Walter Gottlieb Land

Damage-Associated Molecular Patterns in Human Diseases (eBook, PDF)

Volume 3: Antigen-Related Disorders

• Format: PDF

Produktbeschreibung

This book is a continuation of the topic of "DAMPs in Human Diseases", the basics of which were described in a first volume, and details of their role in polytrauma, solid organ injuries, atherosclerosis, and cerebrocardiovascular diseases in a second volume by the same author. The third volume presents our current understanding of the impact of DAMP-driven innate/adaptive immune responses on the etiopathogenesis of antigen-related disorders, focusing on infectious and autoimmune diseases (highlighting respiratory virus diseases such as COVID-19, bacterial sepsis, and malaria) and autoimmune diseases (emphasizing systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, type 1 diabetes), and briefly discussing allograft and tumor rejection. The detailed description and illustration of DAMP-triggered inflammatory pathways in the various chapters explain, for example, why it is the dysregulated emission of DAMPs - and not the virus or the bacterium per se- that is responsible for admitting COVID-19 or sepsis patients to the ICU for intensive care treatment. Also, the chapters on autoimmune diseases explain why, mechanistically, environmental factors make up a significant part of the risk in disease initiation and propagation.

Our growing understanding of such deleterious pathogenetic functions of activating DAMPs and suppressing DAMPs (SAMPs) is used as a point of departure to explore how these molecules can be used as valuable diagnostic and prognostic biomarkers as well as future therapeutic targets and therapeutics.

The book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from modern inflammation and immunity research into clinical practice. In this sense, the book reflects an approach to translational medicine. The readership will include all practitioners and clinicians, in particular, ICU clinicians, infectiologists, microbiologists, virologists,hematologists, rheumatologists, diabetologists, neurologists, transplantologists, oncologists, and pharmacists.

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Produktdetails

• Verlag: Springer Nature Switzerland
• Seitenzahl: 677
• Erscheinungstermin: 10. März 2023
• Englisch
• ISBN-13: 9783031217760
• Artikelnr.: 67597273

Autorenporträt

Walter G. Land is Professor Emeritus of the LMU University in Munich, Germany. After earning his MD, he spent four years specializing in Experimental Surgery, Immunology, and Organ Transplantation at the Institute for Surgical Research, LMU University, Munich. In 1979 he performed the first pancreas transplant in Germany at Klinikum Großhadern, where he subsequently spent almost 30 years as Head of the Transplantation Center. He also held a position as C3 Professor for Surgery and Transplantation Surgery in Munich for almost 20 years, until 2004. Currently, he is Emeritus Professor at LMU University Munich and Ancien Professeur Conventionné at the University of Strasbourg, France.

Professor Land is an Elected Member of the German National Academy of Sciences Leopoldina and the European Academy of Sciences and Arts; also, he is an Honorary Member of the American Society of Transplant Surgeons and the European Academy of Tumor Immunology.

Professor Land has been a co-founder of many European and German Societies, including the European Society for Organ Transplantation (ESOT), European College of Organ Transplantation, the German Transplantation Society, the German Academy of Transplantation Medicine, and the Society of Innate Immunity.

Professor Land has chaired the European Society for Organ Transplantation, the Society of Transplantation and Innate Immunity, and the Society of Innate Immunity. He is the author or editor of many articles and books, was awarded the Erich Lexer Prize by the German Surgical Society in 1991, the Order of Merit of the Federal Republic of Germany in 1996, the Bavarian State Medal for Social Merit in 1997, the Millennium Medal of the Transplantation Society in 2000, and the Maharshi Sushruta Prize for Transplantation Biology in India in 2005.

Inhaltsangabe

Part I. The Three Major Paradigms in Modern Immunology.- Prologue: The Term "Immunity" over the Course of Time.- The Three Major Paradigms in Immunology.- Epilogue: What Major Paradigm in Immunology Comes Next?.- Part II. The Innate Immune System: an Organ of Perception Determined to Maintain Homeostasis.- Prologue: The Guardians of Homeostasis.- Innate Immune Recognition Molecules.- Epilogue: The Innate Immune System: a Global Player in Health and Disease.- Part III. The Whole Family of Mammalian Innate Immune Cells.- Prologue: The Whole Body as an Immune System?.- Mobile Innate Immune Cells.- Sessile Innate Immune Cells.- Epilogue: The Whole Body as an Immune Defence System.- Part IV. The World of DAMPs. Prologue: About DAMPs, PAMPs and MAMPs.- Endogenous DAMPs, Category I: Constitutively Expressed Native Molecules (Cat. I DAMPs).- Endogenous DAMPs, Category II: Constitutively Expressed, Injury-Modified Molecules (Cat. II DAMPs).- Endogenous DAMPs, Category III: Inducible DAMPs (Cat. III DAMPs).- Exogenous DAMPs, Category IV (Cat. IV DAMPs).- Epilogue: The Well-Dosed Work of DAMPs in their Commission to Restore and Maintain Homeostasis.- Part V. Cellular Stress Responses and Regulated Cell Death.- Prologue: Innate Immune Tools to Defend against Stressful Injury: Success and Failure.- Cell-Autonomous (Cell-Intrinsic) Stress Responses.- Regulated Cell Death.- Epilogue: The Horror of an Injury-Induced Avalanche of DAMPs.- Part VI. Innate Immune Effector Responses.- Prologue: The Various Facets of Innate Immune Effector Responses.- Cellular Inflammatory Responses.- Humoral Innate Immune Effector Responses.- Regulation of Innate Inflammatory Responses.- Epilogue to Part VI.- Part VII. Function of Innate Lymphoid Cells and Unconventional T Cells with Partial Innate Function.- Prologue: The "Ready-to-Go" Lymphocytes of the Immune System.- Activating and Function of Innate Lymphoid Cells.- Activating and Function of Unconventional T Cells.- Epilogue: Killer Lymphocytes as Tools for Future Immunotherapeutic Approaches.- Part VIII. DAMPs Promoting Adaptive Immunity and Tissue Repair.- Prologue: The "Long Arm" of DAMPs in Shaping Adaptive Immune Responses and Tissue Repairing Processes.- Antigen Uptake, Processing and Presentation by Dendritic Cells.- Antigen in the Presence of DAMPs Induces Immunostimulatory Dendritic Cells to Promote "Destructive" Acquired Immune Responses.- Antigen in the Absence of DAMPs Promotes Immunotolerance: the Role of Dendritic Cells and Regulatory T Cells.- An Impressive Example of Peripheral Tolerance against Nonself: Tolerance to Commensal Bacterial and Dietary Protein Antigens.- Immunometabolism of Dendritic Cells and T Cells.- Role of DAMPs in Tissue Regeneration and Repair.- Epilogue: DAMPs as Key Players in the Pathogenesis of Many Human Diseases.