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The ability to measure and monitor cancer biomarkers in “body fluid biopsy” should greatly impact oncologic practice. “ Biomarkers in Proximal Fluids ”, the third of the “ Cancer Biomarkers in Body Fluids ” series details cancer signatures in none or minimally circulating body fluids including saliva, sputum, bronchoalveolar lavage fluid, exhaled breath condensate, nipple aspirate fluid, gastric and pancreatic juice, stool, urine, and prostatic, peritoneal and cerebrospinal fluid. These fluids are enriched with biomarkers, especially those emanating from cells of the proximal…mehr
The ability to measure and monitor cancer biomarkers in “body fluid biopsy” should greatly impact oncologic practice. “Biomarkers in Proximal Fluids”, the third of the “Cancer Biomarkers in Body Fluids”series details cancer signatures in none or minimally circulating body fluids including saliva, sputum, bronchoalveolar lavage fluid, exhaled breath condensate, nipple aspirate fluid, gastric and pancreatic juice, stool, urine, and prostatic, peritoneal and cerebrospinal fluid. These fluids are enriched with biomarkers, especially those emanating from cells of the proximal tissue.
Chapter 1 examines the global burden of cancer and the need for regional efforts at primary prevention, early detection and patient care. Chapters 2-12 address tissue-specific biomarkers in associated body fluids. The tumor interstitial fluid as a microenvironment rich in cancer biomarkers is detailed in chapter 13, while chapter 14 looks at the human body fluid microbiome and its evolving role in cancer. Commercially available assays using proximal fluids are examined at the end of the respective chapters. This book complements its predecessors and is equally useful to oncologists, cancer researchers, clinicians, medical students, nurses, diagnostic laboratory and pharmaceutical industry personnel.
Dr. Gabriel D. Dakubo is an Assistant Professor of Molecular Medicine and Human Anatomy in the Division of Medical Sciences at the Northern Ontario School of Medicine. He received his BSc and MBChB degrees from the University of Ghana, followed by the pursuance of a Postdoctoral research fellowship in Molecular Medicine at the Ottawa Hospital Research Institute, Canada. Dr. Dakubo’s passion is in noninvasive deployment of biomarkers for cancer management. While an expert in mitochondrial genetic alterations in cancer, he also has a keen interest in the inter-genomic communications that occur in the cancer cell, as well as the Slaughter’s concept of field cancerization. Dr. Dakubo is well published, and is a reviewer of a number of esteemed journals, including Clinical Cancer Research.
Inhaltsangabe
1. Melanoma Biomarkers in Exfoliated Cells.- 2. Head and Neck Cancer Biomarkers in Saliva.- 3. Lung Cancer Biomarkers in Lung Fluids.- 4. Breast Cancer Biomarkers in Breast Fluids.- 5. Gastric Cancer Biomarkers in Gastric Fluid.- 6. Colorectal Cancer Biomarkers in Stool.- 7. Hepatobiliary Cancer Biomarkers in Bile.- 8. Pancreatic Cancer Biomarkers in Pancreatic Juice.- 9. Renal Cancer Biomarkers in Urine.- 10. Bladder Cancer Biomarkers in Urine.- 11. Prostate Cancer Biomarkers in Prostatic Fluid.- 12. Testicular Cancer Biomarkers in Seminal Fluid.- 13. Ovarian Cancer Biomarkers in Peritoneal Fluid.- 14. Endometrial Cancer Biomarkers in Menstrual Fluid.- 15. Cervical and Vulvar Cancer Biomarkers in Exfoliated Cells.- 16. Brain Cancer Biomarkers in Cerebrospinal Fluid.- 17. Hematologic Cancer Biomarkers in Blood.- 18. The Body Fluid Microbiome and Cancer.- 19. Biomarkers in Interstitial Fluids of Cancer Cells.
