This book provides the first single source of comprehensive information on the human cytochrome P450 2D6 gene-or CYP2D6-that serves as an important reference for medical, biomedical, pharmaceutical, and nursing researchers, practitioners, and students. It reviews the current knowledge of CYP2D6 as well as the maturing body of evidence indicating its significance to clinical and pharmacological research and practice. It examines the genetic, epigenetic, physiological, pathological, and structural factors of CYP2D6 that govern the highly variable metabolism of a number of drugs in clinical use and indicates paths for future research.
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