Kuan Hu

Development of In-Tether Carbon Chiral Center-Induced Helical Peptide (eBook, PDF)

Methodology and Applications

• Format: PDF

Produktbeschreibung

This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein-protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely "chiral center induced peptide helicity (CIH)". The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers' understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs.

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Produktdetails

• Verlag: Springer Nature Singapore
• Seitenzahl: 102
• Erscheinungstermin: 26. Januar 2021
• Englisch
• ISBN-13: 9789813366138
• Artikelnr.: 61089338

Inhaltsangabe

Introduction.- Method to construct in-tether chiral center constrained helical peptide.- Application in disrupting p53/MDM2 protein-protein interactions.- Fabrication of nanomaterials with in-tether chiral center constrained helical peptide.