Contemporary Topics in Molecular Immunology (eBook, PDF)

Volume 3
Redaktion: Ada, Gordon

• Format: PDF

Produktbeschreibung

A series of volumes devoted to molecular immunology will contain, for the most part, articles which attempt to explain immunological phenomena in terms of the behavior and properties of particular molecules. Many of the articles in this volume do this. At the same time, there are many instances-and this is particularly so in the case of immunology-where phenomena must first be described and interpreted in terms of the properties and behavior of cells. Most of us would hope that in due course a fuller understanding will be forthcoming. This volume starts off with such a contribution. Perhaps the most fascinat ing problem in immunology is how diversity is generated. There are two broad proposals: (1) that complete information exists ab initio (the germ-line theory), and (2) that there is initially a limited amount of information, and diversity is generated by somatic mutation. The issue is unresolved, but Cunningham has taken many of the data which have previously been used to support the germ-line theory and shows that the interpretations are not always clear-cut and can frequently be used to support another possibility-that new specificities may arise after stimulation of appropriate cells by antigens. And he has produced experimental evidence to support this notion. On the other hand, there can be little doubt that to a considerable degree the specificity of the immune response is determined by the selection by antigen of cells with receptors of appropriate specificity. This is essentially a surface phenomenon.

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Produktdetails

• Verlag: Springer New York
• Seitenzahl: 260
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9781468428384
• Artikelnr.: 44053671

Inhaltsangabe

The Generation of Antibody Diversity: Its Dependence on Antigenic Stimulation.- I. Introduction.- II. Explanation of the Theory.- III. Changes in the Patterns of Antibody Produced during the Course of an Immune Response.- IV. Numbers of B Cells.- V. Studies on Single Clones.- VI. Genetic Control of Antibody Production.- VII. Self-Tolerance.- VIII. Experimental Approaches.- IX. Discussion.- X. Summary.- Acknowledgments.- References.- Preparation and Properties of Lymphocyte Plasma Membrane.- I. Introduction.- II. Isolation of Plasma Membrane.- III. Properties of Plasma Membrane.- IV. Summary.- Acknowledgment.- References.- Immunogenicity In Vitro: Structural Correlation.- I. Introduction.- II. Direct Stimulation of B Cells.- III. Structure-Activity Relationships.- IV. A Special Example of Thymus-Independent Antigens - Antigen Bound to Macrophages via IgT.- V. Can Nonpolymeric Antigens Induce B-Cell Responses?.- VI. Relationship of B-Cell Differentiation to Induction.- VII. Relationship of Epitope Density to the Induction of Immunity and Tolerance.- VIII. Discussion.- IX. Abbreviations.- References.- mRNA for H and L Chains of Immunoglobulin: Specific Control of H-Chain Production.- I. Introduction.- II. L-Chain mRNA.- III. H-Chain mRNA.- IV. Nuclear Precursor of H-Chain mRNA.- V. Translational Control of H-Chain Synthesis.- VI. Specificity and Nature of H2L2 Interaction with H-Chain mRNA.- VII. Concluding Remarks.- References.- The J Chain of Polymeric Immunoglobulins.- I. Introduction.- II. Class Distribution.- III. Species Distribution.- IV. Detection of J Chain.- V. Isolation of J Chain.- VI. Physical-Chemical Properties.- VII. Chemical Composition.- VIII. Stoichiometry.- IX. Site of J-Chain Attachment.- X. The Requirement for J Chain by IgM Molecules.- XI.Cellular Origin of J Chain.- XII. The Assembly of Polymeric Immunoglobulins.- Acknowledgment.- References.- Phylogenetic Aspects of Immunoglobulin Variable Region Diversity.- I. Introduction.- II. Variable Region Subgroups.- Acknowledgments.- References.- Separation Methods for Lymphocyte Populations.- I. Introduction.- II. Preliminary Steps: Preparation of Clean Cell Suspensions.- III. Separation Based on the Physical Parameters of Cells.- IV. Adherence Separation of Lymphocytes and Phagocytes.- V. Separation Based on Specific Cell Surface Receptors and Antigens.- VI. Electronic Cell Sorting.- References.- Radioelectrocomplexing: A General Radioimmunoassay Procedure for the Detection of Primary Binding of Antigen by Antibody.- I. Introduction.- II. Materials and Methods.- III. Quantitative Studies.- IV. Applications of Radioelectrocomplexing.- V. Summary and Conclusions.- Acknowledgments.- References.