Clinical Bioenergetics (eBook, ePUB)

From Pathophysiology to Clinical Translation
Redaktion: Ostojic, Sergej M.

• Format: ePub

Produktbeschreibung

Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics, as well as the safety and efficacy of emerging management strategies to address poor cellular bioenergetics. Topics discussed include the omics landscape of impaired mitochondrial bioenergetics, hormones, tissue bioenergetics and metabolism in humans. Disease-specific case studies, modes of analysis in clinical bioenergetics, and therapeutic opportunities for impaired bioenergetics, addressing both known treatment pathways and future directions for research, are discussed in-depth.

Diseases and Disorders examined include brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among others.

• Provides a thorough discussion of foundational aspects of bioenergetics and disease, modes of analysis, and treatments for impaired bioenergetics
• Discusses the role of bioenergetics and treatment pathways in brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among other diseases and disorders
• Features chapter contributions from international leaders in translational bioenergetics research and clinical practice

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 716
• Erscheinungstermin: 12. November 2020
• Englisch
• ISBN-13: 9780128227725
• Artikelnr.: 61689032

Inhaltsangabe

Part I: Foundational aspects of bioenergetics and disease 1. Tissue
specificity of energy metabolism in mitochondria 2. Impaired mitochondrial
bioenergetics and signaling pathways: an overview
Part II: Disease-specific case studies 3. Abnormal mitochondrial metabolism
in obesity and insulin resistance 4. Impaired mitochondrial energy
metabolism: etiologies and implications in neurodegenerative disease 5.
Mitochondrial dysfunction in kidney diseases 6. Mitochondrial role in NAFLD
as a chronic disease 7. Decreased bioenergetics in traumatic brain injury
8. Impaired mitochondrial bioenergetics in psychiatric disorders
Part III: Modes of analysis in clinical bioenergetics 9. Monitoring
mitochondrial oxygenation in clinical environment 10. Assessing metabolic
flexibility and mitochondrial bioenergetics 11. Assessing the real-time
metabolism and bioenergetics of single cells using fluorescence biosensors
12. Bioenergetic profiling in the skin 13. Evaluating tissue bioenergetics
by phosphorous-31 magnetic resonance spectroscopy 14. Targeting respiratory
complex Idmolecular mechanism and drug design
Part IV: Theraputic opportunities for impaired bioenergetics 15. Targeting
Alzheimer's disease neuronal mitochondria as a therapeutic approach 16.
Mitochondria replacement as an innovative treatment to tackle impaired
bioenergetics in clinical medicine 17. Mitochondrial drug delivery systems:
therapeutic application for clinical bioenergetics in neurodegenerative
disease 18. Dietary interventions for patients with obesity and impaired
bioenergetics 19. Novel nutraceuticals to tackle brain and muscle
bioenergetics 20. Therapeutic targeting of cardiolipin composition in
injury and disease using TPP-conjugated compounds 21. NEET proteins as
novel drug targets for mitochondrial dysfunction 22. Translation of
bioenergetics therapies: challenges from bench to bedside 23. New
therapeutics to modulate mitochondrial energy metabolism in
neurodegenerative disorders: the example of mitochondrial disorders 24.
Targeting impaired bioenergetics in heart failure 25. Exploring
vulnerabilities of quiescent tumor cells by targeting mitochondrial
bioenergetics 26. Modulation of the mitochondrial function with polyphenols
and other natural bioactive compounds to treat obesity 27. Antioxidants and
natural-derived products in the modulation of mitochondrial bioenergetics
and dysfunction in chronic kidney disease models 28. Transcranial and
systemic photobiomodulation for the enhancement of mitochondrial metabolism
in depression 29. Alterations in mitochondrial glucose carbon metabolism in
epilepsy and targeted metabolic treatments