.