Carbohydrates as Drugs (eBook, PDF)

Redaktion: Seeberger, Peter H.; Rademacher, Christoph

• Format: PDF

Produktbeschreibung

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

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Produktdetails

• Verlag: Springer Nature Switzerland
• Seitenzahl: 237
• Erscheinungstermin: 14. November 2014
• Englisch
• ISBN-13: 9783319086750
• Artikelnr.: 43800203

Autorenporträt

PETER H. SEEBERGER is Firmenich Assistant Professor of Chemistry at the Massachusetts Institute of Technology in Cambridge, Massachusetts.

Inhaltsangabe

Carbohydrate-Based Synthetic Chemistry in the Context of Drug Design.- Iminosugars: Therapeutic Applications and Synthetic Considerations.- Computational Docking as a Tool for the Rational Design of Carbohydrate-Based Drugs.- Discovery and Development of Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Dapagliflozin for the Treatment of Type 2 Diabetes.- Design, Synthesis, and Applications of Galectin Modulators in Human Health.- Discovery and Application of FimH Antagonists.- Carbohydrate-Based Anti-Virulence Compounds Against Chronic Pseudomonas aeruginosa Infections with a Focus on Small Molecules.- The Evolution of a Glycoconjugate Vaccine for Candida albicans.