Carbohydrates in Drug Design and Discovery (eBook, PDF)

Redaktion: Jimenez-Barbero, Jesus; Martin-Santamaria, Sonsoles; Canada, F. Javier

• Format: PDF

Produktbeschreibung

In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in the area of carbohydrate drug discovery.

Carbohydrates in Drug Design and Discovery is split into five sections, beginning with a introduction and perspective on the current market. The book then goes on to discuss new synthetic methods in glycobiology, the use of glycobiology in chemical biology and glycobiology in drug discovery.

Providing a worldwide perspective on this broad area, and providing examples of therapeutics already developed using these methods, this book provides a comprehensive introduction, discussion and update on this fast developing field for medicinal chemists and biochemists working in industry and academia.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 320
• Erscheinungstermin: 30. März 2015
• Englisch
• ISBN-13: 9781849739993
• Artikelnr.: 44816323

Inhaltsangabe

Tumor associated carbohydrate antigens
Lipopolysaccharides as microbe-associated molecular patterns
Carbohydrate protein interactions at the host-pathogen interface
Glyconanotechnology and disease
Glycodendrimers for drug discovery
Chemical glycobiology of infection
Glycosylated antitumor ether lipids
Synthesis of novel molecules for glycobiology and glycomedicine
The development of innovative strategies towards glycovaccines
Carbohydrates and glycomimetics in neurodiseases
Glycosyl-containing inhibitors of Matrix Metallo Proteinases
Design and synthesis of novel molecules as mechanistic probes for carbohydrate-mediated biological recognition
The development of the Haemophilus influenzae type b (Hib) vaccine using a synthetic antigen
Carbohydrate-Protein Interactios: A 3D view by NMR and modeling
Inhibition of enzyme activity (glycosides and gycosyl hydrolase enzymes) using multivalent analogs
Mycobacterium tuberculosis and C-type lectins
New tools for chemical medicine: From synthesis to applications