PART ONE: SYNOPSIS OF CANCER BIOMARKERS Chapter 1: An Overview of Cancer Biomarkers Chapter 2: Bodily Fluids and Cancer Biomarkers PART TWO: CANCER BIOMARKERS IN CIRCULATION Chapter 3: Circulating Nonspecific Cancer Nucleic Acids Chapter 4: Circulating Cancer Epigenome Chapter 5: Circulating Cancer Genome Chapter 6: Circulating Cancer Transcriptome Chapter 7: Circulating Cancer Noncoding Transcriptome Chapter 8: Circulating Cancer Peptidome/Proteome Chapter 9: Circulating Cancer Metabolome Chapter 10: Circulating Cancer Mitochondrial Genome Chapter 11: Circulating Cancer Cells and Tumor Stem Cells PART THREE: CANCER BIOMARKERS IN TISSUE-SPECIFIC BODY FLUIDS Chapter 12: Skin Cancer Biomarkers in Exfoliated Skin Cells Chapter 13: Head and Neck Cancer Biomarkers in Saliva and Oral Rinses Chapter 14: Lung Cancer Biomarkers in Sputum, Bronchoalveolar Lavage, and Exhaled Breath Chapter 15: Breast Cancer Biomarkers in Nipple Aspirate Fluid, Ductal Lavage, and Fine Needle Aspirates Chapter 16: Gastric Cancer Biomarkers in Gastric Fluid Chapter 17: Hepatobiliary Cancer Biomarkers in Bile Chapter 18: Pancreatic Cancer Biomarkers in Pancreatic Juice Chapter 19: Colorectal Cancer Biomarkers in Stool Chapter 20: Renal Cancer Biomarkers in Urine Chapter 21: Urinary Bladder Cancer Biomarkers in Urine Chapter 22: Prostate Cancer Biomarkers in Urine and Expressed Prostatic Secretions Chapter 23: Testicular Cancer Biomarkers in Semen Chapter 24: Ovarian Cancer Biomarkers in Blood and Ovarian epithelial brushes/washes Chapter 25: Endometrial Cancer Biomarkers in Menstrual Flow Chapter 26: Endometriosis Biomarkers in Menstrual Flow Chapter 27: Cervical, Vaginal and Vulval Cancer Biomarkers in Secretions or Swaps of Anatomic Sites Chapter 28: Biomarkers of Hematologic Malignancies in Circulating Leukocytes and Bone Marrow Aspirates Chapter 29: Nervous System Cancer Biomarkers in Cerebrospinal Fluid
1. Melanoma Biomarkers in Exfoliated Cells.- 2. Head and Neck Cancer Biomarkers in Saliva.- 3. Lung Cancer Biomarkers in Lung Fluids.- 4. Breast Cancer Biomarkers in Breast Fluids.- 5. Gastric Cancer Biomarkers in Gastric Fluid.- 6. Colorectal Cancer Biomarkers in Stool.- 7. Hepatobiliary Cancer Biomarkers in Bile.- 8. Pancreatic Cancer Biomarkers in Pancreatic Juice.- 9. Renal Cancer Biomarkers in Urine.- 10. Bladder Cancer Biomarkers in Urine.- 11. Prostate Cancer Biomarkers in Prostatic Fluid.- 12. Testicular Cancer Biomarkers in Seminal Fluid.- 13. Ovarian Cancer Biomarkers in Peritoneal Fluid.- 14. Endometrial Cancer Biomarkers in Menstrual Fluid.- 15. Cervical and Vulvar Cancer Biomarkers in Exfoliated Cells.- 16. Brain Cancer Biomarkers in Cerebrospinal Fluid.- 17. Hematologic Cancer Biomarkers in Blood.- 18. The Body Fluid Microbiome and Cancer.- 19. Biomarkers in Interstitial Fluids of Cancer Cells.
PART ONE: SYNOPSIS OF CANCER BIOMARKERS Chapter 1: An Overview of Cancer Biomarkers Chapter 2: Bodily Fluids and Cancer Biomarkers PART TWO: CANCER BIOMARKERS IN CIRCULATION Chapter 3: Circulating Nonspecific Cancer Nucleic Acids Chapter 4: Circulating Cancer Epigenome Chapter 5: Circulating Cancer Genome Chapter 6: Circulating Cancer Transcriptome Chapter 7: Circulating Cancer Noncoding Transcriptome Chapter 8: Circulating Cancer Peptidome/Proteome Chapter 9: Circulating Cancer Metabolome Chapter 10: Circulating Cancer Mitochondrial Genome Chapter 11: Circulating Cancer Cells and Tumor Stem Cells PART THREE: CANCER BIOMARKERS IN TISSUE-SPECIFIC BODY FLUIDS Chapter 12: Skin Cancer Biomarkers in Exfoliated Skin Cells Chapter 13: Head and Neck Cancer Biomarkers in Saliva and Oral Rinses Chapter 14: Lung Cancer Biomarkers in Sputum, Bronchoalveolar Lavage, and Exhaled Breath Chapter 15: Breast Cancer Biomarkers in Nipple Aspirate Fluid, Ductal Lavage, and Fine Needle Aspirates Chapter 16: Gastric Cancer Biomarkers in Gastric Fluid Chapter 17: Hepatobiliary Cancer Biomarkers in Bile Chapter 18: Pancreatic Cancer Biomarkers in Pancreatic Juice Chapter 19: Colorectal Cancer Biomarkers in Stool Chapter 20: Renal Cancer Biomarkers in Urine Chapter 21: Urinary Bladder Cancer Biomarkers in Urine Chapter 22: Prostate Cancer Biomarkers in Urine and Expressed Prostatic Secretions Chapter 23: Testicular Cancer Biomarkers in Semen Chapter 24: Ovarian Cancer Biomarkers in Blood and Ovarian epithelial brushes/washes Chapter 25: Endometrial Cancer Biomarkers in Menstrual Flow Chapter 26: Endometriosis Biomarkers in Menstrual Flow Chapter 27: Cervical, Vaginal and Vulval Cancer Biomarkers in Secretions or Swaps of Anatomic Sites Chapter 28: Biomarkers of Hematologic Malignancies in Circulating Leukocytes and Bone Marrow Aspirates Chapter 29: Nervous System Cancer Biomarkers in Cerebrospinal Fluid
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