Proceedings of an international conference held in Magdeburg, Germany, November 3-5, 1996
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Inhaltsangabe
I: Membrane Peptidases in Immune Functions and Inflammation.- 1. Membrane Metalloendopeptidases in Immune Function and Disease.- 2. Structural Studies of Aminopeptidase P: A Novel Cellular Peptidase.- 3. Aminopeptidase P: A Cell-Surface Antigen of Endothelial and Lymphoid Cells.- 4. Human Lymphocyte X-Prolyl Aminopeptidase (Aminopeptidase P)-like Protein: A New Member of the Proline Peptidase Family?.- 5. Specific Inhibitors of Aminopeptidase P: Peptides and Pseudopeptides of 2-Hydroxy-3-Amino Acids.- 6. ?-Glutamyl Transpeptidase, a Blood-Brain Barrier Associated Membrane Protein: Splitting Peptides to Transport Amino Acids.- 7. Structure and Expression of Aminopeptidase N.- 8. Activation-Dependent Induction of T Cell Alanyl Aminopeptidase and Its Possible Involvement in T Cell Growth.- 9. Antisense-Mediated Inhibition of Aminopeptidase N (CD13) Markedly Decreases Growth Rates of Hematopoietic Tumour Cells.- 10. Co-Incubation of Lymphocytes with Fibroblast-like Synoviocytes and Other Cell Types Can Induce Lymphocytic Surface Expression of Aminopeptidase N/CD13.- 11. Two Transfected Endothelial Cell Lines Expressing High Levels of Membrane Bound or Soluble Aminopeptidase N.- 12. Aminopeptidase N-Mediated Signal Transduction and Inhibition of Proliferation of Human Myeloid Cells.- 13. Regulation of Thymic Development by Neprilysin Inhibition.- 14. Proteases of Isolated Pancreatic Acinar Cells after Caerulein Hyperstimulation.- II: CD26/Dipeptidylpeptidase IV on Lymphocytes.- 15. Structure of CD26 (Dipeptidyl Peptidase IV) and Function in Human T Cell Activation.- 16. Molecular Associations Required for Signalling via Dipeptidyl Peptidase IV (CD26).- 17. CD26/Dipeptidyl Peptidase IV in Lymphocyte Growth Regulation.- 18. CD26 Is Involved in Regulation of CytokineProduction in Natural Killer Cells.- 19. The Effect of Anti-CD26 Antibodies on DNA Synthesis and Cytokine Production (IL-2, IL-10 and IFN-?) Depends on Enzymatic Activity of DP IV/CD26.- 20. New Fluorogenic Dipeptidyl Peptidase IV/CD26 Substrates and Inhibitors.- 21. Molecular Analyses of Human and Rat Dipeptidyl Peptidase IV.- 22. A Molecular Model of the Active Site of Dipeptidyl Peptidase IV: Explanation of the Substrate Specificity and Interaction with Inhibitors.- 23. The Level of CD26 Determines the Rate of HIV Entry in a CD4+ T-Cell Line.- 24. HIV-1 Envelope gp 120 and Viral Particles Block Adenosine Deaminase Binding to Human CD26.- 25. Further Characterization of DPP IV-?, a Novel Cell Surface Expressed Protein with Dipeptidyl Peptidase Activity.- 26. Expression of Dipeptidylpeptidase IV (DPP IV/CD26) Activity on Human Myeloid and B Lineage Cells, and Cell Growth Suppression by the Inhibition of DPP IV Activity.- 27. CD26 as a Positive Regulator of HIV Envelope-Glycoprotein Induced Apoptosis in CD4+ T Cells.- 28. Comparative Study of CD26 as a Thl-like and CD30 as a Potential Th2-like Operational Marker in Leprosy.- III: Peptidases Involved in Cytokine Actions and in the Pathogenesis of Disease.- 29. Regulation of Neutrophil Activation by Proteolytic Processing of Platelet-Derived a-Chemokines.- 30. Selective Proteolytical Cleavage of the Ligand-Binding Chains of the IL-2-Receptor and IL-6-Receptor by Neutrophil-Derived Proteases.- 31. In Vitro Effects of ?-Glutamyltranspeptidase Inhibitor Acivicin on Human Myeloid and B Lineage Cells.- 32. Expression of Several Matrix Metalloproteinase Genes in Human Monocytic Cells.- 33. Lysosomal Cysteine Peptidases and Malignant Tumours.- 34. Expression of Cysteine Protease Inhibitors Stefin A, Stefin B, and Cystatin Cin Human Lung Tumor Tissue.- 35. Contribution of the Proteasome to the a-Secretase Pathway in Alzheimer's Disease.- 36. Dipeptidyl Peptidase IV (CD26) and Alzheimer Amyloid Protein Precursor (APP) in Polymyositìs.- 37, The HIV Protease and Therapies for AIDS.- 38. Leukodiapedesis, Function, and Physiological Role of Leucocyte Matrix Metalloproteinases.- 39. Matrix Metalloproteinases in Experimental Autoimmune Encephalomyelitis.- 40. Interaction of Transforming Growth Factor ß (TGFß) with Proteinase 3.- 41. Liver Cysteine Proteinases in Macrophage Depression Induced by Gadolinium Chloride.- Contributors.
