Cyclic Nucleotide Signaling (eBook, ePUB)

Redaktion: Cheng, Xiaodong

• Format: ePub

Produktbeschreibung

Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling.

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Produktdetails

• Verlag: Taylor & Francis
• Erscheinungstermin: 7. Mai 2015
• Englisch
• ISBN-13: 9781040212790
• Artikelnr.: 72303519

Autorenporträt

Cheng, Xiaodong

Inhaltsangabe

Compartmentalization of cyclic nucleotide signaling. Analysis of
EPAC-mediated cAMP functions in cell communication. Cyclic nucleotide
analogs as pharmacological tools for studying signaling pathways. Discovery
of small molecule EPAC specific modulators. Adenylyl cyclase and A
kinase-anchoring proteins in cardiovascular physiology and pathology.
Cyclic nucleotide recognition and selectivity. Real-time intracellular
imaging of cGMP. Dissecting cyclic nucleotide signalosomes by chemical
proteomics. Cyclic nucleotide analogs as chemical tools for interaction
analyses. cAMP signaling in pancreatic ß cells. Quantitative high
throughput cAMP assay for G-protein coupled receptors. Quantitative
proteomics analysis of the cAMP signaling pathway. Network analysis of
cyclic nucleotide signaling. Evolution and functional diversity of cyclic
nucleotide binding domains. X-ray crystallographic analysis of cyclic
nucleotide activated protein kinases. Dissect physiological functions of
PKA isoforms using genetically modified mouse models. Assessing cyclic
nucleotide binding domain allostery by NMR analysis. Fluorescence resonance
energy transfer (FRET) imaging of cyclic nucleotide in live cells.
Structural and functional analyses of exchange protein directly activated
by cAMP. Structural analysis of PKA: strategies for therapeutic
intervention. Monitoring cyclic nucleotide signaling using genetically
encoded fluorescent reporters.