With contributions from leaders in the biostatistical community, this book presents novel biostatistical methodologies in clinical trials as well as up-to-date biostatistical applications from the pharmaceutical industry. It covers emerging issues in clinical trial design and analysis, adaptive clinical trial designs, oncology clinical trials, multiple testing, and the use of biomarkers. Many real examples and case studies from drug development and cancer research illustrate the models and methods. R is also used to implement the procedures.
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