Childhood Leukemias (eBook, PDF)

Redaktion: Pui, Ching-Hon

• Format: PDF

Produktbeschreibung

New insights into the molecular biology of childhood leukemias have stimulated numerous advances in diagnostic methods, strategies for risk assessment and the development of novel therapy for genetic subtypes of the diseases. Fully revised and updated, this new edition of Childhood Leukemias provides the most comprehensive, clinically-oriented and authoritative reference dedicated to these diseases. Beginning with an overview of history, cell biology, and pathology, subsequent chapters review approaches in the evaluation and management of specific leukemias, new therapeutic development and the unique pharmacodynamics and pharmacogenetics of individual patients. New chapters include epigenetics of leukemias, leukemias in patients with Down syndrome and leukemia in adolescents and young adults. The final section covers the complications associated with the disease or its treatment and supportive care during and after treatment. Authored by leading experts, this is a 'must-have' for any physician or investigator who deals with leukemias in childhood.

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Produktdetails

• Verlag: Cambridge University Press
• Erscheinungstermin: 21. Juni 2012
• Englisch
• ISBN-13: 9781139511926
• Artikelnr.: 38278978

Inhaltsangabe

Preface; Part I. History and General Issues: 1. History of leukemia Paul
Gaynon, Toska Zomorodian and Donald Pinkel; 2. Diagnosis and classification
Mihaela Onciu and Ching-Hon Pui; 3. Epidemiology and etiology Logan
Spector, Bridget Charbonneau and Leslie L. Robison; Part II. Cell Biology
and Pathobiology: 4. Immunophenotyping Fred G. Behm; 5. Immunoglobulin and
T-cell receptor gene rearrangements Jacques J. M. van Dongen and Anton W.
Langerak; 6. Cytogenetics of acute leukemias Susana C. Raimondi; 7.
Molecular genetics of acute lymphoblastic leukemias Charles Mullighan; 8.
Molecular genetics of acute myeloid leukemia Tanja A. Gruber and James R.
Downing; 9. Epigenetics of leukemias William Stevenson and Guillermo
Garcia-Manero; 10. Genetics and cellular drug resistance in acute leukemia
Monique L. den Boer and Rob Pieters; 11. Heritable predispositions to
childhood hematologic malignancies Doan Le, Kevin Shannon and Beverly J.
Lange; Part III. Evaluation and Treatment: 12. Pharmacokinetic,
pharmacodynamic, and pharmacogenetic considerations Stephen W. Paugh, Mary
V. Relling and Williams E. Evans; 13. Acute lymphoblastic leukemia
Ching-Hon Pui; 14. Relapsed acute lymphoblastic leukemia Günter Henze and
Arend von Stackelberg; 15. B-cell acute lymphoblastic leukemia and Burkitt
lymphoma John T. Sandlund and Mihaela Onciu; 16. Acute myeloid leukemia
Jeffrey E. Rubnitz, Hiroto Inaba and Raul Ribeiro; 17. Relapsed acute
myeloid leukemia Ursula Creutzig; 18. Myelodysplastic syndromes Henrik
Hasle; 19. Chronic myeloproliferative disorders Charlotte M. Niemeyer and
Franco Locatelli; 20. Leukemias in patients with Down syndrome Jeffrey W.
Taub, April Sorrell and James A. Whitlock; 21. Treatment of adolescents and
young adults with acute lymphoblastic leukemia James Nachman; 22.
Hematopoietic stem cell and natural killer cell transplantation Wing Leung
and Michael A. Pulsipher; 23. Treatment in the underprivileged countries
Raul Ribeiro, Scott C. Howard and Ching-Hon Pui; 24. Antibody-targeted
therapy Alan S. Wayne; 25. Adoptive cellular immunotherapy Hyoung Jin Kang,
Cliona M. Rooney and Helen Heslop; 26. Gene therapy: methods and
applications Ulrike Gerdemann, Martin Pulé and Malcolm K. Brenner; 27.
Development therapeutics Sima Jeha; 28. Minimal residual disease Dario
Campana, Andrea Biondi and Jacques J. M. van Dongen; Part IV. Complications
and Supportive Care: 29. Acute complications Scott C. Howard, Raul Ribeiro
and Ching-Hon Pui; 30. Late complications after leukemia therapy Melissa
Hudson; 31. Therapy-related leukemias Carolyn A. Felix; 32. Infectious
complications Hana Hakim and Patricia M. Flynn; 33. Hematologic supportive
care Fariba Navid and Victor M. Santana; 34. Pain management Doralina L.
Anghelescu and Roland Kaddoum; 35. Psychosocial issues Sean Phipps, Vida L.
Tyc, Heather Conklin and Kevin Krull; 36. Nursing care Jami S. Gattuso,
Martha May and Michele Pritchard; Index.