Chromatin and Disease (eBook, PDF)

Redaktion: Kundu, Tapas K.; Dasgupta, Dipak

• Format: PDF

Produktbeschreibung

This book includes a collection of articles with the broad theme of disease connection to chromatin structure and function. It elaborates on the molecular pharmacology of the drugs targeting chromatin structure and its components. The book contains up-to-date information about the chromatin structure and chromatin related diseases and drug functions. This work is the first endeavor to present different aspects encompassing the above theme.

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Produktdetails

• Verlag: Springer Netherlands
• Seitenzahl: 458
• Erscheinungstermin: 4. Mai 2007
• Englisch
• ISBN-13: 9781402054662
• Artikelnr.: 37346051

Autorenporträt

Tapas K. Kundu, Jawaharlal Centre for Advanced Scientific Research, Jakkur, Bangalore, India / Dipak Dasgupta, Saha Institute of Nuclear Physics, Kolkata, India

Inhaltsangabe

Chromatin Structure, Dynamics and Disease.- Structural Organization of Dynamic Chromatin.- ATP-dependent Chromatin Remodelling.- Regulation of Chromatin Structure and Chromatin-Dependent Transcription by Poly(Adp-Ribose) Polymerase-1.- Histone Variant Nucleosomes.- Histone Variants and Complexes Involved in Their Exchange.- Histone Chaperones in Chromatin Dynamics.- Functions Of The Histone Chaperone Nucleolin In Diseases.- Chromatin as a Target for the DNA-Binding Anticancer Drugs.- Nonhistone Proteins, Sites for Epigenetic Marks: Link to Disease.- Reversible Acetylation Of Non Histone Proteins.- MARs and MARBPs.- Epigenetic Modifications of Chromatin: Implication in disease and therapeutics.- Aberrant Forms of Histone Acetyltransferases in Human Disease.- Chromatin Acetylation Status in the Manifestation of Neurodegenerative Diseases.- Functions of Myst Family Histone Acetyltransferases and Their Link to Disease.- Role Of Histone Phosphorylation In Chromatin Dynamics And Its Implications in Diseases.- Regulation And Function Of H3K9 Methylation.- Histone Acetylation And Methylation.- Chromatin-Associated Regulation Of Hiv-1 Transcription.- Small Molecule Modulators In Epigenetics.