Chemosensitivity Testing in Oncology (eBook, PDF)

Redaktion: Reinhold, Uwe; Tilgen, Wolfgang

• Format: PDF

Produktbeschreibung

Over the past 50 years many in vitro and in vivo drug response assay systems have been developed to determine the potential - tivity of chemotherapy agents. The idea was to eliminate ineffective agents and unnecessary toxic treatment while selecting drugs active in vitro or in the mouse model that might increase the probability of response in the patient. None of these test models, however, achieved routine clinical application in the past. This might be at least in part - lated to large discrepancies that were described between the s- cess rate of the assay systems and the clinical benefit in cancer - tients. The heterogeneity of chemosensitivity that exists between different tumors as well as between individual tumor lesions may be one explanation for these findings. Furthermore, different assay end points such as proliferation, metabolism, and vitality were - veloped to evaluate the effects of cytostatic drugs on tumor cells, and these might be related to the differing results. However, knowledge about procedures for assay-assisted treatment selection has increased rapidly within the past few years, and several studies suggest that test-directed chemotherapy selection now may - prove response rates and survival in various types of tumors. The International Society for Chemosensitivity Testing in - cology (ISCO) was founded to promote, coordinate, and improve clinical and laboratory research in the field of predictive drug te- ing in human tumor cells.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 245
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9783642190223
• Artikelnr.: 53150080

Autorenporträt

Uwe Reinhold, Universitätskliniken des Saarlandes, Homburg/Saar, Germany / Wolfgang Tilgen, Universitätskliniken des Saarlandes, Homburg/Saar, Germany

Inhaltsangabe

From the contents: Luminescence applications for chemotherapeutic drug development. The use of the MTT assay to study drug resistance in fresh tumor samples. Multiparametric sensor chips for chemosensitivity testing of sensitive and resistant tumor cells. Development of a new in vitro chemosensitivity test using collagen gel droplet-embedded culture and image analysis for clinical usefulness. In vitro chemosensitivity testing of haematological cancer patients: detection of ornithine decarboxylase.- The chemosensitivity profile of retinoblastoma. Chemosensitivity testing in malignant melanoma. Humanmelanoma: drug-resistance. Cisplatin, doxorubicin and paclitaxel induce MDR1-gene transcription in ovarian cancer cell lines.- Chemosensitivity testing as an aid to anti-cancer drug regimen development. Assay-assisted treatment selection for women with breast or ovarian cancer. Treosulfan in the treatment of metastatic melanoma. ATP chemosensitivity testing in ovarian and breast cancer.