Applications in Stereochemical Analysis of Synthetic Compounds, Natural Products, and Biomolecules Redaktion: Berova, Nina; Woody, Robert W.; Nakanishi, Koji; Polavarapu, Prasad L.
Applications in Stereochemical Analysis of Synthetic Compounds, Natural Products, and Biomolecules Redaktion: Berova, Nina; Woody, Robert W.; Nakanishi, Koji; Polavarapu, Prasad L.
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This book provides an introduction to the important methods of chiroptical spectroscopy in general, and circular dichroism (CD) in particular, which are increasingly important in all areas of chemistry, biochemistry, and structural biology. The book can be used as a text for undergraduate and graduate students and as a reference for researchers in academia and industry. Experimental methods and instrumentation are described with topics ranging from the most widely used methods (electronic and vibrational CD) to frontier areas such as nonlinear spectroscopy and photoelectron CD, as well as the…mehr
This book provides an introduction to the important methods of chiroptical spectroscopy in general, and circular dichroism (CD) in particular, which are increasingly important in all areas of chemistry, biochemistry, and structural biology. The book can be used as a text for undergraduate and graduate students and as a reference for researchers in academia and industry. Experimental methods and instrumentation are described with topics ranging from the most widely used methods (electronic and vibrational CD) to frontier areas such as nonlinear spectroscopy and photoelectron CD, as well as the theory of chiroptical methods and techniques for simulating chiroptical properties. Applications of chiroptical spectroscopy to problems in organic stereochemistry, inorganic stereochemistry, and biochemistry and structural biology are also discussed, and each chapter is written by one or more leading authorities with extensive experience in the field.
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Autorenporträt
Nina Berova is a Research Professor in the Department of Chemistry at Columbia University. She has been a coeditor of the journal Chirality (Wiley) since 1998. Prasad L. Polavarapu is currently a Professor of Chemistry at Vanderbilt University. Koji Nakanishi is one of the world's leading natural products chemists and was editor of the journal, The Chemical Record (Wiley). He retired from Columbia University in 2007, but continues to conduct research. Robert W. Woody is an Emeritus Professor at Colorado State University.
Inhaltsangabe
Comprehensive Chiroptical Spectroscopy, Volume 2 PREFACE xi CONTRIBUTORS xiii PART I A HISTORICAL OVERVIEW 1 1 THE FIRST DECADES AFTER THE DISCOVERY OF CD AND ORD BY AIME COTTON IN 1895 3 Peter Laur PART II ORGANIC STEREOCHEMISTRY 37 2 SOME INHERENTLY CHIRAL CHROMOPHORES-EMPIRICAL RULES AND QUANTUM CHEMICAL CALCULATIONS 39 Marcin Kwit, Pawel Skowronek, Jacek Gawronski, Jadwiga Frelek, Magdalena Woznica, and Aleksandra Butkiewicz 3 ELECTRONIC CD OF BENZENE AND OTHER AROMATIC CHROMOPHORES FOR DETERMINATION OF ABSOLUTE CONFIGURATION 73 Tibor Kurtan, Sandor Antus, and Gennaro Pescitelli 4 ELECTRONIC CD EXCITON CHIRALITY METHOD: PRINCIPLES AND APPLICATIONS 