Coordinating Organismal Physiology Through the Unfolded Protein Response (eBook, PDF)

Redaktion: Wiseman, R. Luke; Haynes, Cole M.

• Format: PDF

Produktbeschreibung

This volume reviews the current research focused on the functional importance of unfolded protein response (UPR) signaling in the context of health and disease. The chapters present cutting-edge work describing the diverse functions of UPR signaling critical for regulating cellular and organismal physiology under physiologic and pathologic conditions. Written by internationally respected scientists, this volume is designed to provide a broad view of the diverse functional importance of UPR, and as such appeals to clinicians and academic researchers alike.

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Produktdetails

• Verlag: Springer International Publishing
• Seitenzahl: 213
• Erscheinungstermin: 18. April 2018
• Englisch
• ISBN-13: 9783319785301
• Artikelnr.: 52444207

Autorenporträt

R. Luke Wiseman Associate Professor Department of Molecular Medicine The Scripps Research Institute MEM 220 La Jolla, CA 92037, USA Phone: [phone] Email: [e-mail] Cole M. Haynes Associate Professor University of Massachusetts Medical School Worcester, MA 01605, USA Email:[e-mail]

Inhaltsangabe

Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response.- Cell Non-Autonomous UPR^ER Signaling.- The unfolded protein response in the immune cell development: Putting the caretaker in the driving seat.- Mitochondria associated membranes and ER stress.- Coordinating Organismal Metabolism during Protein Misfolding in the ER Through the Unfolded Protein Response.- ER stress and neurodegenerative disease: a cause or effect relationship?- Driving cancer tumorigenesis and metastasis through UPR signaling.- ER Protein Quality Control and the Unfolded Protein Response in the Heart.