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Useful in the glycosciences, this book presents reliable protocols for the preparation of synthetic carbohydrates. Featuring worldwide contributors and a well-known series editor, the text presents new or older, not easy to find protocols generally useful to those interested in synthetic carbohydrate chemistry. Having an independent checker verify the experimental portion of the text to ensure reproducibility, the Proven Synthetic Method Series brings state-of-the-art of synthetic carbohydrate chemistry at par with general organic synthesis. Methods presented include more detailed versions of…mehr
Useful in the glycosciences, this book presents reliable protocols for the preparation of synthetic carbohydrates. Featuring worldwide contributors and a well-known series editor, the text presents new or older, not easy to find protocols generally useful to those interested in synthetic carbohydrate chemistry. Having an independent checker verify the experimental portion of the text to ensure reproducibility, the Proven Synthetic Method Series brings state-of-the-art of synthetic carbohydrate chemistry at par with general organic synthesis. Methods presented include more detailed versions of protocols that have been previously published and some new methods for the synthesis of a variety of carbohydrate derivatives.
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Autorenporträt
Series editor Pavol Ková¿, Ph.D., Dr. h.c., with more than 40 years of experience in carbohydrate chemistry and more than 270 papers published in refereed scientific journals or books, is a strong promoter of good laboratory practices and a vocal critic of the publication of experimental chemistry lacking data that allows reproducibility. He obtained an MSc in Chemistry at Slovak Technical University in Bratislava (Slovakia) and a PhD in Organic Chemistry at the Institute of Chemistry, Slovak Academy of Sciences, Bratislava. After postdoctoral training at the Department of Biochemistry, Purdue University, Lafayette, Indiana (R. L. Whistler, advisor), he returned to the Institute of Chemistry and formed a group of synthetic carbohydrate chemists, active mainly in oligosaccharide chemistry, which put the Institute on the map for quality synthetic carbohydrate chemistry. After relocating to the United States in 1981, he first worked at Bachem, Inc., Torrance, California, where he established a laboratory for production of oligonucleotides for the automated synthesis of DNA. In 1983 he joined the National Institutes of Health, where he is currently one of the Principal Investigators and Chief of the Section on Carbohydrates (NIDDK, Laboratory of Bioorganic Chemistry), the world's oldest research group continuously working on chemistry, biochemistry, and immunology of carbohydrates, originally established by America's greatest carbohydrate chemist, Claude S. Hudson. Dr. Ková¿'s main interest is in development of conjugate vaccines for bacterial diseases from synthetic carbohydrate antigens.
Inhaltsangabe
