Cancer and Noncoding RNAs (eBook, ePUB)

Redaktion: Chakrabarti, Jayprokas; Mitra, Sanga

• Format: ePub

Produktbeschreibung

Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches.

This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies.

• Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics
• Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis
• Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies
• Features contributions by leading experts in the field

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 576
• Erscheinungstermin: 13. Oktober 2017
• Englisch
• ISBN-13: 9780128134375
• Artikelnr.: 49375071

Inhaltsangabe

1. Introduction
SECTION I: NON-CODING RNAs: FINE-TUNING CANCER 2. miRNA and Cancer: A
Deadly Liaison? 3. Alteration of MicroRNA Biogenesis Pathways in Cancers 4.
MicroRNAs In Exosomes in Cancer 5. Circulating miRNAs Incresaing the Risk
of Cancer 6.  Long Noncoding RNAs as Cancer Biomarkers 7. The Balancing
Act: Understanding MicroRNA and Competing Endogenous RNA Regulation in
Cancer 8. PIWI-Interacting RNAs (piRNAs) and Cancer 9. Transfer RNA in
Cancer 10. Dynamic Regulation of tRNA Modifications in Cancer 11. Circular
RNA: A Novel Noncoding RNA in Cancer 12. Antisense RNA and Cancer 13.
Implication of Other Noncoding RNAs in Cancer
SECTION 2: GENETIC DYSREGULATION OF NON-CODING RNA IN CANCER 14. Noncoding
RNA Alterations in Cancer Molecular Pathways 15. Genetic Alteration of
MicroRNA Affecting Cancer Pathways 16. Genetic Variations of Long Noncoding
RNAs in Cancer
SECTION 3: EPIGENETIC EFFECT ON CANCER THROUGH NON-CODING RNAs 17. Cross
Talk Between Noncoding RNAs and DNA Methylation and Demethylation in Cancer
18. Noncoding RNAs Act as a Chromatin Scaffold of Histone Modification
Complexes in Cancer 19. Heterochromatin Modulation and PcG Control of Gene
Expression Medicated by Noncoding RNA in Cancer 20. Epigenetic Control of
MicroRNA Expression and Cancer 21. Implications of Long Noncoding RNAs in
Cancer Epigenetics
SECTION 4: THERAPEUTIC IMPLICATIONS OF NON-CODING RNA IN CANCER 22. Long
Noncoding RNAs: Insight Into Their Roles in Normal and Cancer Stem Cells
23. Clinical Relevance, Prognostic Potential, and Therapeutic Strategies of
Noncoding RNAs in Cancer 24. Noncoding RNAs: Novel Targets in Anticancer
Drug Development
SECTION 5: BIOINFORMATICS' DETECTION OF NON-CODING RNA IN CANCER 25. Cancer
Noncoding RNA Discovery Through High-Throughput Sequencing 26. Noncoding
RNAs as a Cauce of Cancer: Evidence From Genome-Wide Association Studies
and Reverse Genetics 27. A Comparative Evaluation of Emerging Databases and
Tools for Cancer Noncoding RNAs 28. Future Directions and Challenges
Involved in Cancer Noncoding RNomics