Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors (eBook, ePUB)

Redaktion: Wickstrom, Eric

• Format: ePub

Produktbeschreibung

An important new collection of clinical and preclinical reports on genetic therapy, this book describes illustrative examples of diseases in which gene-based interventions are presently plausible, and presents case studies of current research using both synthetic oligonucleotides and biological vectors. Combining the insights of over 50 contrib

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 448
• Erscheinungstermin: 13. August 2020
• Englisch
• ISBN-13: 9781000145953
• Artikelnr.: 59898549

Autorenporträt

Eric Wickstrom (Edited by)

Inhaltsangabe

A Brief History of Genetic Therapy: Gene Therapy
Antisense Technology
and Genomics
James W. Hawkins Preclinical Development of Oligonucleotide Therapeutics for Cancer: Regulatory Aspects
Chang-Ho Ahn and Joseph J. DeGeorge Commercial Scale Manufacturing of Oligonucleotides Under Good Manufacturing Practices
Jose E. Gonzalez
Richard G. Einig
Patricia Puma
Timothy P.Noonan
Paul E. Kennedy
Bruce G. Sturgeon
Bing H. Wang
and Jin-yan Tang The Regulatory Process and Gene Therapy
Suzanne L. Epstein Production of Clinical Lots of Gene Therapy Vectors Using Good Manufacturing Practice: Experience in a University Setting
Alan R. Davis and Colleen Baker Gene Therapy Clinical Trials for Adenosine Deaminase Deficiency/Severe Combined Immunodeficiency
Erlinda M. Gordon and W. French Anderson Development of an Oligodeoxynucleotide Pharmaceutical for the Treatment of Human Leukemia
Alan M. Gewirtz and Deborah Lee Sokol Clinical Trials with Anti-p53 DNA
OL(1)p53
in Patients with Acute Myelogenous Leukemia and Myelodysplastic Syndrome
Patrick L. Iversen Human Bcl-2 Antisense Therapy for Lymphomas
Finbarr E. Cotter
Andrew Webb
Paul Clarke
and David Cunningham Retroviral Gene Transfer in Autologous Bone Marrow and Stem Cell Transplantation
Rafat Abonour and Kenneth Cornetta Adenoviral Gene Transfer of the Herpes Virus Thymidine Kinase Gene for Treating Gliomas
Jane B. Alavi
Jason G. Smith
and Stephen L. Eck Distribution and Toxicity of Retroviral Vectors After Intracavitary Delivery in Mouse and Man
Patrice S. Obermiller
Anne M. Pilaro
Carlos L. Arteaga
and Jeffrey T. Holt Clinical and Immunologic Responses to Gene Transfer of an Allogeneic Major Histocompatibility Complex Antigen
Alison T. Stopeck and Evan M. Hersh Defective Tumor Suppressor Gene Replacement and Oncogene Inactivation for the Treatment of Cancer
Jack Roth The Molecular Basis of Bladder Cancer and Prospects for Gene Therapy Using Hammerhead Ribozymes
Eric J. Small
Mohammed Kashani-Sabet
David Y. Bouffard
and Kevin J. Scanlon In Situ Gene Insertion for Immunotherapy Using Vaccinia Virus Vectors
Edmund C. Lattime
Laurence C. Eisenlohr
and Michael J. Mastrangelo Antisense Oligonucleotide-Based Therapy for HIV-1 Infection from Laboratory to Clinical Trials
Sudhir Agrawal Treatment of Retinitis Induced by Cytomegalovirus Using Intravitreal Fomivirsen (Isis 2922)
Stanley T. Crooke Synthetic DNA-Based Compounds for the Prevention of Coronary Restenosis: Current Status and Future Challenges
Andrew Zalewski
Yi Shi
John D. Mannion
and Fernando Roqué Prevention of Restenosis by Gene Targeting
Michael J. Mann
Heiko E. Von der Leyen
and Victor J. Dzau