Chemistry and Biology of O-GlcNAcylation (eBook, PDF)

Redaktion: Yi, Wen

• Format: PDF

Produktbeschreibung

O-linked N-acetylglucosamine (O-GlcNAc) is a prevalent post-translational modification of numerous intracellular proteins. This modification has recently emerged as a key regulator of various important biological processes, including gene transcription, stress response, metabolic homeostasis, and immune regulation. Given the critical role of O-GlcNAc in normal physiology, increasing evidence has now demonstrated that deregulation of O-GlcNAc is closely associated with the development and progression of various diseases, including neurodegeneration, cardiovascular disease, and cancer. This book provides a comprehensive overview of the current progress and understanding of this modification in biology, and likely provides new research directions in the future.

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Produktdetails

• Verlag: Springer Nature Singapore
• Seitenzahl: 178
• Erscheinungstermin: 13. Oktober 2024
• Englisch
• ISBN-13: 9789819748648
• Artikelnr.: 71915964

Autorenporträt

Dr. Wen Yi is professor of College of Life Sciences, Zhejiang University, China. His research focuses on glycobiology, chemical biology, post-translational modification of proteins, and regulatory mechanisms of cellular metabolism.

Inhaltsangabe

Chapter 1. Chemical tools for decoding the functions of O-GlcNAcylation.- Chapter 2. Profiling O-GlcNAcylation with mass spectrometry.- Chapter 3. O-GlcNAcylation and cell metabolism.- Chapter 4. O-GlcNAcylation and transcriptional regulation and epigenetics.- Chapter 5. O-GlcNAcylation and signal transduction.- Chapter 6. O-GlcNAcylation and stem cells.- Chapter 7. O-GlcNAcylation and immune regulation.- Chapter 8. O-GlcNAcylation and neuronal development, neurodegeneration and neurological disorders.