Cells and Culture (eBook, PDF)

Proceedings of the 20th ESACT Meeting, Dresden, Germany, June 17-20, 2007
Redaktion: Noll, Thomas

• Format: PDF

Produktbeschreibung

It has been predicted that nearly half of all human proteins are glycosylated indicating the significance of glycoproteins in human health and disease. For example, the glycans attached to proteins have emerged as important biomarkers in the diagnosis of diseases such as cancers and play a significant role in how pathogenic viruses gain entry into human cells. The study of glycoproteins has now become a truly proteomic science. In the last few years, technology developments including in silico methods, high throughput separation and detection techniques have accelerated the characterization of glycoproteins in cells and tissues. Glyco-engineering coupled to rapid recombinant protein production has facilitated the determination of glycoprotein structures key to exploring and exploiting their functional roles. Each chapter in this volume is written by experts in the field and together provide a review of the state of the art in the emerging field of glycoproteomics.

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Produktdetails

• Verlag: Springer Netherlands
• Seitenzahl: 800
• Erscheinungstermin: 17. Juli 2010
• Englisch
• ISBN-13: 9789048134199
• Artikelnr.: 37413389

Autorenporträt

Dr. Thomas Noll, geboren 1962, Studium der Kunstgeschichte, der Klassischen Archäologie sowie der Mittleren und Neueren Geschichte in Göttingen und Heidelberg. 1991 Promotion in Göttingen, danach Forschungsstipendiat am Zentralinstitut für Kunstgeschichte in München. 2001 Habilitation. Lehrtätigkeit in Augsburg und Göttingen. Zahlreiche Veröffentlichungen - hauptsächlich zur Kunst des späten Mittelalters, des 19. und frühen 20. Jahrhunderts.

Inhaltsangabe

Preface;Glycoproteomics in Health and Disease, W.B. Struwe, E.F.J. Cosgrave, J.C. Byrne, R. Saldova, P.M. Rudd.;Glyco-engineering of Fc Glycans to the Biological Functions in Therapeutic IgGs, T. Shantra Raju, D.M. Knight, R.E. Jordan;Bioinformatics Databases and Applications Available for Glycobiology and Glycomics, R. Ranzinger, K. Maabeta, T. Lütteke;Lectin Microarrays: simple tools for the analysis of complex glycans, L. Krishnamoorthy and L.K. Mahal;The Application of High Throughput Mass Spectrometry to the Analysis of Glycoproteins, S. Singh, M.T. Andersen, J.J. Steen;Solutions to the Glycosylation Problem for Low- and High-Throughput Structural Glycoproteomics, S.J. Davis and M. Crispin;Role of Glycoproteins in Virus-Human Cell Interactions, T.A. Bowden and E.E. Fry;Subject Index