Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C-H Bonds (eBook, PDF)

Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C-H Bonds (eBook, PDF)

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This thesis reports the latest developments in the direct amination of various C-H bonds using an H-Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.The material outlined in this book shows how McDonald achieved C-H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.McDonald's findings are of relevance to ...

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