Synthetic Methods: Acetolysis of 6-Deoxysugars Controlled by Armed-Disarmed Effect. NaH/Im2SO2-Mediated Preparation of Hex-2- and Hex-3-Enopyranoside Enol Ethers. Enhancement of the Rate of Purdie Methylation by Me2S Catalysis. Synthesis of Oligosaccharides by Preactivation-Based Chemoselective Glycosylation of Thioglycosyl Donors. The Use of Hypophosphorous Acid in Radical Chain Deoxygenation of Carbohydrates. Diphenylsulfoxide-Trifluoromethanesulfonic Anhydride: A Potent Activator for Thioglycosides. Preparation of Glycosyl Chlorides from Glycopyranoses/Glycofuranoses under Mild Conditions. C-Glycosylation Starting from Unprotected O-Glycosides. Palladium-Catalyzed Sonogashira Coupling on p-Lodophenyl -d-Mannopyranoside. Synthesis by "Click Chemistry" of an -d-Mannopyranoside Having a 1,4-Disubstituted Triazole as Aglycone. Synthesis of Methyl Glycuronates by Chemo- and Regioselective TEMPO/BAIB-Oxidation. Synthesis of Sugar Nucleotides: A Phosphoramidite Approach. Conversion of N-2,2,2-Trichloroethoxycarbonyl-Protected 2-Aminoglycosides into N-Alkylated 2,3-N,O-Carbonyl Glycosides. TIBAL-Induced Rearrangement: Synthesis of gem-Difluorocarbagalactose. Pyranose-Fused Butenolides: An Expedient Preparation from Furanose Synthons. Glycal Dimerization with High Diastereoselectivity. Regioselective Debenzylation of C-Glycosylpropene. Synthesis of Azido-Functionalized Carbohydrates for the Design of Glycoconjugates. Synthesis of Thioglycosides and Thioimidates from Glycosyl Halides. Synthesis of Thioglycosides and Thioimidates from Peracetates. Synthetic Intermediates: 2-Acetamido-4,6-O-Benzylidene-2-Deoxy-d-Glucopyranose. Synthesis of 1,3,4,6-Tetra-O-Acetyl-2-Azido-2-Deoxy- ,ß-d-Glucopyranose and 2-Azido-4,6-O-Benzylidene-2-Deoxy- ,ß-d-Glucopyranose. An Easy Access to 2,3,4,6-Tetra-O-Benzyl-d-Galactopyranose and 2,3,6-Tri-O-Benzyl-d-Glucopyranose. Benzyl 2,3,6,2 ,3 ,6 -Hexa-O-Benzyl-ß-Cellobioside. One-Step Syntheses of 1,2,3,5,6-Penta-O-Benzoyl- ,ß-d-Galactofuranose and 1,2,3,5-Tetra-O-Benzoyl- ,ß-d-Arabinofuranose. Stereoselective Synthesis of -C-Sialyl Compounds. Synthesis of O-Acetylated N-Acetylneuraminic Acid Glycal. Substituted Benzyl Glycosides of N-Acetylneuraminic Acid. Synthesis of 1,5-Di-C-Alkyl 1,5-Iminoxylitols Related to 1-Deoxynojirimycin. Synthesis of 1,6-Anhydro-2,3,5-Tri-O-Benzoyl- -d-Galactofuranose. Synthesis of Prop-2-Ynyl 2,3,4,6-Tetra-O-Acetyl- -d-Mannopyranoside. Synthesis of 3-C-(2,3,4,6-Tetra-O-Acetyl-ß-d-Galactopyranosyl)prop-1-Ene. Synthesis of (E)-Methyl 4-(2,3,4,6-Tetra-O-Acetyl-ß-d-Galactopyranosyl)but-2-Enoate by Cross-Metathesis Reaction. Preparation of O-ß-d-Galactopyranosylhydroxylamine. Synthesis of 2,3,4,6-Tetra-O-Acetyl-1,5-Anhydro-d-Lyxo-Hex-1-Enitol and Its Conversion into a Hex-3-Enopyranosid-2-Ulose Analogue of Levoglucosenone. Efficient Synthesis of Methyl(Allyl 4-O-Acyl-2,3-Di-O-Benzyl-ß-d-Galactopyranosid)uronates from d-Galacturonic Acid. Methyl(Ethyl 2,3,5-Tri-O-Benzoyl-1-Thio- ,ß-d-Galactofuranosid)uronate. p-Tolyl 2,3,5-Tri-O-Benzoyl-1-Thio- -d-Arabinofuranoside: A Useful Thioglycoside Building Block in the Synthesis of Oligoarabinofuranosides. Ethylene Dithioacetals of Common Hexoses. Preparation of 2,6-Anhydro-Aldose Tosylhydrazones. Preparation of Exo-Glycals from (C-Glycopyranosyl) formaldehyde Tosylhydrazone. Synthesis of O-(6-Deoxy- - and ß-l-Galactopyranosyl) Hydroxylamines ( - and ß-l-Fucopyranosylhydroxylamines). Functionalization of Terminal Positions of Sucrose-Part I: Synthesis of 2,3,3 ,4,4 -Penta-OBenzylsucrose and Differentiation of the Terminal Positions (1,6,6 ). Functionalization of Terminal Positions of Sucrose-Part II: Preparation of 1 ,2,3,3 ,4,4 -Hexa-O-Benzylsucrose and 6,6 -Bis-O-(2-Hydroxyethyl)-1 ,2,3,3 ,4,4 -Hexa-O-Benzylsucrose.
