Leland N. Jr. Edmunds

Cellular and Molecular Bases of Biological Clocks (eBook, PDF)

Models and Mechanisms for Circadian Timekeeping

• Format: PDF

Produktbeschreibung

An intriguing class of biological periodicity consists of rhythms with about 24-hour periods occurring at every level of eukaryotic organization. Progress is being made in understanding these rhythms. The six chapters of this work include a brief introduction to circadian (24-hour) rhythms, a survey of circadian organization at the cellular level, and a description of the important microorganisms that have served as experimental models for biochemical analysis. Also considered are relations between cell division cycles and circadian oscillators, as well as some general and theoretical aspects. Where appropriate, parallels are drawn to neuronal oscillators. This volume will introduce and critically appraise modern chronobiology; its extensive illustrations and comprehensive up-to-date bibliography will make it an authoritative reference.

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Produktdetails

• Verlag: Springer New York
• Seitenzahl: 497
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9781461237426
• Artikelnr.: 43991795

Inhaltsangabe

1. Introduction.- 1.1 Temporal Organization.- 1.2 General Properties of Circadian Rhythms.- 1.3 Analogies with Shorter Periodicities.- 2. Circadian Organization in Eukaryotic Microorganisms.- 2.1 Circadian Rhythms in Protozoa.- 2.2 Circadian Rhythms in Unicellular Algae.- 2.3 Circadian Rhythms in Fungi.- 3. Cell Cycle Clocks.- 1.1 Regulation of the Cell Division Cycle.- 3.2 Cell Division Cycles and Circadian Oscillators.- 4. Experimental Approaches to Circadian Clock Mechanisms.- 4.1 Quest for an Anatomical Locus: Autonomous Oscillators in Isolated Organs, Tissues, and Cells.- 4.2 Tracing the Entrainment Pathway for Light Signals.- 4.3 Dissection of the Clock: Perturbation by Chemicals.- 4.1 Dissection of the Clock: Molecular Genetics.- 4.5 Characterizing the Coupling Pathway: Transducing Mechanisms Between Clocks and Their Hands.- 5. Biochemical and Molecular Models for Circadian Clocks.- 5.1 In Vitro Molecular Models.- 5.2 Biochemical Feedback Loop and Network Models.- 5.1 Transcriptional (Tape-Reading) Models.- 5.2 Membrane Models.- 5.3 Problems and Prospects.- 6. General Considerations and Conclusions.- 6.1 Evolution of Circadian Rhythmicity.- 6.2 Multiple Cellular Oscillators.- 6.3 The Breakdown of Temporal Organization at the Cellular Level.- 6.4 Cellular Aspects of Chronopharmacology and Chronotherapy.- 6.5 Cellular Clocks in Development and Aging.- 6.6 Epilogue.- References.- Author Index.