Chemical Genomics (eBook, ePUB)

Redaktion: Fu, Haian

• Format: ePub

Produktbeschreibung

Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small-molecule chemicals; the basics of high-throughput screening technologies; and various bioassays for biochemical-, cellular- and organism-based screens. The final chapters connect the chemical genomics field with personalized medicine and the druggable genome for future discovery of new therapeutics. This book will be valuable to researchers, professionals and graduate students in many fields, including biology, biomedicine and chemistry.

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Produktdetails

• Verlag: Cambridge University Press
• Erscheinungstermin: 13. Februar 2012
• Englisch
• ISBN-13: 9781139234269
• Artikelnr.: 52827242

Inhaltsangabe

Part I. Overviews: 1. Harnessing the power of chemistry for biology and
medicine Cheryl L. Meyerkord and Haian Fu; 2. Chemical genomics: exploring
biology with small organic molecules Nicholas Aberle and Craig M. Crews; 3.
Chemical proteomics Akihisa Matsuyama, Yoko Yashiroda and Minoru Yoshida;
Part II. Molecules for Chemical Genomics: 4. Diversity-oriented synthesis
Warren R. J. D. Galloway, Richard J. Spandl, Andreas Bender, Gemma L.
Thomas, Monica Diaz-Gavilan, Kieron M. G. O'Connell and David R. Spring; 5.
Targeted chemical libraries Gregory P. Tochtrop and Ryan E. Looper; 6.
Fragment-based ligand discovery Sandra Bartoli, Antonella Squarcia and
Daniela Fattori; 7. Basics and principles for building natural
product-based libraries for HTS Ronald J. Quinn; Part III. Basics of High
Throughput Screening: 8. Essentials for high throughput screening
operations Stewart P. Rudnicki, James V. Follen, Nicola J. Tolliday and
Caroline E. Shamu; 9. High content analysis and screening: basics,
instrumentation and applications Paul A. Johnston; 10. Phenotypic screens
with model organisms Grant N. Wheeler, Robert A. Field and Matthew L.
Tomlinson; 11. Screening informatics and ChemInformatics Lestyn Lewis; Part
IV. Chemical Genomics Assays and Screens: 12. Basics on HTS assay design
and optimization Eduard Sergienko; 13. Molecular sensors for
transcriptional and post-transcriptional assays Douglas S. Auld and Natasha
Thorne; 14. Fluorescence-based platforms for HTS assays - FP and TR-FRET
Yuhong Du and Jonathan Havel; 15. Compound profiling with high content
screening methodology Thomas Mayer and Stephan Schürer; 16. Use of
transgenic zebrafish in a phenotypic screen for angiogenesis inhibitors
Jaeki Min, Yuhong Du, Brenda Bondesen, Brian Revennaugh, Peter Eimon and
Ray Dingledine; 17. Flow cytometry multiplexed screening methodologies
Virginia M. Salas, J. Jacob Strouse, Zurab Surviladze, Irena
Ivnitski-Steele, Bruce S. Edwards and Larry A. Sklar; 18. Basic principles
and practices of computer-aided screening and drug design Chao-Yie Yang,
Denzil Bernard and Shaomeng Wang; 19. Computational approach for drug
target identification Honglin Li, Mingyue Zheng, Xiaofeng Liu and Hualiang
Jiang; 20. Label-free biosensor technologies for assay development and HTS
Yuhong Du and Arron Xu; Part V. Chemical Genomics and Medicine: 21.
Pharmacogenomics to link genetic background with therapeutic efficacy and
safety Mark M. Bouzyk, Weining Tang and Brian Leyland-Jones; 22. Drugs,
genomic response signatures, and customized cancer therapy Rafael Rosell,
Teresa Moran and Miguel Taron; Appendix. Current drug targets and the
druggable genome Andreas Russ.