Synthetic Methods: Acetolysis of 6-Deoxysugars Controlled by Armed-Disarmed Effect. NaH/Im2SO2-Mediated Preparation of Hex-2- and Hex-3-Enopyranoside Enol Ethers. Enhancement of the Rate of Purdie Methylation by Me2S Catalysis. Synthesis of Oligosaccharides by Preactivation-Based Chemoselective Glycosylation of Thioglycosyl Donors. The Use of Hypophosphorous Acid in Radical Chain Deoxygenation of Carbohydrates. Diphenylsulfoxide-Trifluoromethanesulfonic Anhydride: A Potent Activator for Thioglycosides. Preparation of Glycosyl Chlorides from Glycopyranoses/Glycofuranoses under Mild Conditions. C-Glycosylation Starting from Unprotected O-Glycosides. Palladium-Catalyzed Sonogashira Coupling on p-Lodophenyl -d-Mannopyranoside. Synthesis by "Click Chemistry" of an -d-Mannopyranoside Having a 1,4-Disubstituted Triazole as Aglycone. Synthesis of Methyl Glycuronates by Chemo- and Regioselective TEMPO/BAIB-Oxidation. Synthesis of Sugar Nucleotides: A Phosphoramidite Approach. Conversion of N-2,2,2-Trichloroethoxycarbonyl-Protected 2-Aminoglycosides into N-Alkylated 2,3-N,O-Carbonyl Glycosides. TIBAL-Induced Rearrangement: Synthesis of gem-Difluorocarbagalactose. Pyranose-Fused Butenolides: An Expedient Preparation from Furanose Synthons. Glycal Dimerization with High Diastereoselectivity. Regioselective Debenzylation of C-Glycosylpropene. Synthesis of Azido-Functionalized Carbohydrates for the Design of Glycoconjugates. Synthesis of Thioglycosides and Thioimidates from Glycosyl Halides. Synthesis of Thioglycosides and Thioimidates from Peracetates. Synthetic Intermediates: 2-Acetamido-4,6-O-Benzylidene-2-Deoxy-d-Glucopyranose. Synthesis of 1,3,4,6-Tetra-O-Acetyl-2-Azido-2-Deoxy- ,ß-d-Glucopyranose and 2-Azido-4,6-O-Benzylidene-2-Deoxy- ,ß-d-Glucopyranose. An Easy Access to 2,3,4,6-Tetra-O-Benzyl-d-Galactopyranose and 2,3,6-Tri-O-Benzyl-d-Glucopyranose. Benzyl 2,3,6,2 ,3 ,6 -Hexa-O-Benzyl-ß-Cellobioside. One-Step Syntheses of 1,2,3,5,6-Penta-O-Benzoyl- ,ß-d-Galactofuranose and 1,2,3,5-Tetra-O-Benzoyl- ,ß-d-Arabinofuranose. Stereoselective Synthesis of -C-Sialyl Compounds. Synthesis of O-Acetylated N-Acetylneuraminic Acid Glycal. Substituted Benzyl Glycosides of N-Acetylneuraminic Acid. Synthesis of 1,5-Di-C-Alkyl 1,5-Iminoxylitols Related to 1-Deoxynojirimycin. Synthesis of 1,6-Anhydro-2,3,5-Tri-O-Benzoyl- -d-Galactofuranose. Synthesis of Prop-2-Ynyl 2,3,4,6-Tetra-O-Acetyl- -d-Mannopyranoside. Synthesis of 3-C-(2,3,4,6-Tetra-O-Acetyl-ß-d-Galactopyranosyl)prop-1-Ene. Synthesis of (E)-Methyl 4-(2,3,4,6-Tetra-O-Acetyl-ß-d-Galactopyranosyl)but-2-Enoate by Cross-Metathesis Reaction. Preparation of O-ß-d-Galactopyranosylhydroxylamine. Synthesis of 2,3,4,6-Tetra-O-Acetyl-1,5-Anhydro-d-Lyxo-Hex-1-Enitol and Its Conversion into a Hex-3-Enopyranosid-2-Ulose Analogue of Levoglucosenone. Efficient Synthesis of Methyl(Allyl 4-O-Acyl-2,3-Di-O-Benzyl-ß-d-Galactopyranosid)uronates from d-Galacturonic Acid. Methyl(Ethyl 2,3,5-Tri-O-Benzoyl-1-Thio- ,ß-d-Galactofuranosid)uronate. p-Tolyl 2,3,5-Tri-O-Benzoyl-1-Thio- -d-Arabinofuranoside: A Useful Thioglycoside Building Block in the Synthesis of Oligoarabinofuranosides. Ethylene Dithioacetals of Common Hexoses. Preparation of 2,6-Anhydro-Aldose Tosylhydrazones. Preparation of Exo-Glycals from (C-Glycopyranosyl) formaldehyde Tosylhydrazone. Synthesis of O-(6-Deoxy- - and ß-l-Galactopyranosyl) Hydroxylamines ( - and ß-l-Fucopyranosylhydroxylamines). Functionalization of Terminal Positions of Sucrose-Part I: Synthesis of 2,3,3 ,4,4 -Penta-OBenzylsucrose and Differentiation of the Terminal Positions (1,6,6 ). Functionalization of Terminal Positions of Sucrose-Part II: Preparation of 1 ,2,3,3 ,4,4 -Hexa-O-Benzylsucrose and 6,6 -Bis-O-(2-Hydroxyethyl)-1 ,2,3,3 ,4,4 -Hexa-O-Benzylsucrose.
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