Chemokine Receptors in Cancer (eBook, PDF)

Redaktion: Fulton, Amy M.

• Format: PDF

Produktbeschreibung

Chemokine Receptors in Cancer summarizes the growing body of evidence that several chemokine receptors contribute to tumor behavior. Chemokine receptors were first identified on leukocytes and mediate directed migration of many host cells to sites of ligand expression. It is now well established that most malignant cells also express one or more chemokine receptor. This book describes our current understanding regarding how chemokine receptors contribute to tumor cell migration as well as cell survival and proliferation. The function of chemokine receptors expressed on host cells including antitumor immune effector cells as well as angiostatic and angiogeneic functions of chemokines acting on endothelial cells are described. The role of chemokine receptors that act as decoy receptors is also summarized. The therapeutic potential and challenges of targeting chemokine receptors or cognate ligands is also addressed.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 172
• Erscheinungstermin: 12. Juni 2009
• Englisch
• ISBN-13: 9781603272674
• Artikelnr.: 37342352

Inhaltsangabe

Chemokines and Chemokine Receptors in Cancer Progression.- CXCR4 and Cancer.- HIF-1 Regulation of Chemokine Receptor Expression.- Chemokine Receptors Involved in Colon Cancer Progression, and Lymph Node Metastasis.- The CXCR3/CXCL3 Axis in Cancer.- Roles for CCR7 in Cancer Biology.- The CCL5/CCR5 Axis in Cancer.- CXC Chemokines in Cancer Angiogenesis.- The Roles of Chemokines and Chemokine Receptors in Prostate Cancer.

Rezensionen

From the reviews:

"This book will appeal to a broad audience. It is useful for anyone who is interested in the area of chemokines and their receptors in cancer, including students, established investigators, and clinicians. ... The book provides a nice, concise summary of the evidence for the role of chemokine receptors in cancer. ... this book largely focuses on the role of chemokine receptors on tumor cells themselves and effects on angiogenesis, progression, and metastasis, adding significantly to our current knowledge about cancer." (Cheryl E. Rockwell, Doody's Review Service, December, 2009)

"Report the progress of chemokine and chemokine receptor study in cancer-therapy-related research. ... provides an overview that is useful not only to researchers focusing on cancer immunology research, but also to graduate students and postdoctoral associates who have just started working in this area. ... the book not only attractive to cancer biologists, but also to medicinal chemists and pharmacologists working in the field of anticancer drug discovery. ... applied as a reasonable starting point for cancer researchers to grasp the progress in this area." (Yan Zhang, ChemMedChem, Vol. 5, 2010)