Victor Bloomfield

Computer Simulation and Data Analysis in Molecular Biology and Biophysics (eBook, PDF)

An Introduction Using R

• Format: PDF

Produktbeschreibung

This book provides an introduction, suitable for advanced undergraduates and beginning graduate students, to two important aspects of molecular biology and biophysics: computer simulation and data analysis. It introduces tools to enable readers to learn and use fundamental methods for constructing quantitative models of biological mechanisms, both deterministic and with some elements of randomness, including complex reaction equilibria and kinetics, population models, and regulation of metabolism and development; to understand how concepts of probability can help in explaining important features of DNA sequences; and to apply a useful set of statistical methods to analysis of experimental data from spectroscopic, genomic, and proteomic sources.

These quantitative tools are implemented using the free, open source software program R. R provides an excellent environment for general numerical and statistical computing and graphics, with capabilities similar to Matlab®. Since R is increasingly used in bioinformatics applications such as the BioConductor project, it can serve students as their basic quantitative, statistical, and graphics tool as they develop their careers

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Produktdetails

• Verlag: Springer US
• Seitenzahl: 321
• Erscheinungstermin: 5. Juni 2009
• Englisch
• ISBN-13: 9781441900838
• Artikelnr.: 37362035

Inhaltsangabe

From the contents:
Part I: The Basics of R. Calculating with R. Plotting with R. Functions and Programming. Data and Packages
Part II: Simulation of Biological Processes. Equilibrium and Steady State Calculations. Differential Equations and Reaction Kinetics. Population Models. Compartmental Models. Regulation of Metabolism. Regulation of Transcription and Development
Part III: Analyzing DNA and Protein Sequences. Probability, Stochastic Processes, and Markov Chains. DNA Sequence Analysis
Part IV: Statistical Analysis in Molecular Biology and Biophysics. Statistical Analysis of Data
Microarrays

Rezensionen

From the reviews: "This book targets biochemistry and molecular biophysics students who have prior knowledge of a few subjects, including mathematics, statistics, and modeling, and possess very basic programming skills. Examples and illustrations are ample throughout the text, and the writing style is plain and efficient. ... this book mostly appropriate for students or researchers who have prior exposure to the related subjects. Summing Up: Recommended. Upper-division undergraduates through researchers/faculty." (D. Papamichail, Choice, Vol. 47 (5), January, 2010)