I: Membrane Peptidases in Immune Functions and Inflammation.- 1. Membrane Metalloendopeptidases in Immune Function and Disease.- 2. Structural Studies of Aminopeptidase P: A Novel Cellular Peptidase.- 3. Aminopeptidase P: A Cell-Surface Antigen of Endothelial and Lymphoid Cells.- 4. Human Lymphocyte X-Prolyl Aminopeptidase (Aminopeptidase P)-like Protein: A New Member of the Proline Peptidase Family?.- 5. Specific Inhibitors of Aminopeptidase P: Peptides and Pseudopeptides of 2-Hydroxy-3-Amino Acids.- 6. ?-Glutamyl Transpeptidase, a Blood-Brain Barrier Associated Membrane Protein: Splitting Peptides to Transport Amino Acids.- 7. Structure and Expression of Aminopeptidase N.- 8. Activation-Dependent Induction of T Cell Alanyl Aminopeptidase and Its Possible Involvement in T Cell Growth.- 9. Antisense-Mediated Inhibition of Aminopeptidase N (CD13) Markedly Decreases Growth Rates of Hematopoietic Tumour Cells.- 10. Co-Incubation of Lymphocytes with Fibroblast-like Synoviocytes and Other Cell Types Can Induce Lymphocytic Surface Expression of Aminopeptidase N/CD13.- 11. Two Transfected Endothelial Cell Lines Expressing High Levels of Membrane Bound or Soluble Aminopeptidase N.- 12. Aminopeptidase N-Mediated Signal Transduction and Inhibition of Proliferation of Human Myeloid Cells.- 13. Regulation of Thymic Development by Neprilysin Inhibition.- 14. Proteases of Isolated Pancreatic Acinar Cells after Caerulein Hyperstimulation.- II: CD26/Dipeptidylpeptidase IV on Lymphocytes.- 15. Structure of CD26 (Dipeptidyl Peptidase IV) and Function in Human T Cell Activation.- 16. Molecular Associations Required for Signalling via Dipeptidyl Peptidase IV (CD26).- 17. CD26/Dipeptidyl Peptidase IV in Lymphocyte Growth Regulation.- 18. CD26 Is Involved in Regulation of CytokineProduction in Natural Killer Cells.- 19. The Effect of Anti-CD26 Antibodies on DNA Synthesis and Cytokine Production (IL-2, IL-10 and IFN-?) Depends on Enzymatic Activity of DP IV/CD26.- 20. New Fluorogenic Dipeptidyl Peptidase IV/CD26 Substrates and Inhibitors.- 21. Molecular Analyses of Human and Rat Dipeptidyl Peptidase IV.- 22. A Molecular Model of the Active Site of Dipeptidyl Peptidase IV: Explanation of the Substrate Specificity and Interaction with Inhibitors.- 23. The Level of CD26 Determines the Rate of HIV Entry in a CD4+ T-Cell Line.- 24. HIV-1 Envelope gp 120 and Viral Particles Block Adenosine Deaminase Binding to Human CD26.- 25. Further Characterization of DPP IV-?, a Novel Cell Surface Expressed Protein with Dipeptidyl Peptidase Activity.- 26. Expression of Dipeptidylpeptidase IV (DPP IV/CD26) Activity on Human Myeloid and B Lineage Cells, and Cell Growth Suppression by the Inhibition of DPP IV Activity.- 27. CD26 as a Positive Regulator of HIV Envelope-Glycoprotein Induced Apoptosis in CD4+ T Cells.- 28. Comparative Study of CD26 as a Thl-like and CD30 as a Potential Th2-like Operational Marker in Leprosy.- III: Peptidases Involved in Cytokine Actions and in the Pathogenesis of Disease.- 29. Regulation of Neutrophil Activation by Proteolytic Processing of Platelet-Derived a-Chemokines.- 30. Selective Proteolytical Cleavage of the Ligand-Binding Chains of the IL-2-Receptor and IL-6-Receptor by Neutrophil-Derived Proteases.- 31. In Vitro Effects of ?-Glutamyltranspeptidase Inhibitor Acivicin on Human Myeloid and B Lineage Cells.- 32. Expression of Several Matrix Metalloproteinase Genes in Human Monocytic Cells.- 33. Lysosomal Cysteine Peptidases and Malignant Tumours.- 34. Expression of Cysteine Protease Inhibitors Stefin A, Stefin B, and Cystatin Cin Human Lung Tumor Tissue.- 35. Contribution of the Proteasome to the a-Secretase Pathway in Alzheimer's Disease.- 36. Dipeptidyl Peptidase IV (CD26) and Alzheimer Amyloid Protein Precursor (APP) in Polymyositìs.- 37, The HIV Protease and Therapies for AIDS.- 38. Leukodiapedesis, Function, and Physiological Role of Leucocyte Matrix Metalloproteinases.- 39. Matrix Metalloproteinases in Experimental Autoimmune Encephalomyelitis.- 40. Interaction of Transforming Growth Factor ß (TGFß) with Proteinase 3.- 41. Liver Cysteine Proteinases in Macrophage Depression Induced by Gadolinium Chloride.- Contributors.
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