Cell and Matrix Mechanics (eBook, PDF)

Redaktion: Kaunas, Roland; Zemel, Assaf

• Format: PDF

Produktbeschreibung

This book covers several key areas of cell and tissue mechanics, providing the data and modeling framework for a multiscale analysis. The first section introduces basic concepts and outlines popular approaches used to study the mechanical properties of cells and matrix. The following two sections focus on molecular-scale studies of subcellular and matrix protein mechanics. The third section focuses on cell-cell and cell-matrix interactions. The final section deals with studies at the tissue scale.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 376
• Erscheinungstermin: 23. Oktober 2014
• Englisch
• ISBN-13: 9781466553828
• Artikelnr.: 57081837

Autorenporträt

Roland Kaunas is an associate professor of biomedical engineering and the director of the Cell Mechanobiology Laboratory at Texas A&M University. He earned his BS in chemical engineering at the University of Wisconsin, his MS in biomedical engineering at Northwestern University, and his PhD in bioengineering from the University of California, San Diego. He joined the faculty at Texas A&M in 2005. His research focuses on experimental and computational modeling of cell reorganization and mechanotransduction in response to matrix stretching, fluid shear stress mechanotransduction in sprouting angiogenesis, and the development of collagen-based scaffolds for adult stem cell delivery for osteoregenerative therapies. Assaf Zemel is a senior lecturer of theoretical biophysics and head of theoretical biophysics laboratory at the Institute of Dental Sciences at the Hebrew University of Jerusalem. He is also affiliated with the Fritz Haber Research Center for Molecular Dynamics at the Center for Bioengineering of the Hebrew University. Assaf earned his PhD in theoretical chemistry from the Hebrew University. He then shifted to the field of cell mechanics for his postdoctoral research. His current research focuses on understanding the physical mechanisms underlying the morphology, dynamics and internal structure of cells, and the mechanics of cell-cell interactions and morphogenesis.

Inhaltsangabe

Active Mechanics of the Cytoskeleton. Mechanobiology of the Cell Membrane.
Cellular Reconstitution of Actively Self-Organizing Systems. Structural and
Dynamical Hierarchy of Fibrillar Collagen. Cell-Matrix and Cell-Cell
Mechanical Interactions. Dynamic Stress Fiber Reorganization on Stretched
Matrices. Mechanics of Cell-Seeded ECM Scaffolds. Cell Motility in 3D
Matrices. Collective Cell Migration. Connective Tissue Development.
Cellular Forces in Morphogenesis. Mechanics of Tissue Morphogenesis.
Continuum Physics of Tumor Growth. Cell Force-Mediated Collagen Remodeling
in Cancer Metastasis. Index.