Cerebral Ischemia (eBook, PDF)

Molecular and Cellular Pathophysiology
Redaktion: Walz, Wolfgang

• Format: PDF

Produktbeschreibung

In Cerebral Ischemia: Molecular and Cellular Pathphysiology, Wolfgang Walz and a panel of leading authorities illuminate those cellular and molecular mechanisms brought into play during a stroke that lead to neuronal dysfunction. Such damaging factors as spreading depression waves and postischemic depolarization, cell swelling, calcium overload, and oxygen radicals leading to necrosis and apoptosis are described in detail. Also examined are the body's repair mechanisms involving altered gene expression that lead to trophic factor production and heat shock protein synthesis, as well as to astrogliosis and microgliosis. All factors are presented in relation to their therapeutic value and the possible treatment approaches that evolve from their interactions. Cerebral Ischemia: Molecular and Cellular Pathophysiology offers clinicians, interested practitioners, and experimentalists alike a systematic evaluation of all the major biological systems that contribute to brain dysfunction after a vascular accident. Its unique focus on mechanisms and gene expression also provides fresh and powerful insights into the many novel therapeutic strategies and agents for stroke management emerging today.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 278
• Erscheinungstermin: 25. März 1999
• Englisch
• ISBN-13: 9781592594795
• Artikelnr.: 44062869

Inhaltsangabe

1 Mechanisms of Cerebral Ischemic Damage.- 2 Spreading Depression Waves as Mediators of Secondary Injury and of Protective Mechanisms.- 3 Cell Swelling in Cerebral Ischemia.- 4 Calcium Overload.- 5 Oxygen Radicals.- 6 Mechanisms of Neuroprotective Cytokines: Pleiotrophic Effects of TNF? and TGF? on Brain Injury.- 7 Reprogramming of Gene Expression After Ischemia.- 8 Neurons: Necrotic vs Apoptotic Changes.- 9 Reactive Astrogliosis in the Injured and Postischemic Brain.- 10 Activated and Phagocytic Microglia.

Rezensionen

"...The book will be useful for new entrants to the field of cerebral ischaemia and will also be of value to workers in the field who wish to get up to speed in aspects in which they are not primarily active. The reviews are, on the whole, well written and extensively referenced, and personally, I found the chapters on gene expression and cytokines most interesting." -Brain

"...a clear source of knowledge for interested practitioners....The first part gives a clear overview of the mechanisms involved in cerebral ischemic damage....Each chapter of this book can be consulted on itself. Nevertheless, it gives a very homogeneous and coherent impression."-Acta Neurologica Belgica

"In this book, the editor, Wolfgang Walz, and a panel of experts in the field of cerebral ischemia give a broad insight into the current knowledge of molecular and cellular events occurring in the brain parenchyma during cerebral ischemia. The book is well structured....this book gives auseful summary of molecular and cellular aspects of cerebral ischemia, its length (284 pp.) makes it easily readable, and it can be recommended as an introduction to the field of clinicians and researchers interested in stroke."-European Neurology

"The author reviews also multiple therapeutic strategies corresponding to those various events induced by brain ischaemia....Very fundamental data related to the last developments of molecular biology, such as the reprogramming of gene expression after ischaemia and the neuronal death due to necrosis or apoptosis, are emphasized...Experts in the fields wrote the various chapters that include a very extensive bibliography. The book can be recommended to scientists concerned with basic mechanisms of brain ischaemia as well as to clinicians whose goal is the prevention of irreversible brain damage and he development of new therapies."-Acta Cardiologica