115 Nobuyuki Harada, Koji Nakanishi, and Nina Berova 5 CD SPECTRA OF CHIRAL EXTENDED p-ELECTRON COMPOUNDS: THEORETICAL DETERMINATION OF THE ABSOLUTE STEREOCHEMISTRY AND EXPERIMENTAL VERIFICATION 167 Nobuyuki Harada and Shunsuke Kuwahara 6 ASSIGNMENT OF THE ABSOLUTE CONFIGURATIONS OF NATURAL PRODUCTS BY MEANS OF SOLID-STATE ELECTRONIC CIRCULAR DICHROISM AND QUANTUM MECHANICAL CALCULATIONS 217 Gennaro Pescitelli, Tibor Kurtan, and Karsten Krohn 7 DYNAMIC STEREOCHEMISTRY AND CHIROPTICAL SPECTROSCOPY OF METALLO-ORGANIC COMPOUNDS 251 James W. Canary and Zhaohua Dai 8 CIRCULAR DICHROISM OF DYNAMIC SYSTEMS: SWITCHING MOLECULAR AND SUPRAMOLECULAR CHIRALITY 289 Angela Mammana, Gregory T. Carroll, and Ben L. Feringa 9 ELECTRONIC CIRCULAR DICHROISM OF SUPRAMOLECULAR SYSTEMS 317 Cheng Yang and Yoshihisa Inoue 10 THE ONLINE STEREOCHEMICAL ANALYSIS OF CHIRAL COMPOUNDS BY HPLC-ECD COUPLING IN COMBINATION WITH QUANTUM-CHEMICAL CALCULATIONS 355 Gerhard Bringmann, Daniel Gotz, and Torsten Bruhn 11 DETERMINATION OF THE STRUCTURES OF CHIRAL NATURAL PRODUCTS USING VIBRATIONAL CIRCULAR DICHROISM 387 Prasad L. Polavarapu 12 DETERMINATION OF MOLECULAR ABSOLUTE CONFIGURATION: GUIDELINES FOR SELECTING A SUITABLE CHIROPTICAL APPROACH 421 Stefano Superchi, Carlo Rosini, Giuseppe Mazzeo, and Egidio Giorgio PART III INORGANIC STEREOCHEMISTRY 449 13 APPLICATIONS OF ELECTRONIC CIRCULAR DICHROISM TO INORGANIC STEREOCHEMISTRY 451 Sumio Kaizaki PART IV BIOMOLECULES 473 14 ELECTRONIC CIRCULAR DICHROISM OF PROTEINS 475 Robert W. Woody 15 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDES 499 Claudio Toniolo, Fernando Formaggio, and Robert W. Woody 16 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDOMIMETICS 545 Claudio Toniolo and Fernando Formaggio 17 CIRCULAR DICHROISM SPECTROSCOPY OF NUCLEIC ACIDS 575 Jaroslav Kypr, Iva Kejnovska, Klara Bednarova, and Michaela Vorlickova 18 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDE NUCLEIC ACIDS AND THEIR ANALOGUES 587 Roberto Corradini, Tullia Tedeschi, Stefano Sforza, and Rosangela Marchelli 19 CIRCULAR DICHROISM OF PROTEIN-NUCLEIC ACID INTERACTIONS 615 Donald M. Gray 20 DRUG AND NATURAL PRODUCT BINDING TO NUCLEIC ACIDS ANALYZED BY ELECTRONIC CIRCULAR DICHROISM 635 George A. Ellestad 21 PROBING HSA AND AGP DRUG-BINDING SITES BY ELECTRONIC CIRCULAR DICHROISM 665 Miklos Simonyi 22 CONFORMATIONAL STUDIES OF BIOPOLYMERS, PEPTIDES, PROTEINS, AND NUCLEIC ACIDS. A ROLE FOR VIBRATIONAL CIRCULAR DICHROISM 707 Timothy A. Keiderling and Ahmed Lakhani 23 STRUCTURE AND BEHAVIOR OF BIOMOLECULES FROM RAMAN OPTICAL ACTIVITY 759 Laurence D. Barron and Lutz Hecht 24 OPTICAL ROTATION, ELECTRONIC CIRCULAR DICHROISM, AND VIBRATIONAL CIRCULAR DICHROISM OF CARBOHYDRATES AND GLYCOCONJUGATES 795 Tohru Taniguchi and Kenji Monde 25 ELECTRONIC CIRCULAR DICHROISM IN DRUG DISCOVERY 819 Carlo Bertucci and Marco Pistolozzi INDEX 843
