Cancer and Autoimmunity (eBook, PDF)

Redaktion: Gershwin, M. E.; Shoenfeld, Yehuda

• Format: PDF

Produktbeschreibung

Of the two disciplines in parallel development for two decades, tumor immunology and transplantation immunology, the latter has thrived and has led to some of the most critical discoveries in immunobiology. The former continues to thwart both scientists and clinicians alike.
The goal of immunologists in modern day research is to develop a simple and effective means to manipulate cancer in vivo, possibly encompassing several venues: identifying a phenotypic marker and the use of either active or passive immunization; include the use of passive reagents carrying "warheads" to selectively destroy cancer cells; or altering the basic process of cell survival.
This excellent multidiscipline-authored volume presents a theme which has not been well described before. The papers include both basic and clinical science and range from sophisticated molecular biology to little more than phenomenology (e.g. the increased association of cancer in some autoimmune diseases and increased presentation of autoimmune phenomena in malignant condition). This, however, is state-of-the-art.
This collection of themes will be of use not only to bench scientists, but also to clinicians who treat patients. The book represents progress at the cutting edge of this discipline, and points the way to further developments in the "black box" of immunology.

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 468
• Erscheinungstermin: 27. März 2000
• Englisch
• ISBN-13: 9780080528458
• Artikelnr.: 38120227

Inhaltsangabe

Preface. List of Contributors. Introduction: The Immune System
the Autoimmune State and Autoimmune Disease (Jacob George
Yehuda Shoenfeld). Chapter I: Malignancies in Autoimmune Diseases. 1. Rheumatoid Arthritis and Cancer (Mahmoud Abu-Shakra
Dan Buskila
Yehuda Shoenfeld). 2. SLE and Cancer (Mahmoud Abu-Shakra
Dan Buskila
Yehuda Shoenfeld). 3. Malignancies Occurring in Scleroderma (Pascal Godmer
Loïc Guillevin). 4. PSS (Scleroderma) and Cancer (Anabel Aron-Maor
Yehuda Shoenfeld). 5. Vasculitis and Malignancy (Efstratios Tatsis
Wolfgang L. Gross). 6. Sjögren's Syndrome and Lymphoproliferative Disease (Manel Ramos-Casals
Mario García-Carrasco
Josep Font
Richard Cervera). 7. Polymyalgia Rheumatica
Temporal Arthritis and Occurrence of Malignant Tumors (Jozef Rovenský
Alena Tuchyňová). 8. Myositis and Neoplasia (Claire Fieschi
Jean-Charles Piette). 9. Antiphospholipid Antibodies and Malignancies (Ronald A. Asherson
R. Cervera). 10. Malignancy in Coeliac Disease and Dermatitis Herpetiformis (Helena Tlaskalová
Ludmila Tučková
Miloslav Pospišil
Renata Štěpánková). 11. Autoimmune Rheumatic Diseases and Cancer: Evidence of Causality? (Antonio R. Villa
Arnoldo Kraus
Donato Alarcón-Segovia). Chapter II: Autoimmunity in Malignant States. 1. Paraneoplastic Syndromes (Moshe Tishler
Yehuda Shoenfeld). 2. Paraneoplastic Arthritis (S. Praprotnik
M. Tomšič). 3. Autoantibodies
Autoimmunity and Cancer (Yaron Tomer
Yehuda Shoenfeld). 4. Autonuclear Antibodies as Potential Markers of Lung Cancer (F. Fernàndez-Madrid
J. Tomkiel). 5. Autoantibodies in Cancer Patients and in Persons with a Higher Risk of Cancer Development (Karsten Conrad). 6. Autoantibodies to the Proliferation-Associated Nuclear Protein CENP-F in Cancer (Carlos Casiano). 7. p53 Autoantibodies and Cancer: Specificity
Diagnosis and Monitoring (H.T. Flammann
H.-M. Kuhn). 8. Humoral Immune Response Against the Growth Suppressor p53 in Human Malignancies (Mathias Montenarh). 9. Expression of ETS Family of Genes in Systemic Lupus Erythematosis (Panagiotis Georgiou
Ioanna Maroulakou
Narayan K. Bhat
Dennis K. Watson
Takis S. Papas). 10. Immune Response to Tumor Stress Proteins-Implications for Vaccine Development Against Cancer (Michael Heike
Karl-Hermann Meyer zum Büschenfelde). 11. Autoimmunity and B-Cell Malignancies (O. Pritsch
G. Dighiero). 12. Autoimmunity in B-Lymphoproliferative Disorders (Viggo Jonsson
Allan Wiik). 13. CD5 Positive B Cells: Crossroads of Autoimmunity and Lymphoid Malignancy (C. Jamin
J.O. Pers
P.M. Lydyard
P. Youinou). 14. Thymoma and Autoimmune Diseases (Yaniv Sherer
Yehuda Shoenfeld). 15. Castleman's Disease and Autoimmunity (C. Alessandri
F. Viganego
G. Valesini). Chapter III: Mechanisms in Cancer and Autoimmunity. 1. IgA and Cancer (Thomas P. Prindiville
Mary C. Cantrell
Yehuda Shoenfeld
M. Eric Gershwin). 2. Apoptosis: The Relation Between Anti-Fas Antibodies
and Immunosurveillance Against Cancer and Autoimmunity (Yaron Bar-Dayan
Sooryanarayana
Emmanuelle Bonnin
Nagendra Prasad
Yosefa Bar-Dayan
Michel D. Kazatchkine
Srinivas V. Kaveri). 3. Hepatitis C Virus
Autoimmunity and Cancer (Dan Buskila
Emanuel Sikuler
Yehuda Shoenfeld). 4. The Human Neurotropic Virus
JCV
and Its Association with CNS Tumors (Kamel Khalili
Luis Del Valle
Barbara Krynska
Jennifer Gordon
Jessica Otte
Sidney Croul). 5. The Smoking Cancer-Autoimmunity Connection (Jacob George
Yehuda Shoenfeld). 6. Significance and Regulation of the Expression of MHC Class II Molecules on Autoimmune and Neoplastic Thyroid Cells (Nitza Lahat
Ariel Miller
Michal A. Rahat). 7. Cancer Immunity: A Problem of Self-Tolerance (Shohei Hori
Jocelyne Demengeot
Antonio Bandeira
Antonio Coutinho). 8. Maternal Immune Response to Trophoblast
GTD
and Cancer (Eytan R. Barnea
Steven P. Levine). Chapter IV: Therapy in Autoimmunity and Cancer - Common and Different Denominators. 1. Therapy of Cancer and Autoimmunity: Immuno-modulatory Strategies Based on Modified Dendritic Cells (Marc Schmitz
Ernst Peter Rieber). 2. Anti-Idiotypic Therapy in Autoimmunity (Dan Buskila
Mahmoud Abu-Shakra
Yehuda Shoenfeld). 3. Active Specific Immunotherapy of Malignant Diseases - Breaking Tolerance to Self-Antigens with Tumor Associated Antigen Mimics (Elyvra J. Noronha
Xinhui Wang
Smruti A. Desai
Dongsheng Zhang
Joerg Willers
Soldano Ferrone). 4. Antigen-Specific Antitumor Vaccination: Immunotherapy Versus Autoimmunity (Lee Eisenbach
Khaled M. El-Shami). 5. Bone-marrow Transplantation for Cancer and Autoimmunity (Shimon Slavin
Arnon Nagler). 6. Post-chemotherapy Rheumatism (David D'Cruz). 7. Cyclosporin and Cancer (Roberta Priori
Fabrizio Conti
Guido Valesini).