Development of In-Tether Carbon Chiral Center-Induced Helical Peptide (eBook, PDF)
Kuan Hu
eBook, PDF

Development of In-Tether Carbon Chiral Center-Induced Helical Peptide (eBook, PDF)

Methodology and Applications

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This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein-protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely "chiral center induced peptide helicity (CIH)". The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it report...

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