Coenzyme Q in Aging (eBook, PDF)

Redaktion: López Lluch, Guillermo

• Format: PDF

Produktbeschreibung

This book offers a comprehensive exploration of research on the essential relationship of the coenzyme Q₁₀ and the process of aging in living organisms. CoQ₁₀ is an important factor in two main aspects of cell physiology: bioenergetics and antioxidant protection. While primary deficiency of CoQ₁₀ is associated with severe and lethal disease, secondary deficiency can be associated with the progression of mitochondrial dysfunction linked to the lessening of biological activities during aging.

The book is organized in four sections. The first offers an overview of the function of CoQ_10, highlighting the two main functions of CoQ₁₀ in cells: its essential role as electron transport chain member in mitochondria, and the protection of cell membranes against oxidation as one of the main endogenous-synthesized antioxidants.

The second section covers research on Coenzyme 10. Topics include studies involving invertebrate models, mammal studies and the influence of CoQ on longevity. Also covered is research involving the role of CoQ in senescence-accelerated mice.

Section three examines the effects of reduced CoQ in human aging, as evident in mitochondrial dysfunction, metabolic syndrome, neurodegenerative disorders, immunosenescence and fertility and reproduction.

The final section, Prolongevity effectors and Coenzyme Q, explores research into slowing or stopping the aging process. Coverage includes strategies including calorie restriction, and modulation of CoQ₁₀ levels by induction of synthesis or by supplementation.

Coenzyme Q in Aging benefits a broad readership of researchers, clinicians, educators and students interested in the biochemical and physiological effects of coenzyme Q and the importance of this molecule in aging process.

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Produktdetails

• Verlag: Springer Nature Switzerland
• Seitenzahl: 369
• Erscheinungstermin: 6. August 2020
• Englisch
• ISBN-13: 9783030456429
• Artikelnr.: 59949850

Autorenporträt

Guillermo López Lluch Graduated in Biology at the University of Córdoba, Spain in July, 1992. PhD (Biology) at the University of Cordoba in July, 1997. Professor at the Pablo de Olavide, Seville, from 1998 starting as Assistant professor and obtaining a position as Lecturer/Reader in May 2003. Between June, 1999 and October, 2000 postdoctoral student granted with a Marie Curie Fellowship from the European Commission at the Department of Molecular Medicine (Rayne Institute), University College of London working on the biology of neutrophils under the supervision of Dr. Anthony W. Segal and Dr. Lodewijk V. Dekker. From October, 2018, Full Professor in the Area of Cell Biology of the Department of Physiology, Anatomy and Cell Biology of this University. Further, Associate Researcher at the Andalusian Centre for Developmental Biology (CSIC-UPO-JA) at the same University. Current research field: metabolic and antioxidant regulation during aging. The importance ofmetabolism and mitochondrial physiology is clear. Many prolongevity effectors regulate mitochondrial activity and turnover and affect endogenous antioxidant activities that seems to be coordinated with metabolism. The role of coenzyme Q and its enzymatic-dependent activities is important in this regulation and in the progression of aging and is the current focus of research. This research has produced 90 international publications, around 20 book chapters and more than 200 contributions to congresses including invited conferences.

Inhaltsangabe

Preface.- Part 1 Basics on coenzyme Q.- Introduction. The current coenzyme Q science and knowledge.- Molecular structure, biosynthesis, and distribution of coenzyme Q.- Coenzyme Q function in mitochondria.- Extramitochondrial coenzyme Q₁₀ in aging.- Regulation of the synthesis of Coenzyme Q₁₀.- Part 2 Coenzyme Q in aging studies.- Coenzyme Q and aging in C. elegans.- Coenzyme Q and aging in the fruit fly Drosophila melanogaster.- The aging process and coenzyme Q: clk-1 mouse models.- Reduced coenzyme Q₁₀ decelerates senescence and age-related hearing loss in senescence-accelerated mice by activating mitochondrial functions.- Part 3 Age-related diseases and coenzyme Q.- Coenzyme Q, mtDNA and mitochondrial dysfunction during aging.- Coenzyme Q₁₀ and metabolic syndrome.- Coenzyme Q and age-related neurodegenerative disorders: Parkinson and Alzheimer diseases.- Immunosenescence and CoQ₁₀.- Coenzyme Q₁₀ in fertility and reproduction.- Part 4 Prolongevity effectors and Coenzyme Q.- Calorie restriction, longevity and coenzyme Q.- Age dependent changes of coenzyme Q levels and its induction in experimental systems.- Effects of coenzyme Q₁₀ supplementation on elderly people.- Index.