David Pfister

Continuous Biopharmaceutical Processes (eBook, PDF)

Chromatography, Bioconjugation, and Protein Stability

• Format: PDF

Produktbeschreibung

This innovative reference provides a coherent and critical view on the potential benefits of a transition from batch to continuous processes in the biopharmaceutical industry, with the main focus on chromatography. It also covers the key topics of protein stability and protein conjugation, addressing the chemical reaction and purification aspects together with their integration. This book offers a fine balance between theoretical modelling and illustrative case studies, between fundamental concepts and applied examples from the academic and industrial literature. Scientists interested in the design of biopharmaceutical processes will find useful practical methodologies, in particular for single-column and multi-column chromatographic processes.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: Cambridge University Press
• Erscheinungstermin: 11. Oktober 2018
• Englisch
• ISBN-13: 9781108352185
• Artikelnr.: 56531000

Autorenporträt

David Pfister is project manager at Ypso Facto (Nancy, France), where he is developing the software ChromWorks, which has been used to perform the large majority of the simulations of chromatographic processes shown in this book. He was a doctorate student of Professor Morbidelli at Eidgenössische Technische Hochschule Zürich (ETH Zurich) and graduated in 2015. His Ph.D. thesis focused on protein conjugation, and his research also dealt with the fundamental understanding of protein chromatography. Before joining ETH Zurich, he obtained a master degree in chemical engineering from École Nationale Supérieure des Industries Chimiques (Nancy, France).

Inhaltsangabe

Preface
1. Introduction to biopharmaceutical processes
2. Fundamentals of protein chromatography
3. Counter-current separation processes
4. Counter-current chromatography for the capture step
5. Counter-current chromatography for the polishing steps
6. Protein conjugation
7. Protein aggregation in biopharmaceutical processes
8. Conclusion
References
Notation
Index.