Thomas E. Ouldridge

Coarse-Grained Modelling of DNA and DNA Self-Assembly (eBook, PDF)

• Format: PDF

Produktbeschreibung

This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 176
• Erscheinungstermin: 9. Juli 2012
• Englisch
• ISBN-13: 9783642305177
• Artikelnr.: 37735777

Inhaltsangabe

A Novel DNA Model.- Methods.- Finite Size Effects.- Stuctural and Mechanical Properties of Model DNA.- Thermodynamic Properties of Model DNA.- Modelling DNA Tweezers.- Modelling a DNA Walker.