Comprehensive Chiroptical Spectroscopy, Volume 2 PREFACE xi CONTRIBUTORS xiii PART I A HISTORICAL OVERVIEW 1 1 THE FIRST DECADES AFTER THE DISCOVERY OF CD AND ORD BY AIME COTTON IN 1895 3 Peter Laur PART II ORGANIC STEREOCHEMISTRY 37 2 SOME INHERENTLY CHIRAL CHROMOPHORES-EMPIRICAL RULES AND QUANTUM CHEMICAL CALCULATIONS 39 Marcin Kwit, Pawel Skowronek, Jacek Gawronski, Jadwiga Frelek, Magdalena Woznica, and Aleksandra Butkiewicz 3 ELECTRONIC CD OF BENZENE AND OTHER AROMATIC CHROMOPHORES FOR DETERMINATION OF ABSOLUTE CONFIGURATION 73 Tibor Kurtan, Sandor Antus, and Gennaro Pescitelli 4 ELECTRONIC CD EXCITON CHIRALITY METHOD: PRINCIPLES AND APPLICATIONS 115 Nobuyuki Harada, Koji Nakanishi, and Nina Berova 5 CD SPECTRA OF CHIRAL EXTENDED p-ELECTRON COMPOUNDS: THEORETICAL DETERMINATION OF THE ABSOLUTE STEREOCHEMISTRY AND EXPERIMENTAL VERIFICATION 167 Nobuyuki Harada and Shunsuke Kuwahara 6 ASSIGNMENT OF THE ABSOLUTE CONFIGURATIONS OF NATURAL PRODUCTS BY MEANS OF SOLID-STATE ELECTRONIC CIRCULAR DICHROISM AND QUANTUM MECHANICAL CALCULATIONS 217 Gennaro Pescitelli, Tibor Kurtan, and Karsten Krohn 7 DYNAMIC STEREOCHEMISTRY AND CHIROPTICAL SPECTROSCOPY OF METALLO-ORGANIC COMPOUNDS 251 James W. Canary and Zhaohua Dai 8 CIRCULAR DICHROISM OF DYNAMIC SYSTEMS: SWITCHING MOLECULAR AND SUPRAMOLECULAR CHIRALITY 289 Angela Mammana, Gregory T. Carroll, and Ben L. Feringa 9 ELECTRONIC CIRCULAR DICHROISM OF SUPRAMOLECULAR SYSTEMS 317 Cheng Yang and Yoshihisa Inoue 10 THE ONLINE STEREOCHEMICAL ANALYSIS OF CHIRAL COMPOUNDS BY HPLC-ECD COUPLING IN COMBINATION WITH QUANTUM-CHEMICAL CALCULATIONS 355 Gerhard Bringmann, Daniel Gotz, and Torsten Bruhn 11 DETERMINATION OF THE STRUCTURES OF CHIRAL NATURAL PRODUCTS USING VIBRATIONAL CIRCULAR DICHROISM 387 Prasad L. Polavarapu 12 DETERMINATION OF MOLECULAR ABSOLUTE CONFIGURATION: GUIDELINES FOR SELECTING A SUITABLE CHIROPTICAL APPROACH 421 Stefano Superchi, Carlo Rosini, Giuseppe Mazzeo, and Egidio Giorgio PART III INORGANIC STEREOCHEMISTRY 449 13 APPLICATIONS OF ELECTRONIC CIRCULAR DICHROISM TO INORGANIC STEREOCHEMISTRY 451 Sumio Kaizaki PART IV BIOMOLECULES 473 14 ELECTRONIC CIRCULAR DICHROISM OF PROTEINS 475 Robert W. Woody 15 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDES 499 Claudio Toniolo, Fernando Formaggio, and Robert W. Woody 16 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDOMIMETICS 545 Claudio Toniolo and Fernando Formaggio 17 CIRCULAR DICHROISM SPECTROSCOPY OF NUCLEIC ACIDS 575 Jaroslav Kypr, Iva Kejnovska, Klara Bednarova, and Michaela Vorlickova 18 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDE NUCLEIC ACIDS AND THEIR ANALOGUES 587 Roberto Corradini, Tullia Tedeschi, Stefano Sforza, and Rosangela Marchelli 19 CIRCULAR DICHROISM OF PROTEIN-NUCLEIC ACID INTERACTIONS 615 Donald M. Gray 20 DRUG AND NATURAL PRODUCT BINDING TO NUCLEIC ACIDS ANALYZED BY ELECTRONIC CIRCULAR DICHROISM 635 George A. Ellestad 21 PROBING HSA AND AGP DRUG-BINDING SITES BY ELECTRONIC CIRCULAR DICHROISM 665 Miklos Simonyi 22 CONFORMATIONAL STUDIES OF BIOPOLYMERS, PEPTIDES, PROTEINS, AND NUCLEIC ACIDS. A ROLE FOR VIBRATIONAL CIRCULAR DICHROISM 707 Timothy A. Keiderling and Ahmed Lakhani 23 STRUCTURE AND BEHAVIOR OF BIOMOLECULES FROM RAMAN OPTICAL ACTIVITY 759 Laurence D. Barron and Lutz Hecht 24 OPTICAL ROTATION, ELECTRONIC CIRCULAR DICHROISM, AND VIBRATIONAL CIRCULAR DICHROISM OF CARBOHYDRATES AND GLYCOCONJUGATES 795 Tohru Taniguchi and Kenji Monde 25 ELECTRONIC CIRCULAR DICHROISM IN DRUG DISCOVERY 819 Carlo Bertucci and Marco Pistolozzi INDEX 843
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